Pregatex-AT Tablet is a combination medicine indicated for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation.

Pregatex-AT Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Pregatex-AT Tablet helps to treat neuropathic pain. 

You are advised to take Pregatex-AT Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Pregatex-AT Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregatex-AT Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregatex-AT Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Pregatex-AT Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Pregatex-AT Tablet helps to treat neuropathic pain. 

• Weight gain
• Dry mouth
• Blurred vision
• Dizziness
• Tiredness
• Nausea
• Vomiting
• Diarrhoea
• Constipation

Do not take Pregatex-AT Tablet if you are allergic to any of its contents; if you have taken MAO inhibitors in the last 14days. Inform your doctor before taking Pregatex-AT Tablet if you have/had heart problems, bipolar syndrome, severe liver disease or porphyria. Consult your doctor if you are pregnant or breastfeeding. Pregatex-AT Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregatex-AT Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregatex-AT Tablet as it could lead to increased drowsiness and sleepiness.

Drug-Drug Interactions: Pregatex-AT Tablet may interact with antidepressants (duloxetine, sertraline, escitalopram), pain killers (fentanyl, hydrocodone, morphine, oxycodone, acetaminophen), anti-convulsant (topiramate), anti-anxiety (alprazolam), sedative-hypnotics (zolpidem), antihistamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), thyroid hormone (levothyroxine).

Drug-Food Interactions: Avoid alcohol consumption while taking Pregatex-AT Tablet as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Inform your doctor if you have suicidal tendency, angioedema, creatine kinase elevations, heart problems, depression, fits, pheochromocytoma (tumour of the adrenal gland), bone marrow suppression, tardive dyskinesia (involuntary facial movements), glaucoma, schizophrenia, bipolar disorder, thyroid problems, urinary retention, kidney or liver problems.

• DULOXETINE
• SERTRALINE
• ESCITALOPRAM
• FENTANYL
• HYDROCODONE
• ACETAMINOPHEN
• MORPHINE
• OXYCODONE
• TOPIRAMATE
• ALPRAZOLAM
• ZOLPIDEM
• DIPHENHYDRAMINE
• CETIRIZINE
• CYCLOBENZAPRINE
• LEVOTHYROXINE

• Include food rich in vitamin B and D in your diet.

• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

• Exercising regularly helps in improving overall health and combating pain.

• Rest well, and get plenty of sleep.

• Try taking a warm bath, as it can be soothing.

• Avoid smoking and alcohol consumption.

• Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

• Acupuncture can be helpful by stimulating pressure points.

• Using essential oils for massages can help increase circulation.

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).