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  3. Polyxx-E 3 Injection 1's

Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Polyxx-E 3 Injection is used to treat bacterial infections. It contains Colistimethate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as stomach upset, itching, rash, and fever. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Polyxx-E 3 Injection 1's, Pack of 1 SACHET
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Composition :

COLISTIMETHATE-3000000IU

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Polyxx-E 3 Injection

Polyxx-E 3 Injection belongs to a class of drugs called antibiotics used in the treatment of severe bacterial infections. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly. Polyxx-E 3 Injection does not work against infections caused by a virus.

Polyxx-E 3 Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Take Polyxx-E 3 Injection as prescribed by your doctor. You are advised to take Polyxx-E 3 Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dizziness, stomach upset, tingling, or difficulty in breathing. Most of these side effects of Polyxx-E 3 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Polyxx-E 3 Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Polyxx-E 3 Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Polyxx-E 3 Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Polyxx-E 3 Injection may cause confusion, vision problems, or dizziness.  If you are on dialysis, inform your doctor before taking Polyxx-E 3 Injection so that the dose may be reduced accordingly.

Uses of Polyxx-E 3 Injection

Treatment of Several bacterial infections

Directions for Use

Polyxx-E 3 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Polyxx-E 3 Injection contains Colistimethate, a narrow-spectrum antibiotic that is active against gram-negative bacteria. Polyxx-E 3 Injection binds to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria. Polyxx-E 3 Injection is used when other antibiotics are not suitable.

How Polyxx-E 3 Injection Works

Polyxx-E 3 Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Polyxx-E 3 Injection

  • Dizziness
  • Stomach upset
  • Tingling
  • Difficulty in breathing

What if I have taken an overdose of Polyxx-E 3 Injection

Use Polyxx-E 3 Injection only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, confusion, loss of balance/coordination, rapid eye movement, severe numbness/tingling, weak/shallow breathing, problems with speech, and loss of consciousness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Polyxx-E 3 Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Polyxx-E 3 Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Polyxx-E 3 Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Polyxx-E 3 Injection may cause confusion, vision problems, or dizziness. If you are on dialysis, inform your doctor before taking Polyxx-E 3 Injection so that the dose may be reduced accordingly. Inform your anesthetist that you are taking Polyxx-E 3 Injection as it may increase the effects of muscle relaxants used in general anesthesia. You are recommended to complete the full course of Polyxx-E 3 Injection as prescribed by your doctor for effective results.

Drug-Drug Interactions

verifiedApollotooltip
ColistinBCG vaccine
Critical
ColistinCisatracurium
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Polyxx-E 3 Injection 1's along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Polyxx-E 3 Injection 1's with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinCisatracurium
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Cisatracurium with Polyxx-E 3 Injection 1's may increase the risk of side effects of Cisatracurium.

How to manage the interaction:
Although there is a possible interaction of Cisatracurium with Polyxx-E 3 Injection 1's, it can be taken if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, Slurred speech, Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinRocuronium bromide
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Rocuronium bromide with Polyxx-E 3 Injection 1's may increase the side effects of Rocuronium bromide.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Rocuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinSuxamethonium
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Using Suxamethonium together with Polyxx-E 3 Injection 1's may increase the effects of Suxamethonium.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Suxamethonium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash Paresthesia (tingling or pricking sensation) Dizziness Slurred speech Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinStreptomycin
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Streptomycin with Polyxx-E 3 Injection 1's may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ColistinPancuronium
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Using Pancuronium with Polyxx-E 3 Injection 1's can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinGentamicin
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Co-administration of Polyxx-E 3 Injection 1's with Gentamicin can increase the levels and risk of Polyxx-E 3 Injection 1's side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Gentamicin, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinTobramycin
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Tobramycin with Polyxx-E 3 Injection 1's can increase the blood levels and risk of Polyxx-E 3 Injection 1's side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Tobramycin, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
ColistinPipecuronium bromide
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Coadministration of Pipecuronium bromide with Polyxx-E 3 Injection 1's may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and pipecuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinIohexol
Severe
How does the drug interact with Polyxx-E 3 Injection 1's:
Combining Polyxx-E 3 Injection 1's with Iohexol can increase the effect or side effects of Iohexol.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection 1's and Iohexol, you can take these medicines if prescribed by your doctor. However, if you experience vomiting, loss of appetite, irregular urination, swelling, shortness of breath, muscle cramps, or weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Polyxx-E 3 Injection to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like cheese, yogurt, kombucha, sauerkraut, and kimchi can restore the good bacteria of the intestine.
  • Include fiber-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet.
  • Make sure you drink plenty of water or other fluids every day while you are taking Polyxx-E 3 Injection.
  • Avoid alcohol consumption as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Polyxx-E 3 Injection Substitute

Substitutes safety advice

  • Colinios 3 MIU Injection 1's

    ₹1950.00per tablet

  • Eudomonas 3 MIU Injection 1's

    ₹2923.00per tablet

Product Substitutes

Info icon

Colinios 3 MIU Injection 1's

₹1950

Info icon

Eudomonas 3 MIU Injection 1's

₹2923

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Alcohol

Caution

Interaction of Polyxx-E 3 Injection with alcohol is unknown. Please consult a doctor before consuming alcohol while using Polyxx-E 3 Injection.

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Pregnancy

Caution

Polyxx-E 3 Injection is a category C pregnancy drug and is given to pregnant women only if it is essential. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Polyxx-E 3 Injection may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Polyxx-E 3 Injection may cause confusion, vision problems or dizziness. Therefore, avoid driving if you experience any of these symptoms after taking Polyxx-E 3 Injection.

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Liver

Caution

Take Polyxx-E 3 Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Polyxx-E 3 Injection with caution, especially if you have a history of Kidney diseases/conditions as Polyxx-E 3 Injection may affect kidney function. The dose may be adjusted by your doctor as required.

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Children

Caution

Polyxx-E 3 Injection should be used with caution in children and in doses as prescribed by a doctor. Special care should be taken in new-born and premature babies as kidneys are not developed fully.

FAQs

Polyxx-E 3 Injection is used to treat bacterial infections.
Polyxx-E 3 Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria.
You are not recommended to take Polyxx-E 3 Injection with gentamicin as co-administration of these two medicines may increase the risk of severe adverse effects such as kidney problems, hearing loss or respiratory depression especially in elderly people and in those who have preexisting kidney disease or who are dehydrated. However, please consult your doctor before taking Polyxx-E 3 Injection with other medicines.
Polyxx-E 3 Injection may cause dizziness as a common side effect. Avoid driving if you feel dizzy after taking Polyxx-E 3 Injection. However, if the condition persists or worsens, please consult a doctor.
Polyxx-E 3 Injection should be used with caution in patients receiving dialysis (the process of filtration and purification of blood using a machine). Therefore, if you are receiving dialysis, please inform your doctor before taking Polyxx-E 3 Injection so that the dose may be adjusted accordingly.
You are recommended to take Polyxx-E 3 Injection with extreme caution if you have kidney disease as it may worsen the condition. Regular monitoring of kidney functioning is recommended while taking Polyxx-E 3 Injection. Therefore, inform your doctor if you have any kidney problems before taking Polyxx-E 3 Injection.
Before taking Polyxx-E 3 Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Polyxx-E 3 Injection is given by a healthcare professional as an infusion over 30–60 minutes or as a rapid injection within 5 minutes into a vein. Do not self-administer.
Do not use Polyxx-E 3 Injection if you are allergic to its active substances or any other polymyxins (group of antibiotics to treat bacterial infection). If you are unsure, consult your doctor before receiving Polyxx-E 3 Injection.
Polyxx-E 3 Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Polyxx-E 3 Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Polyxx-E 3 Injection if you are pregnant.
Polyxx-E 3 Injection is safe when used as per the dose and duration advised by a doctor.
Polyxx-E 3 Injection causes side effects such as dizziness, stomach upset, tingling, and difficulty in breathing. However, these do not require any medical treatment and gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - POL0584

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Author Details

Doctor imageDoctor badge

Written By

Veda Maddala

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.5648.pdf
  2. https://www.drugs.com/cdi/colistimethate.html
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