Pef 400mg Tablet is used to treat infections caused by bacteria, including pneumonia, typhoid fever, urinary tract and gonorrhea (sexually transmitted disease). Bacterial infection is a condition in which bacteria grow in the body and cause infection. It can target any body part and multiple very quickly.

Pef 400mg Tablet contains Pefloxacin, an antibacterial that helps treat and prevent a wide range of bacterial infections. It is bactericidal and works by killing bacteria that cause infections.  It inhibits the repairing of bacterial cells and kills the bacteria, thereby preventing the further spread of the infection. Pef 400mg Tablet is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen).

Take Pef 400mg Tablet as prescribed by your doctor. You are advised to take Pef 400mg Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience nausea, headache, diarrhoea, vomiting, itching, and dizziness. Most of these side effects of Pef 400mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before starting Pef 400mg Tablet, please inform your doctor if you have any allergy (against any antibiotic) or kidney or liver problems. Do not take Pef 400mg Tablet on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Pef 400mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Pef 400mg Tablet as it causes increased dizziness. Pef 400mg Tablet may cause dizziness and vision problems, so be cautious while driving.

Pef 400mg Tablet belongs to the group of medicines called antibiotics used to treat bacterial infections of the skin, soft tissue, pneumonia, urinary tract, and gonorrhoea (sexually transmitted disease). It is also used for the treatment of typhoid fever. It is bactericidal in nature and works by killing bacteria that cause infections by preventing the formation of the cell wall required for living. It also prevents the repairing of bacterial cells. Overall, it kills the bacteria.

• Nausea
• Headache
• Diarrhoea
• Vomiting
• Itching
• Dizziness

Do not take Pef 400mg Tablet if you are allergic to any of its contents or if you had swelling or tearing of tendons while taking quinolone antibiotics. Pef 400mg Tablet is associated with an increased risk of tendon rupture and tendonitis (inflammation of the tendon) at all age groups; this risk is higher in patients older than 60years, who are taking corticosteroids and have had kidney, heart, or lung transplants. Consult your doctor immediately if you experience tendon pain, swelling, or inflammation while taking Pef 400mg Tablet. Pef 400mg Tablet should not be taken un for conditions like kidney and liver disease, epilepsy/fit disorder, and history of brain and spinal cord disease. Avoid contact with sunlight as it may cause severe sunburn. Immediately discontinue the Pef 400mg Tablet and inform your doctor if you get itchy skin, a rash, swelling of face and mouth, or have a problem in breathing. Do not take Pef 400mg Tablet on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Pef 400mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Pef 400mg Tablet as it causes increased dizziness. Pef 400mg Tablet may cause dizziness and vision problems, so be cautious while driving. Pef 400mg Tablet should not be recommended for children less than 12 years old.

Drug-Drug Interaction: This Pef 400mg Tablet may have an interaction with antidiabetic medicines (chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, and tolbutamide), blood thinners (aspirin, warfarin), medicines used in asthma (theophylline).

Drug-Food Interactions: Avoid dairy products such as milk and yoghurt while taking Pef 400mg Tablet as they might decrease the effectiveness of Pef 400mg Tablet.

Drug-Disease Interactions: Pef 400mg Tablet may have interactions with tendonitis (inflammation in tendons), diabetes, kidney, liver, and heart problems.

• CHLORPROPAMIDE
• GLIMEPIRIDE
• GLIPIZIDE
• GLYBURIDE
• METFORMIN
• TOLAZAMIDE
• TOLBUTAMIDE
• ASPIRIN
• WARFARIN
• THEOPHYLLINE

• Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Pef 400mg Tablet may increase nervousness, sleeplessness, and anxiety caused by caffeine.
• Probiotics should be taken after taking a full course of Pef 400mg Tablet in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine. 
• Include more fibre-enriched food in your diet. Fibre-rich foods can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Pef 400mg Tablet.
• Avoid intake of alcoholic beverages with Pef 400mg Tablet as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Pef 400mg Tablet in fighting off infections.

Tendon damage can occur after a few months of starting Pef 400mg Tablet treatment. The onset of symptoms and signs of the side effects may be delayed several months after stopping treatment. At the first sign of tendinitis (like painful swelling or inflammation), immediately stop taking Pef 400mg Tablet. The affected limbs should be appropriately treated (e.g., immobilization).

A bacterial infection is a condition in which harmful bacteria enter, multiply and infect our bodies. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. A few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. People with weak immune systems or taking immunosuppressive medicine can make them more prone to bacterial infection.