PG Nac-50mg Capsule belongs to a class of non-steroidal anti-inflammatory drugs used to reduce pain and swelling in the joints associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone). Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time. The arthritis symptoms include joint pain, stiffness, redness, tenderness, swelling in and around joints, and reduced movement of joints.

PG Nac-50mg Capsule is a combination drug containing diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

Take PG Nac-50mg Capsule as prescribed by your doctor. Depending on your medical conditions, you are advised to take PG Nac-50mg Capsule for as long as your doctor has prescribed it for you. You may experience diarrhoea, stomach/abdominal pain, nausea, heartburn, drowsiness, and dizziness. Most of the side effects of PG Nac-50mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before using the PG Nac-50mg Capsule , tell your doctor if you have had a heart attack or stroke, stomach or bowel disorder, liver disease, porphyria ( inherited blood disorder), asthma, high blood pressure, diabetes, and stomach or intestinal bleeding. Do not take PG Nac-50mg Capsule if you are a pregnant or breastfeeding woman. Consumption of alcohol should be avoided during the treatment with PG Nac-50mg Capsule as it may lead to an increased risk of liver damage. PG Nac-50mg Capsule is not recommended for use in children. Limit alcoholic beverages while on this medication.

PG Nac-50mg Capsule is used to treat aches and pains and musculoskeletal and joint pain problems due to arthritis. PG Nac-50mg Capsule contains diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

• Diarrhea
• Stomach/abdominal pain
• Nausea
• Heartburn
• Difficulty sleeping
• Ulcers in the stomach or intestines
• Drowsiness
• Dizziness
• Indigestion

Consumption of alcohol should be avoided during the treatment with PG Nac-50mg Capsule . Patients with stomach ulcers, gastric bleeding, heart failure, and high blood pressure should not take PG Nac-50mg Capsule . If pregnant or breastfeeding, do not take PG Nac-50mg Capsule without talking with the doctor. PG Nac-50mg Capsule is not recommended for children below 18 years old. Seek medical help immediately if you have signs of a heart attack or stroke. Stop using PG Nac-50mg Capsule and call your doctor immediately if you notice heart problems, kidney problems, liver problems, or stomach bleeding signs.

Drug-Drug Interactions: Other pain medications such as aspirin, ibuprofen, naproxen, celecoxib, indomethacin, meloxicam, blood clotting agents (warfarin), blood pressure-lowering agents (hydrochlorothiazide), antacids, Lithium (used to treat mental problems).

Drug-Food Interactions: Do not consume alcohol along with PG Nac-50mg Capsule to avoid unpleasant side effects like gastric bleeding.

Drug-Disease Interactions: Peptic ulcers, gastric bleeding, severe heart failure, liver/kidney problems, diabetes, asthma, and high blood pressure.

• ASPIRIN
• IBUPROFEN
• NAPROXEN
• CELECOXIB
• INDOMETHACIN
• MELOXICAM
• WARFARIN
• HYDROCHLOROTHIAZIDE
• LITHIUM

• Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
• In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize the level of cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel to minimise pain at the back of your curve. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Osteoarthritis: Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age. The older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include past injuries such as torn cartilage, dislocated joints, and ligaments.

Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms include pain, swelling, stiffness, deformities, and loss of joint function.

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain usually starts in the lower back and can spread to the neck, damaged joints, or other parts of the body. Ankylosing spondylitis includes decreased flexibility, which usually leads to hunched-forward posture, pain, and back and joints.