Plagerine-A Capsule is used for the prevention of heart attack and stroke. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is most often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). Signs of a heart attack include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.

Plagerine-A Capsule is composed of two medicines: Aspirin and Clopidogrel. These are blood thinners (anti-platelet) that prevent the formation of a clot in the blood vessels. Aspirin acts as a blood-thinning or anti-platelet agent in a low dose (about 75 mg) to prevent heart attack and stroke. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels). Plagerine-A Capsule helps in the free flow of blood, thereby preventing a heart attack, stroke, deep vein thrombosis (blood clot in the vein), and pulmonary embolism (blood clots in the arteries of the lungs).

Your doctor will advise you on how often you take your tablets based on your medical condition. The common side effects of Plagerine-A Capsule include abdominal pain, indigestion, diarrhoea, easy bruising, and nosebleeds. Plagerine-A Capsule is known to cause dizziness and blurry vision, so driving should be avoided. Most of these side effects of Plagerine-A Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping Plagerine-A Capsule may worsen your condition and increase the risk of a future heart attack. Let your doctor know if you are sensitive to clopidogrel or aspirin, have kidney/liver diseases, have bleeding issues (like peptic ulcer or brain haemorrhage), are pregnant or are planning to become pregnant or breastfeeding. The patient should inform the doctor that they are taking Plagerine-A Capsule before any surgery is scheduled or any new medicine is taken.

Plagerine-A Capsule is composed of Aspirin and Clopidogrel, which act as blood thinners (anti-platelet) and prevent the formation of a clot in the blood vessels. Aspirin acts as a blood-thinning or anti-platelet agent in a low dose (about 75 mg) to prevent heart attack and stroke. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels). Plagerine-A Capsule helps in the free flow of blood, thereby preventing heart attack, stroke, deep vein thrombosis (blood clot in the vein), and pulmonary embolism (blood clots in the arteries of the lungs).

• Abdominal pain

• Indigestion

• Diarrhoea

• Easy bruising

• Nosebleeds

• Increased bleeding tendency

You should avoid taking Plagerine-A Capsule if you are allergic to Plagerine-A Capsule . Let your doctor know if you have a medical condition that is causing bleeding such as a haemophilia, stomach ulcer or bleeding within your head or bowel. Caution is required before giving Plagerine-A Capsule to the liver or kidney problems patients. People affected with respiratory problems like asthma, rhinitis or nasal polyps should consult a doctor before intake of Plagerine-A Capsule . Plagerine-A Capsule is not recommended for the breastfeeding mother as it passes into the breast milk. The safety and effectiveness of Plagerine-A Capsule in children less than 12 years of age have not been established. 

Drug-Drug Interaction: Plagerine-A Capsule may interact with blood thinners (warfarin, heparin), anti-psychotics (fluoxetine, lithium), anti-diabetics (glibenclamide, repaglinide), anti-cancer drugs (methotrexate), gout medicines (probenecid), anti-epilepsy drugs (valproate, phenytoin), anti-inflammatory medication (ibuprofen), drugs that treat upset stomach (omeprazole), antifungals (fluconazole), and HIV drugs (ritonavir, cobicistat).

Drug-Food Interaction: Limit alcohol intake since it may cause a rise in blood pressure leading to heart diseases. Avoid fatty foods and control your cholesterol and triglyceride levels.

Drug-Disease Interaction: Brief your doctor if you have a medical history of allergic reactions to medicines, heart diseases, active bleeding disorders, asthma, a clot in an artery of your brain (ischaemic stroke), liver, and kidney diseases before taking Plagerine-A Capsule .

• WARFARIN
• HEPARIN
• FLUOXETINE
• LITHIUM
• GLIBENCLAMIDE
• REPAGLINIDE
• METHOTREXATE
• VALPROATE
• PHENYTOIN
• IBUPROFEN
• OMEPRAZOLE
• FLUCONAZOLE
• RITONAVIR
• COBICISTAT
• PROBENECID

• Take the medication as directed by the doctor and at regular intervals. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Plagerine-A Capsule .

• Keep your cholesterol and triglyceride levels under control.

• Eat at regular intervals, and maintain a healthy diet that includes fresh fruits, and vegetables.

• Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.

• Keep a check on your weight and exercise regularly to keep your heart healthy.

• Your doctor also guides you on how to notice and manage the early symptoms of detecting heart diseases. 

Let your doctor know that you are using Plagerine-A Capsule if you have a scheduled surgery since this medicine may increase the risk of bleeding.

A blood clot is a clump or aggregation of blood that changes from a liquid to a gel-like state. Clotting is a natural process that prevents you from losing too much blood in an accident, trauma, surgery or cut. When a clot forms inside the veins, it won’t always dissolve on its own and can become an even life-threatening situation.

Stroke: When our brain does not get sufficient oxygen and blood supply, it starts dying within a few minutes, leading to a heart attack or stroke.

Heart attack: It occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is most often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). During a heart attack (myocardial infarction), the blood supply which nourishes the heart with oxygen is cut off. This causes the heart muscle to die. Signs of a heart attack include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.