Presafe 250mg Injection is a female hormone that treats various medical conditions, including early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods) to judge oestrogen priming.

Presafe 250mg Injection contains progesterone; it works by increasing levels of the progesterone hormone in your body.

Presafe 250mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, you may experience injection site reactions, rash or any other allergy, changes in the breast, darkening of facial skin, scalp hair loss, coarsening of hair in abnormal regions, nausea, fever, and sleep disturbances. Most of these side effects of Presafe 250mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Presafe 250mg Injection if you are allergic to any content of this medicine. You should disclose to your doctor if you have a blood clot caused by swollen veins (thrombophlebitis), a blocked blood vessel (thromboembolic disorder), a stroke, a diagnosed or suspected vaginal infection, the use of any other vaginal application products, or any ongoing medical conditions such as cancer of the breasts or genital organs. Let your doctor also know if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine.

Presafe 250mg Injection belongs to the class of medicines known as hormones. It is used to maintain early pregnancy in cases of documented history of repeated miscarriages due to luteal phase defect and in selected cases as an adjunct to successful infertility treatment with techniques such as in vitro fertilisation (IVF) or gamete intra-fallopian transfer (GIFT) to facilitate uterine implantation of the fertilised ovum. In cases of secondary amenorrhoea (paused or missed periods), it can also be used as a progesterone withdrawal test to assess oestrogen priming. Furthermore, it can treat threatening abortions and dysfunctional uterine haemorrhages.

• Injection site reactions

• Rash or any other allergy

• Changes in breast

• Darkening of facial skin

• Scalp hair loss

• Coarsening of hair in abnormal regions

• Nausea

• Fever

• Sleep disturbances

Please tell your doctor if you are allergic to Presafe 250mg Injection or any other medicines. Inform your doctor if you are diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, a blocked blood vessel, vaginal infections, and missed abortion. Let your doctor know your complete medical history and all your ongoing medication before receiving the Presafe 250mg Injection to rule out any side effects.

• Do regular exercise and physical activity to minimize hot flushes and improve sleep. Aerobics, yoga, and activities like tai chi may help relax the body and mind.

• Try to wear loose clothes before going to bed and sleep in a cool, well-ventilated room. Doing this can prevent symptoms of hot flushes and night sweats. Sleep at least for 8 hours.

• Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.

• Try to be stress-free to improve your mood swings due to hormonal fluctuations.

• Quit smoking as it will help to reduce hot flushes and your risk of developing chronic conditions like heart disease, stroke, and cancer.