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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Premeal 0.5mg Tablet is used to treat type 2 diabetes. It contains Repaglinide which works by increasing the amount of insulin released by the pancreas. In some cases, this medicine may cause side effects such as headache, stomach pain, common cold, diarrhoea, joint pain and back pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Composition :

REPAGLINIDE-0.5MG

Manufacturer/Marketer :

Elsker Life Science

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Premeal 0.5mg Tablet

Premeal 0.5mg Tablet belongs to the category of medicines called 'anti-diabetic primarily used for the management and treatment of type 2 diabetes, especially in persons whose sugar levels are too high and cannot be only controlled by dieting and exercising. Type 2 diabetes is a condition that occurs when there is either less insulin or available insulin is not properly utilized by our body cells for lowering raised blood glucose. It is the most common type of diabetes, accounting for around 90% of total diabetes cases found commonly in middle-aged people. So it is also called adult-onset diabetes or non-insulin-dependent diabetes mellitus (NIDDM).

Premeal 0.5mg Tablet contains 'Repaglinide', a meglitinide that works by increasing the amount of insulin released by the pancreas. It starts acting so quickly on controlling blood sugar levels immediately after a meal. Premeal 0.5mg Tablet may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Your doctor will decide what dose should be taken for better advice, and it can change timely depending upon your condition. In some cases, you may experience headache, stomach pain, a sign of a common cold, diarrhoea, joint pain and back pain. Most of these side effects of Premeal 0.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

You should not take Premeal 0.5mg Tablet if you have type 1 diabetes mellitus, renal impairment, metabolic acidosis, diabetic ketoacidosis (excess acids in your blood), or severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant, or are breastfeeding. Premeal 0.5mg Tablet should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Premeal 0.5mg Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy).

Uses of Premeal 0.5mg Tablet

Treatment of Type 2 Diabetes Mellitus.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Premeal 0.5mg Tablet belongs to the group of medicines called “anti-diabetic” indicated in the treatment of type 2 diabetes or non-insulin-dependent diabetes (NIDDM). This medicine is primarily prescribed to persons whose blood sugar levels are high and is even not controlled by diet and exercise alone. Premeal 0.5mg Tablet consists of Repaglinide belongs to a class of meglitinide that works by increasing the amount of insulin released by the pancreas. It starts acting so quickly on controlling blood sugar levels immediately after a meal. Premeal 0.5mg Tablet may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

How Premeal 0.5mg Tablet Works

Premeal 0.5mg Tablet contains 'Repaglinide', a meglitinide that works by increasing the amount of insulin released by the pancreas. It starts acting so quickly on controlling blood sugar levels immediately after a meal. Premeal 0.5mg Tablet may be advised with or without other medications along with diet and exercise to control blood sugar levels.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Premeal 0.5mg Tablet

  • Headache
  • Stomach pain
  • Sign of a common cold
  • Diarrhoea
  • Joint pain
  • Back pain

What if I have taken an overdose of Premeal 0.5mg Tablet

Take Premeal 0.5mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypoglycaemia (extreme weakness, sweating, blurred vision, trouble speaking, stomach pain, tremors, confusion, and seizure). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Premeal 0.5mg Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (in this condition, there is too much lactic acid accumulated in the blood). Inform your doctor if you take other antidiabetic drugs to adjust the dosage of Premeal 0.5mg Tablet accordingly. Do not abruptly stop taking Premeal 0.5mg Tablet midway if the doctor did not advise you. Premeal 0.5mg Tablet may cause hypoglycaemia (low blood sugar), hence it is advised to make healthy food with enough calories and avoid heavy exercises.  Premeal 0.5mg Tablet is not recommended for use during pregnancy and breastfeeding. Your doctor may advise alternate medications to control your diabetic condition in such cases. Premeal 0.5mg Tablet is not recommended for people younger than 18 years or over 75 years of age.  Before you start taking Premeal 0.5mg Tablet , tell your doctor if you have serious heart disease or if you have had a stroke, low blood pressure (hypotension), and severe liver or kidney disease. Avoid alcohol intake while using Premeal 0.5mg Tablet since it may increase the risk of lactic acidosis. 

Drug-Drug Interactions

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RepaglinideGemfibrozil
Critical
RepaglinideGatifloxacin
Critical

Drug-Drug Interactions

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RepaglinideGemfibrozil
Critical
How does the drug interact with Premeal 0.5mg Tablet:
When Premeal 0.5mg Tablet is taken with Gemfibrozil, the level of Premeal 0.5mg Tablet in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Premeal 0.5mg Tablet with Gemfibrozil can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RepaglinideGatifloxacin
Critical
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Premeal 0.5mg Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Premeal 0.5mg Tablet can be taken with Gatifloxacin if prescribed by the doctor. However, consult the doctor if you experience unusual symptoms. Do not stop using any medications without first talking to your doctor.
RepaglinideEluxadoline
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Premeal 0.5mg Tablet with eluxadoline may increase the blood levels Premeal 0.5mg Tablet.

How to manage the interaction:
Although taking Premeal 0.5mg Tablet together with Eluxadoline can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience any unusual symptoms Do not discontinue any medicine without consulting a doctor.
RepaglinideNorfloxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Norfloxacin with Premeal 0.5mg Tablet may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Norfloxacin can be taken with Premeal 0.5mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without talking to a doctor.
RepaglinideCiprofloxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Taking Premeal 0.5mg Tablet with ciprofloxacin can effect blood sugar levels, both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).

How to manage the interaction:
Although taking ciprofloxacin and Premeal 0.5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, tell your doctor if you experience hypoglycemia, hyperglycemia, or a decline in blood glucose control. Hypoglycemia can cause headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, sweat, palpitations, and a rapid heartbeat. Increased hunger, thirst, and urine are all possible signs of hyperglycemia. Consult your doctor if you experience any of the above symptoms.
RepaglinideCinoxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Taking Premeal 0.5mg Tablet with cinoxacin can affect blood glucose levels. Both high blood glucose (hyperglycemia) and, to a lesser extent, low blood glucose (hypoglycemia).

How to manage the interaction:
Although taking Premeal 0.5mg Tablet together with Cinoxacin can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms of hypoglycemia, such as headache, dizziness, drowsiness, anxiety, weakness, tremors, nausea, hunger, sweating, and fast heartbeat. Do not discontinue any medicine without consulting a doctor.
RepaglinideOfloxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Co-administration of Ofloxacin and Premeal 0.5mg Tablet can sometimes have an effect on blood glucose levels.

How to manage the interaction:
Although combining Ofloxacin and Premeal 0.5mg Tablet can possibly lead to an interaction, they can be taken on doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), notify your doctor. Keep an eye on your blood glucose levels. Do not discontinue any medications without first consulting a doctor.
RepaglinideLevofloxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Premeal 0.5mg Tablet with levofloxacin can affect blood glucose levels. Both high blood glucose (hyperglycemia) and, to a lesser extent, low blood glucose (hypoglycemia).

How to manage the interaction:
Although concomitant administration of levofloxacin with Premeal 0.5mg Tablet can result in an interaction, they can be taken if a doctor has advised it. Inform doctor if you experience hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose), or if you have a lack of blood glucose control. Headache, dizziness, sleepiness, anxiety, confusion, a shaking sensation, nausea, hunger, weakness, sweat, palpitation, and fast pulse are all symptoms of hypoglycemia. Hyperglycemia symptoms may include increased thirst, increased appetite, and increased urine. Do not stop using any medications without talking to a doctor.
RepaglinideEnoxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Premeal 0.5mg Tablet with enoxacin can affect blood glucose levels. Both high blood glucose (hyperglycemia) and, to a lesser extent, low blood glucose (hypoglycemia).

How to manage the interaction:
Although taking Premeal 0.5mg Tablet together with Enoxacin can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms of hypoglycemia(low blood sugar), such as headache, dizziness, drowsiness, anxiety, weakness, tremors, nausea, hunger, sweating, and palpitation and symptoms of hyperglycemia(high blood sugar) such as increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
RepaglinideGemifloxacin
Severe
How does the drug interact with Premeal 0.5mg Tablet:
Coadministration of Premeal 0.5mg Tablet with gemifloxacin can affect blood glucose levels. Both high blood glucose (hyperglycemia) and, to a lesser extent, low blood glucose (hypoglycemia).

How to manage the interaction:
Although taking Premeal 0.5mg Tablet together with Gemifloxacin can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms of hypoglycemia or hyperglycemia, such as headache, dizziness, drowsiness, anxiety, weakness, tremors, nausea, hunger, sweating, and palpitation, increased thrust, increased hunger, and increased urination. Do not discontinue any medicine without consulting a doctor.

Drug-Food Interactions

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REPAGLINIDE-0.5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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REPAGLINIDE-0.5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Premeal 0.5mg Tablet and grapefruit or grapefruit juice together can increase the blood levels and effects of Premeal 0.5mg Tablet. Avoid the consumption of Grapefruit or grapefruit juice.

Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
  • Eat at regular intervals. Do not take the long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest in at least 150 min of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates containing whole-grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. You may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil for frying.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Premeal 0.5mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Premeal 0.5mg Tablet is pregnancy category C drug. As the data around the use of Premeal 0.5mg Tablet in pregnant women is limited, the use of Premeal 0.5mg Tablet in pregnancy is restricted. It is highly recommended to consult your doctor before taking this drug in case you are pregnant.

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Breast Feeding

Caution

It is unknown whether Premeal 0.5mg Tablet is excreted in human milk. Please consult a doctor before using Premeal 0.5mg Tablet while breastfeeding.

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Driving

Caution

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you also experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar.

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Liver

Caution

Premeal 0.5mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor. However, Premeal 0.5mg Tablet is not recommended for severe liver disease.

bannner image

Kidney

Caution

Premeal 0.5mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor. However, Premeal 0.5mg Tablet is not recommended for severe kidney disease.

bannner image

Children

Unsafe

The safety and efficacy of Premeal 0.5mg Tablet in children have not been established. Premeal 0.5mg Tablet is not recommended in children.

FAQs

Premeal 0.5mg Tablet is used for the management and treatment of type 2 diabetes, especially in persons whose sugar levels are too high and cannot be only controlled by dieting and exercising.

Premeal 0.5mg Tablet contains Repaglinide that works by increases the amount of insulin released by the pancreas which prevents blood glucose from rising very high after meals.

Hypoglycemia refers to low blood sugar levels, and it is one of the side effects of Premeal 0.5mg Tablet . Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with this medicine. It is important to monitor blood sugar levels regularly.

Type-2 diabetes generally does not affect healthy children and teens, but it may affect children who are obese, which is also known as Childhood Obesity.

If a person is getting unusually thrust or passing urine frequently more than normal while taking Premeal 0.5mg Tablet , they should tell it to their doctor as it may be a sign that there is too much sugar in their blood and treatment needs to be adjusted. It may also because of dehydration as Premeal 0.5mg Tablet can lead to loss of fluids. Increase intake of fluids, if even then you feel thirsty, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

unit no. 218, second floor, amba tower, d. c. chowk, sector 9, rohini, north west, delhi
Other Info - PRE0987

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