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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:48 PM IST
Pimaquin 15mg Tablet is an antimalarial drug used for the treatment of malaria. It contains Primaquine, which kills the malaria parasite and stops the infection from spreading. It helps to prevent the relapse of malaria caused by plasmodium vivax and Plasmodium ovale strains of the parasite. It may cause common side effects such as rash, vomiting, headache, dizziness, stomach pain, nausea, itching, heartburn, and gastrointestinal discomfort.
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Prescription drug

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Composition

PRIMAQUINE-15MG

Manufacturer/Marketer

Shince Pharmaceuticals Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Pimaquin 15mg Tablet

Pimaquin 15mg Tablet belongs to the class 'anti-malarials' primarily used for the treatment of malaria. A disease caused by a plasmodium parasite, transmitted by the bite of infected mosquitoes. The severity of malaria varies based on the species of plasmodium. Symptoms are chills, fever and sweating, usually occurring a few weeks after being bitten. People travelling to areas where malaria is common typically take protective drugs before, during and after their trip. 

Pimaquin 15mg Tablet contains 'primaquine'. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading. In this way Pimaquin 15mg Tablet used for the prevention of relapse of malaria caused by plasmodium vivax and Plasmodium ovale strains of the parasite.

Pimaquin 15mg Tablet should be taken as prescribed by your doctor, preferably with a meal to avoid stomach upset and at fixed intervals every day for best results. The dose of Pimaquin 15mg Tablet can vary depending upon your condition and the severity of the infection. It is recommended to complete medicine and take this medicine as prescribed by your doctor before visiting a malaria-prone area. The common side effects of Pimaquin 15mg Tablet include rash, vomiting, headache, dizziness, hives, stomach pain, nausea, abdominal pain, itching, heartburn, gastrointestinal discomfort, upper abdominal pain. Everyone need not experience the above side effects. In case of any discomfort, stop the medicine and speak with your doctor.

Before starting Pimaquin 15mg Tablet, please inform your doctor if you are allergic to Pimaquin 15mg Tablet. Do not take Pimaquin 15mg Tablet on your own. Pimaquin 15mg Tablet is used in caution with Pregnant/breast-feeding mother. Pimaquin 15mg Tablet is not recommended in patients with heart disease, liver, kidney problems and rheumatoid-arthritis.

Uses of Pimaquin 15mg Tablet

Treatment of Malaria

Medicinal Benefits

Pimaquin 15mg Tablet belongs to the class 'anti-malarials' primarily used for the treatment of malaria. Pimaquin 15mg Tablet contains 'primaquine'. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading. In this way Pimaquin 15mg Tablet used for the prevention of relapse of malaria caused by plasmodium vivax and Plasmodium ovale strains of the parasite. Pimaquin 15mg Tablet can also be given in combination with clindamycin for the treatment of Pneumocystis carinii pneumonia (PCP).

Directions for Use

Take it with food to decrease the risk of stomach upset. Swallow it as a whole. Do not chew, crush or break it. Do not skip any doses and finish the full course of treatment even if you feel better.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pimaquin 15mg Tablet

  • Rash
  • Vomiting
  • Headache
  • Stomach pain
  • Dizziness
  • Lightheadedness
  • Hives
  • Dark-coloured urine
  • Abdominal pain
  • Confusion
  • Weakness
  • Itching
  • Heartburn
  • Nausea
  • Gastrointestinal discomfort
  • Upper abdominal pain

Drug Warnings

Before starting Pimaquin 15mg Tablet, please inform your doctor if you are allergic to Pimaquin 15mg Tablet. Do not take Pimaquin 15mg Tablet on your own. Pimaquin 15mg Tablet is used in caution with Pregnant/breast-feeding mother. Pimaquin 15mg Tablet is not recommended in patients of heart disease, liver, kidney problems and rheumatoid arthritis. Pimaquin 15mg Tablet is not recommended in patients of diabetes. Pimaquin 15mg Tablet is not recommended for use in acutely ill patients suffering from a systemic disease like rheumatoid arthritis and lupus erythematosus. There is a marked decrease in the number of granulocytes in such conditions. Pimaquin 15mg Tablet is also not recommended for use if you are receiving a medication that can cause anaemia or suppression of the immune system by affecting bone marrow cells as a side effect. Medicine is not recommended for use if you are consuming Quinacrine or any other combination medicine containing quinacrine (anti-malarial drug). Patients should avoid pregnancy during treatment. It is recommended to take this medicine for the entire prescribed duration even when symptoms improve or resolve. Failure to do so might result in drug resistance. Sexually active women can take effective Contraceptive pills and men should use a condom during and 3months after stopping the treatment. Pimaquin 15mg Tablet should be discontinued immediately when leukopenia (reduced white blood cells) occurs.

Drug Interactions

Drug-Drug Interaction: Pimaquin 15mg Tablet can interact with pain killers (aspirin),  antibiotics (ciprofloxacin),  antimalarials (quinacrine), corticosteroids (dexamethasone), anti-epileptic (Phenytoin), vitamins (cyanocobalamin, cholecalciferol, riboflavin, pyridoxine, thiamine, ascorbic acid).

Drug-Food Interaction: Limit the consumption of grapefruit or grapefruit juice with Pimaquin 15mg Tablet as it can significantly increase the level of this medicine in the blood. 

Drug-Disease Interaction: People affected with eye disorder (oculotoxicity), blood disease (porphyria), heart disease (arrhythmias), bone marrow suppression,  seizures, enzyme deficiency (G-6-PD deficiency), liver disease (hepatotoxicity), hemolytic anaemia should not take Pimaquin 15mg Tablet without doctors consultation.

Drug-Drug Interactions Checker List

  • CIPROFLOXACIN
  • ASPIRIN
  • PYRIMETHAMINE
  • TRIMETHOPRIM
  • PENICILLAMINE
  • PHENYTOIN
  • DEXAMETHASONE
  • CHOLECALCIFEROL
  • ASCORBIC ACID
  • RIBOFLAVIN (VITB2)
  • PYRIDOXINE (VITB6)
  • VALPROIC ACID
  • ACETAMINOPHEN

Habit Forming

No

Diet & Lifestyle Advise

  • Adequate nutrition is the key to improvement in malaria induced weakness.
  • It is important to allow the patient to eat regularly in small amounts to tolerate the food. 
  • Increase fluid and protein intake for malaria induced weight loss.
  • Proper rest and mosquito-free premises is important for the patient to recover
  • Avoid eating fried and processed foods, junk oily and spicy foods can aggravate nausea and can disturb the digestion process in the body.
  • High fibre foods like whole-grain cereals must be avoided by malaria patients. Instead, the intake of fruits and pulses should be increased as they provide adequate nutrition

Special Advise

  • Always take Pimaquin 15mg Tablet with meals for reduced gastric irritation.
  • Eye examination prior to and at 3–6 monthly intervals during use is required if patients are receiving Primaquine at continuous high doses for a longer duration.
  • It may cause low blood sugar level. Monitor your blood sugar level regularly, if you are diabetic.
  • When Pimaquin 15mg Tablet used long term, your doctor may monitor the amounts of the different types of blood cells in your blood regularly.

Disease/Condition Glossary

Malaria: It is a severe & fatal parasitic infection caused by a protozoan called Plasmodium. 4 types of parasites can infect humans with malaria: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria. Female anopheles mosquito bites cause it. If bitten by an infected mosquito (the Anopheles mosquito), malaria parasites are injected into the blood. These parasites then migrate to the liver where they multiply via the bloodstream. A patient doesn't feel sick at this period because the parasites are in the liver. Then the parasites leave the liver and enter the red blood cells where the parasites are developing and then the red blood cells burst, allowing them to transfer to another blood cell. The parasites release harmful chemicals into the bloodstream at this point and the patient begins to feel ill. Malaria leads to periodic fever-chills, anaemia, kidney failure and jaundice because of excessive red blood cell death due to plasmodium growth inside them.

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Alcohol

Caution

Interaction of Pimaquin 15mg Tablet with alcohol is unknown. It is advisable to consult your doctor before consumption.

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Pregnancy

Caution

Pimaquin 15mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations, if the benefits are more than the potential risks. Please consult your doctor.

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Breast Feeding

Caution

Pimaquin 15mg Tablet is recommended for use in breastfeeding women only after diagnostic tests are performed to confirm normal G6PD enzyme levels. Consult your doctor before using this medicine

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Driving

Caution

Pimaquin 15mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Pimaquin 15mg Tablet therapy is unlikely to cause liver injury in normal individuals but can trigger an acute worsening of porphyria in rare cases. Thus doctor's consultation is recommended before taking Pimaquin 15mg Tablet

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Kidney

Caution

Pimaquin 15mg Tablet administration impairs kidney function in a few cases, so a patient is recommended to consult a doctor before taking Pimaquin 15mg Tablet.

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Children

Caution

Safe to use in children (<12) yet dose adjustment by a doctor will be done on the basis of age, weight and severity of the infection.

Country of origin

India
Other Info - PI92776

Author Details

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FAQs

Pimaquin 15mg Tablet is used for the treatment of malaria.
No, as there may be a risk of hemolysis in patients with G6PD deficiency. Doctors consultation is mandatory.
Pimaquin 15mg Tablet works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading. In this way Pimaquin 15mg Tablet used for the prevention of relapse of malaria caused by plasmodium vivax and Plasmodium ovale strains of the parasite.
Common side effects of Pimaquin 15mg Tablet include rash, vomiting, headache, dizziness, hives, stomach pain, nausea, abdominal pain, itching, heartburn, gastrointestinal discomfort, upper abdominal pain.
No, do not stop taking Pimaquin 15mg Tablet. It is recommended to take this medicine for the entire prescribed duration even when symptoms improve or resolve. Failure to do so might result in drug resistance and treating any subsequent infection with the same medicine would be very difficult.
No, Pimaquin 15mg Tablet is not safe to use in heart problems. The use of this medicine may increase the risk of irregular heart rhythms. Therefore, it should be used with caution in patients with arrhythmias or any other heart diseases. Any symptoms of palpitations, difficulty in breathing should be reported to the doctor.
Pimaquin 15mg Tablet is contraindicated in patients taking medications that may cause haemolysis or depress the myeloid elements of the bone marrow. It should not be taken by pregnant women and acutely ill patients with conditions like granulocytopenia (rheumatoid arthritis or lupus), or those who have recently taken quinacrine, as it may increase the risk of toxicity.
You should tell your doctor if you are taking cephalosporins such as cefaclor, cephalexin, cefuroxime, penicillin, cefdinir, or cefpodoxime, levodopa, medications to treat cancer, methyldopa or quinidine, or if you are taking or planning to take vitamins, nutritional supplements, and herbal products. Let the doctor know if you have or have ever had haemolytic anaemia (a condition with an abnormally low number of RBC), rheumatoid arthritis, lupus erythematosus (a disease that occurs when the body's tissues are attacked by antibodies from its immune system), methemoglobinemia (a condition with defective red blood cells that are unable to carry oxygen to the tissues in the body), nicotinamide adenine dinucleotide (NADH) deficiency (a genetic condition), glucose-6-phosphate dehydrogenase (G6PD) deficiency (a genetic condition) and if you are pregnant or breastfeeding.
Yes, Pimaquin 15mg Tablet is safe if it is taken in the dose and duration prescribed by the doctor. Therefore, take Pimaquin 15mg Tablet exactly prescribed by the doctor based on your medical condition.
If you have missed the dose, take it as soon as you remember and if it's already time for the next dose, skip the missed one and take the scheduled dose. Do not double the dose.
Swallow Pimaquin 15mg Tablet as a whole with water; do not crush or chew it. Pimaquin 15mg Tablet should be taken with food to decrease the risk of stomach upset.
Pimaquin 15mg Tablet should be taken exactly as prescribed by the doctor, preferably with a meal to minimize stomach discomfort. For best results, take it at the same time every day.
No, Pimaquin 15mg Tablet is not an antibiotic. It belongs to the group of medications called antimalarials used to treat and prevent malaria caused by the Plasmodium parasite. It is also used to prevent relapse of malaria caused by Plasmodium vivax and Plasmodium ovale.
Pimaquin 15mg Tablet may impair kidney function in a few cases. Therefore, consult the doctor before taking Pimaquin 15mg Tablet if you have any kidney problems.
Yes, Pimaquin 15mg Tablet may cause drowsiness as a side effect. Avoid driving and operating machinery if you feel drowsiness and there is no evidence suggesting that Pimaquin 15mg Tablet has any effect on blood pressure.

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