PEPSIGARD P GEL belongs to a class of medication called gastrointestinal agents used to treat duodenal ulcers, nausea, and vomiting. Duodenal ulcer is a peptic ulcer that develops in the duodenum (first part of the small intestine) due to erosion of the stomach's protective lining. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

PEPSIGARD P GEL is a combination of two drugs: Sucralfate (gastrointestinal protectant) and Domperidone (antinausea agent). Sucralfate belongs to the protectants class which forms a protective layer over the ulcer and protects the stomach from an ulcer due to excess stomach acid, thereby healing it. Domperidone belongs to the dopamine antagonist class that works by blocking dopamine receptors that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Together they prevent ulcers, nausea, and vomiting.

Take PEPSIGARD P GEL as prescribed by your doctor. You are advised to take PEPSIGARD P GEL for as long as your doctor has prescribed it for you based on your medical condition. You may experience dry mouth, diarrhea, constipation, drowsiness, dizziness, or headache in some cases. Most of these side effects of PEPSIGARD P GEL do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to PEPSIGARD P GEL or any other medicines, please tell your doctor. PEPSIGARD P GEL is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established. If you are pregnant or breastfeeding, please inform your doctor before taking $your name. Drive only if you are alert as PEPSIGARD P GEL may cause drowsiness or dizziness. Avoid alcohol consumption as it may increase adverse effects or irritate the stomach lining. Avoid taking PEPSIGARD P GEL if you have black, tarry stools or notice blood in stools as these might be signs of bleeding in the stomach or intestines.

PEPSIGARD P GEL is a combination of two drugs: Sucralfate and Domperidone used to treat duodenal ulcers, nausea, and vomiting. Sucralfate is a protectant that forms a protective layer over the ulcer and protects the ulcer from stomach acid. Thereby, it allows healing. Domperidone is a dopamine antagonist that works by blocking dopamine receptors that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting. Also, domperidone acts as a prokinetic agent that increases muscle movements and contractions in the stomach. Thereby prevents vomiting and reduces bloating, nausea and fullness. 

• Dry mouth
• Diarrhoea
• Constipation
• Drowsiness
• Dizziness
• Headache

If you are allergic to PEPSIGARD P GEL or any other medicines, please tell your doctor. PEPSIGARD P GEL is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established. If you are pregnant or breastfeeding, please inform your doctor before taking PEPSIGARD P GEL . If you have a prolactinoma (tumor of the pituitary gland), kidney, liver, or heart problems, diabetes, high potassium levels in the blood, or black tarry stools, inform your doctor before taking PEPSIGARD P GEL . Drive only if you are alert as PEPSIGARD P GEL may cause drowsiness or dizziness. Avoid alcohol consumption as it may increase adverse effects or irritate the stomach lining. If you experience heart rhythm disorders like difficulty in breathing, loss of consciousness, or palpitations (strong or irregular heartbeat) while taking PEPSIGARD P GEL , contact your doctor immediately. You are not recommended to take antacids such as cimetidine and sodium bicarbonate with PEPSIGARD P GEL simultaneously as it may affect the absorption of PEPSIGARD P GEL . Avoid taking PEPSIGARD P GEL if you have black, tarry stools or notice blood in stools as these might be signs of bleeding in the stomach or intestines.

Drug-Drug Interaction: PEPSIGARD P GEL may interact with antifungals (voriconazole, fluconazole, ketoconazole), antidepressants (escitalopram, citalopram), anti-allergic drugs (mizolastine, mequitazine), vitamin (ascorbic acid), anticancer drugs (vandetanib, toremifene, vincamine), antimalarial drugs (halofantrine), antipsychotic drugs (sertindole, pimozide, haloperidol), antibiotics (moxifloxacin, pentamidine, clarithromycin, erythromycin, telithromycin), drugs for gastrointestinal disorders (prucalopride, cisapride, dolasetron), drugs for heart problems or high blood pressure (quinidine, amiodarone, disopyramide, dronedarone, sotalol, metoprolol, verapamil, dofetilide, diltiazem).

Drug-Food Interaction: PEPSIGARD P GEL may interact with grapefruit or grapefruit juice and increase the risk of adverse effects. Also, avoid alcohol consumption with PEPSIGARD P GEL as it may increase adverse effects such as irregular heartbeat, and drowsiness or may irritate the stomach lining.

Drug-Disease Interaction: If you have a prolactinoma (tumor of the pituitary gland), kidney,  liver, or heart problems, diabetes, high potassium levels in the blood, blockage in intestines, or black tarry stools, inform your doctor before taking PEPSIGARD P GEL .

• VORICONAZOLE
• FLUCONAZOLE
• KETOCONAZOLE
• ESCITALOPRAM
• CITALOPRAM
• MIZOLASTINE
• MEQUITAZINE
• ASCORBIC ACID
• VANDETANIB
• TOREMIFENE
• VINCAMINE
• HALOFANTRINE
• SERTINDOLE
• PIMOZIDE
• HALOPERIDOL
• MOXIFLOXACIN
• PENTAMIDINE
• CLARITHROMYCIN
• ERYTHROMYCIN
• TELITHROMYCIN
• PRUCALOPRIDE
• CISAPRIDE
• DOLASETRON
• QUINIDINE
• AMIODARONE
• DISOPYRAMIDE
• DRONEDARONE
• SOTALOL
• METOPROLOL
• VERAPAMIL
• DOFETILIDE
• DILTIAZEM

• Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over over-sweet and include more salty food, especially if you have been vomiting.
• If you like to vomit at a specific time, avoid eating your favorite food at that particular time as your taste for that food may get turned off.
• Include more cool beverages in your food like flavored gelatin, and carbonated beverages. And also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas or acidity.
• Drink any other liquid at least 30 minutes after eating food.
• If the smell of food makes you feel sick (vomit), do not cook food, which may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.
• Avoid sitting continuously as it may trigger acidity. Take 5 minutes for every hour by doing brisk walking or stretching.
• Avoid consumption of alcohol as it may increase adverse effects.

• PEPSIGARD P GEL may increase the risk of cardiac arrest and heart rhythm disorder, especially in the elderly aged over 60 years, when taken with other medicines.
• If you experience heart rhythm disorders like difficulty in breathing, loss of consciousness or palpitations (strong or irregular heartbeat) while taking PEPSIGARD P GEL , contact your doctor immediately.

Gastric ulcer: Peptic ulcers are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. Duodenal ulcer is a type of peptic ulcer that develops in the duodenum (the first part of the small intestine). 

Nausea and vomiting: Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). There is a receptor located in our brain known as the chemoreceptor zone (CTZ) that controls vomiting.