Plermin Gel belongs to the class of platelet-derived growth factors (PDGFs) used to treat diabetic foot ulcers in people with good blood flow in the legs and feet. A diabetic foot ulcer is a common complication of diab­etes. Ulcers are formed due to the break down of skin tissue and exposure to underneath layers. Diabetic foot ulcers commonly develop under the big toes and balls of the feet. Also, they can affect the feet down to the bones.

Plermin Gel contains Becaplermin which works by stimulating the growth of cells involved in wound healing. Thereby, it helps to treat ulcers of the legs or foot in people with diabetes.

Plermin Gel is only for external use. Use Plermin Gel as prescribed by your doctor. You are advised to use Plermin Gel for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience burning at the site of application and red skin rash. Most of these side effects of Plermin Gel do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are known to be allergic to Plermin Gel or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please consult your doctor before using Plermin Gel . Avoid using Plermin Gel if you have a skin tumor at the site of the application. The size of the ulcer must be checked by your doctor every 1 to 2 weeks so that the dose may be adjusted according to the size of the ulcer.

Plermin Gel contains Becaplermin used to treat diabetic foot ulcers in people with good blood flow in the legs and feet. Plermin Gel stimulates the growth of cells involved in wound healing. Thereby, it helps to treat ulcers of the legs or feet in people with diabetes. Plermin Gel is used along with other ulcer care practices such as good wound care to treat diabetic foot ulcers.

• Burning at the site of application

• Red skin rash

If you are known to be allergic to Plermin Gel or any other medicines, please tell your doctor. Avoid using Plermin Gel if you have a skin tumor at the site of the application. The size of the ulcer must be checked by your doctor every 1 to 2 weeks so that the dose may be adjusted according to the size of the ulcer. You are recommended to cover the treated area with a gauze dressing moistened with saline. Avoid contact of Plermin Gel with mouth, eyes, or vagina. Do not touch the tip of the tube to the ulcer or any other surface. In case Plermin Gel comes in contact with these areas accidentally, rinse with warm water thoroughly. If you are pregnant or breastfeeding, please consult your doctor before using Plermin Gel .

Drug-Drug Interaction: No interactions found.

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have cancer, skin tumor or poor blood flow to lower legs and feet, please inform your doctor before taking Plermin Gel .

• Do not put weight on the affected leg and foot.

• Adequately trim your toenails but not too short.

• Regularly change your socks and wear proper-fitting shoes.

• Keep your feet dry and moisturized.

• Regularly wash your feet.

• Consult a doctor if you have corn and also for callus removal.

• Wear shoe inserts to prevent calluses and corns.

• Wear foot braces, compression wraps or casts to protect your feet.

Diabetic foot ulcers: It is a common complication of diab­etes. Ulcers are formed due to the breakdown of skin tissue and exposure of underneath layers. Diabetic foot ulcers commonly develop under the big toes and balls of the feet. Also, they can affect the feet down to the bones. The primary sign of diabetic foot ulcer is drainage from the foot that stains socks or leaks out in the shoe. Other symptoms include redness, irritation, unusual swelling, and odors from 1 or both feet. Sometimes, there may be no symptoms until the ulcer has become infected. Treatment includes medication and surgical procedures.