Pubergen Aqua 5000 Injection 1 ml is used in the treatment of female infertility, male hypogonadism and cryptorchidism. Female infertility is when a woman is unable to get pregnant within a year of trying. Male hypogonadism is a condition in which the body does not produce enough hormones responsible for masculine growth in men. Cryptorchidism is a condition in which testes don’t descend into the scrotum (bag of skin present below the penis).

Pubergen Aqua 5000 Injection 1 ml contains ‘human chorionic gonadotrophin’ used in the treatment of female infertility and male hypogonadism. It stimulates the production of sex hormones such as testosterone in men and progesterone in women. It can stimulate ovulation (egg production) in women and improve sperm production in men.

Pubergen Aqua 5000 Injection 1 ml is usually administered by a healthcare professional. The common side effects of Pubergen Aqua 5000 Injection 1 ml are pain at the injection site, headache, irritability, restlessness, depression, fatigue, oedema (swelling), early puberty and gynecomastia (swelling of breast tissue in men).

Do not take Pubergen Aqua 5000 Injection 1 ml if you are allergic to ‘human chorionic gonadotrophin’ or any other ingredients present in it. It should not be used in patients with conditions such as early puberty, prostatic cancer or other androgen-dependent cancers, unexplained vaginal bleeding, uncontrolled thyroid or adrenal gland dysfunction and ovarian cysts. It is not recommended for use in pregnant women and should be used with caution in breastfeeding mothers. 

Pubergen Aqua 5000 Injection 1 ml contains ‘human chorionic gonadotropin’, which belongs to the class of ‘sex hormones’. It is used in treating female infertility in whom the cause of ovulation problems is a secondary ovarian failure (normal ovaries that don’t function properly). It can also treat male hypogonadism in which the testes are normal but don’t function properly. It can treat cryptorchidism in boys from age 4 to 9 if there is no structural deformity. However, the descending of testes into the scrotum is usually temporary when Pubergen Aqua 5000 Injection 1 ml is used.

• Injection site pain
• Headache
• Irritability
• Restlessness
• Depression
• Fatigue
• Oedema (swelling)
• Early puberty
• Gynecomastia (swelling of breast tissue in men)

Pubergen Aqua 5000 Injection 1 ml may cause multiple pregnancies (pregnant with more than one child at the same time). So, discuss with your doctor the possible risks of this medicine. It can increase the risk of blood clots. An anaphylactic reaction such as shortness of breath, hives, loss of consciousness, low pulse and shock have been reported with HCG products derived from urine. In some cases, worsening of preexisting ovarian cysts or sudden ovary enlargement can be seen. So, regular monitoring is required. Early puberty may be seen in children. In such cases, discontinue therapy immediately and consult a doctor.

Drug-Drug Interaction: Inform your doctor about the medicines you take, including prescription and non-prescription drugs before starting Pubergen Aqua 5000 Injection 1 ml.

Drug-Food Interaction: No interactions were found.

Drug-Disease Interaction: Pubergen Aqua 5000 Injection 1 ml is contraindicated in conditions such as early puberty and androgen-dependent cancers, unexplained vaginal bleeding, uncontrolled thyroid or adrenal gland dysfunction, and ovarian cysts. It should be used with caution in patients with heart or kidney disease, epilepsy (fits), migraine (persistent headache), or asthma (a lung problem).

• Consume a healthy diet that is rich in fibre, proteins and low in carbohydrates, fats.

• Avoid processed or high-sugar foods.

• Stay active and shed excess weight if you are overweight or obese. Do not perform intense exercises as it may negatively impact your reproductive health. Increase the intensity of exercise gradually.

• Being underweight may also affect fertility. So, prepare a diet chart that can help you to gain weight healthily.

• Avoid stress as it may affect your fertility. Try relaxation techniques and receive support and counselling if necessary.

• Limit alcohol and caffeine intake.

• Quit smoking.

• To be sure HCG is helping your condition, your doctor will need to check you on a regular basis. Do not miss any scheduled appointments.

• Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any symptoms of OHSS like severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting or if you are urinating less than normal.

Female infertility: When a woman is not able to become pregnant within a year of trying. If a woman gets pregnant but experiences miscarriages or stillbirths, it is also included in infertility.

Male hypogonadism: It is a condition in which hormones such as testosterone responsible for masculine growth in men are not produced enough in the body. It may cause decreased sexual desire, erectile dysfunction and low sperm production.

Cryptorchidism: It is a condition in which testis fails to descend into the scrotum of boys. It is commonly seen in boys with premature birth and can be easily identified in newborns.