Pke 90mg/48mg/100mg Tablet is used to relieve musculoskeletal pain in the conditions of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time (acute) or long time (chronic).  

Pke 90mg/48mg/100mg Tablet is a combination of one antioxidant (Rutoside) and two enzymes (Trypsin and Bromelain). Rutoside is an antioxidant that prevents cell damage, reduces toxins, protects the body from damage caused by free radicals (toxins), and decreases swelling. Trypsin removes dead skin cells and allows the growth of healthy tissue. On the other hand, Bromelain is a pineapple extract that limits fibrin formation by reducing clots or plaque at the damaged/injured site. Together it reduces swelling and inflammation by producing substances in the body against pain and swelling. Thus, Pke 90mg/48mg/100mg Tablet helps in relieving edema (fluid overload) and inflammation and promotes wound healing. 

Take Pke 90mg/48mg/100mg Tablet with or without food as prescribed by your doctor and swallow whole with a glass of water. Do not crush, chew or break it. Your doctor will advise you how often you take your tablets based on your medical condition. In some cases, you may experience vomiting, nausea, diarrhea, rash, or mouth sores. Most of these side effects of Pke 90mg/48mg/100mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Pke 90mg/48mg/100mg Tablet or any other medicines, please tell your doctor. Avoid Pke 90mg/48mg/100mg Tablet in patients who are allergic to pineapple, carrot, papaya, fennel, and pollens. Pke 90mg/48mg/100mg Tablet is not recommended for pregnant women as it contains Bromelain, which may cause abortion or miscarriage. If you are pregnant or planning for pregnancy, please consult a doctor before taking Pke 90mg/48mg/100mg Tablet. Before undergoing any planned surgery, inform your doctor that you are taking Pke 90mg/48mg/100mg Tablet. It should be stopped a minimum of 2 weeks before surgery due to increased bleeding risk during and after surgery. If you have blood pressure problems, clotting or bleeding problems, infection, hematuria (blood in urine), hematemesis (vomiting blood), or kidney or liver disorders, inform your doctor before taking Pke 90mg/48mg/100mg Tablet.

Pke 90mg/48mg/100mg Tablet is a combination of one antioxidant (Rutoside) and two enzymes (Trypsin, Bromelain). Rutoside is an antioxidant (substances that prevent damage to cells) that works by protecting the body from damage caused by free radicals (unstable molecules produced by the body) and further decreases swelling. Trypsin removes dead skin cells and allows the growth of healthy tissue. In combination with Bromelain, Trypsin reduces swelling and inflammation by producing substances in the body against pain and swelling in the conditions of joint disorders like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.  

• Vomiting

• Nausea

• Diarrhea

• Rash

• Mouth sores

• Gastrointestinal discomfort

If you are allergic to Pke 90mg/48mg/100mg Tablet or any other medicines, please tell your doctor. People allergic to pineapple, carrot, papain, fennel, and pollen should avoid the intake of Pke 90mg/48mg/100mg Tablet. It is not recommended for pregnant women as it contains Bromelain, which may cause miscarriage, so if you are pregnant or planning for pregnancy, let your doctor know about this. If you are about to undergo any surgery, inform your doctor that you are taking Pke 90mg/48mg/100mg Tablet. It should be stopped a minimum of 2 weeks before surgery as Pke 90mg/48mg/100mg Tablet may increase the risk of bleeding during and after surgery. If you have blood pressure problems, clotting or bleeding problems, infection, hematuria (blood in urine), hematemesis (vomiting blood), kidney or liver disorders, inform your doctor before taking Pke 90mg/48mg/100mg Tablet.

Drug-Drug Interaction: Pke 90mg/48mg/100mg Tablet may have interaction with painkillers (aspirin, diclofenac, ibuprofen, naproxen), blood thinners (warfarin, clopidogrel, dalteparin, enoxaparin, heparin), antibiotics (amoxicillin, demeclocycline, minocycline, tetracycline), drugs used to dissolve blood clots (alteplase, reteplase, streptokinase), high blood pressure-lowering medicines (captopril, enalapril, fosinopril, lisinopril).

Drug-Food Interaction: Pke 90mg/48mg/100mg Tablet may interact with ginger, garlic, asafoetida, alfalfa, arnica, fenugreek, potato, soybean, licorice, red clover, celery, angelica, meadowsweet, quassia, willow,  chestnut, chamomile, and clover.

Drug-Disease Interaction: If you have blood pressure problems, clotting or bleeding problems, infection, hematuria (blood in urine), hematemesis (vomiting blood), kidney or liver disorders, inform your doctor before taking Pke 90mg/48mg/100mg Tablet.

• ASPIRIN
• DICLOFENAC
• IBUPROFEN
• NAPROXEN
• WARFARIN
• CLOPIDOGREL
• DALTEPARIN
• ENOXAPARIN
• HEPARIN
• AMOXICILLIN
• DEMECLOCYCLINE
• MINOCYCLINE
• TETRACYCLINE
• ALTEPLASE
• RETEPLASE
• STREPTOKINASE
• CAPTOPRIL
• ENALAPRIL
• FOSINOPRIL
• LISINOPRIL

• Include more glucosamine, chondroitin sulphate, Vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding, and swimming. You can also increase your muscle strength by lifting light weights.

• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

• In the chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize the level of chemicals called cytokines, which may increase inflammation.

• Your sitting posture is important, especially when have pain and inflammation condition. Try to sit little as possible, and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your hips and knees at a right angle. Besides this, you can use a footrest if required.

Pke 90mg/48mg/100mg Tablet must not be used by patients with severe inborn bleeding disorders like hemophilia, severe liver damage, and dialyzed patients. 

Osteoarthritis and rheumatoid arthritis: It is a chronic condition caused by wear and tear on the joints with sore/stiff joints, and pain worsens after activity or the end of the day. In rheumatoid arthritis, the immune system attacks musculoskeletal joints and other body parts with pain, fatigue, and swollen, warm, and inflamed-looking joints. Arthritis cannot be cured but can be managed.