Prulooz-1 Tab is used to treat chronic idiopathic constipation. Chronic idiopathic constipation is a functional bowel disorder characterised by difficult or incomplete and/or infrequent passage of stools that lasts for 3months or longer and is not caused by any disease or medication. 
 
Prulooz-1 Tab contains ‘prucalopride’, which acts on the muscle walls of the gut, and increases bowel motility. Thereby, helps restore the normal functioning of the bowel and treats constipation. Prulooz-1 Tab helps treat chronic constipation in adults in whom laxatives do not work well. 
 
You are advised to take Prulooz-1 Tab for as long as your doctor has prescribed it to you. In some cases, you may experience certain common side effects, such as headache, diarrhoea, nausea, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Avoid taking Prulooz-1 Tab if you are pregnant or breastfeeding. Prulooz-1 Tab is not recommended for children below 18 years as safety and effectiveness have not been established. Prulooz-1 Tab may cause dizziness and tiredness, so drive only if you are alert. Keep your doctor informed about your health condition and the medicines you are taking to rule out any unpleasant side effects or interactions.

Prulooz-1 Tab belongs to the group of medicines called gastrointestinal prokinetics used to treat chronic idiopathic constipation. Prulooz-1 Tab acts on the muscle walls of the gut and increases bowel motility. Thus, helps restore the normal functioning of the bowel and treats constipation. Prulooz-1 Tab helps treat chronic constipation in adults in whom laxatives do not work well. 

• Abdominal pain/cramps
• Headache
• Diarrhoea
• Vomiting
• Tiredness
• Nausea

Do not take Prulooz-1 Tab if you are allergic to any of its components, if you are on renal dialysis, have perforation/obstruction of the gut wall, inflammation of the intestinal tract, Crohn’s disease, toxic megacolon/megarectum or ulcerative colitis. Inform your doctor if you have AIDS, hormonal problems, neurological disease, suicidal tendency, mood disorder, cancer, heart, kidney or liver problems. Avoid taking Prulooz-1 Tab if you are pregnant or breastfeeding. Prulooz-1 Tab is not recommended for children below 18 years as safety and effectiveness have not been established. Prulooz-1 Tab may cause dizziness and tiredness, so drive only if you are alert.

Drug-Drug Interactions: Prulooz-1 Tab may interact with an antihistamine (diphenhydramine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have renal dialysis, perforation/obstruction of the gut wall, inflammation of the intestinal tract, Crohn’s disease, toxic megacolon/megarectum, ulcerative colitis, mood disorders, or suicidal tendency.

• DIPHENHYDRAMINE

• Try maintaining a balanced diet that includes fresh fruits and vegetables.

• Stay hydrated, drink enough water and fluids.

• Exercise regularly, and stay fit.

• Get enough sleep.

• Try making time to empty your bowels whenever the body tells you to.

• Eat food rich in fibre such as whole-wheat bread, oatmeal, flaxseed, nuts, beans, lentils, fruits (berries, apples, oranges, bananas, pears, figs) and vegetables (broccoli, spinach, sweet potatoes, avocados).

Chronic idiopathic constipation: Chronic idiopathic constipation is a functional bowel disorder characterised by difficult or incomplete and/or infrequent passage of stools that lasts for 3months or longer and is not caused by any disease or medication. Symptoms include bloating, abdominal pain, and feeling as if the bowel movement is incomplete. Constipation occurs when the normal muscle contractions in the large intestine slow down, which causes the incomplete elimination of the bowel from the body. Constipation could be associated with a sudden change of diet, a diet with less fibre, not drinking enough liquids, lack of exercise, loss of tone of the bowel muscles in older people, or having to stay in bed for a longer duration.