Pentasa 500 mg Tablet belongs to a class of drugs called 'anti-inflammatory drugs used to treat ulcerative colitis and Crohn’s disease. Ulcerative colitis is a type of chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus.

Pentasa 500 mg Tablet contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby, it reduces inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Take Pentasa 500 mg Tablet as prescribed. You are advised to use Pentasa 500 mg Tablet for as long as your doctor has recommended it for you based on your medical condition. In some cases, you may experience diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas). Most of these side effects of Pentasa 500 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Avoid taking Pentasa 500 mg Tablet if you are allergic to Mesalazine or any other medicines. Pentasa 500 mg Tablet should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Pentasa 500 mg Tablet . Avoid taking Pentasa 500 mg Tablet if you have severe kidney failure. If you have stomach pain or cramps, severe headache, fever or rash, stop taking Pentasa 500 mg Tablet immediately and consult a doctor.

Pentasa 500 mg Tablet contains Mesalazine, an anti-inflammatory drug used in the treatment of ulcerative colitis and Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helping in reducing inflammation (redness and swelling) in the intestines and providing relief from symptoms such as stomach pain or bleeding. Also, Pentasa 500 mg Tablet may prevent further episodes of ulcerative colitis.

Swallow the tablet as a whole with a glass of water. Do not crush, chew or break it.

• Diarrhoea
• Stomach pain
• Headache
• Nausea
• Vomiting
• Flatulence (gas)

If you are allergic to Mesalazine or any other medicines, please tell your doctor. Pentasa 500 mg Tablet should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Pentasa 500 mg Tablet . Avoid taking Pentasa 500 mg Tablet if you have severe kidney failure. Severe skin reactions such as toxic epidermal necrolysis (skin peeling and blistering) or Stevens-Johnson syndrome (a painful rash that spreads and blisters) can occur in some patients taking Pentasa 500 mg Tablet . Therefore, if you notice any skin reactions while taking Pentasa 500 mg Tablet , please consult a doctor immediately. If you have stomach pain or cramps, severe headache, fever or rash, stop taking Pentasa 500 mg Tablet immediately and consult a doctor. Avoid taking Pentasa 500 mg Tablet if you have had blood abnormalities or kidney problems while taking other medicines such as Sulphasalazine.

Drug-Drug Interactions: Inform your doctor if you are taking laxatives (lactulose), painkillers (aspirin, ibuprofen), immunosuppressants (azathioprine), or chemotherapy drugs (thioguanine, mercaptopurine).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: If you have a stomach ulcer, asthma or other lung problems, or any medical condition that can cause bleeding, liver, kidney or blood problems, inform your doctor before taking Pentasa 500 mg Tablet .

• LACTULOSE
• ASPIRIN
• IBUPROFEN
• AZATHIOPRINE
• THIOGUANINE
• MERCAPTOPURINE

• Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help in healing faster.
• Include olive oil and omega-3 fatty acids. Eat more fibre-rich foods such as fruits and vegetables.
• Limit dairy intake as your body may develop difficulty digesting certain dairy products when you are affected with Crohn’s disease, which leads to stomach cramps, diarrhoea or stomach upset.
• Drink plenty of water to prevent dehydration.

• Blood and urine tests are recommended before and during the treatment with Pentasa 500 mg Tablet to monitor the functioning of kidney, liver and blood.

Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. The factors involved in causing ulcerative colitis include immune disorders and environmental factors like viruses, bacteria or antigens, which may trigger the immune system and genes inherited from the parent.

Crohn’s disease: It is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss or loss of appetite.