Pbren-D 75/30 Capsule belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Pbren-D 75/30 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Pbren-D 75/30 Capsule can be taken with or without food or as prescribed by your doctor. Pbren-D 75/30 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Pbren-D 75/30 Capsule should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Pbren-D 75/30 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pbren-D 75/30 Capsule effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

• Burning sensation
• Drowsiness
• Nausea
• Constipation
• Headache
• Dry mouth
• Increased sweating
• Loss of appetite

Pbren-D 75/30 Capsule should be avoided if you are allergic to any of the components in it. Do not stop taking Pbren-D 75/30 Capsule suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Pbren-D 75/30 Capsule may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Pbren-D 75/30 Capsule .

Drug-Drug Interactions: Pbren-D 75/30 Capsule may interact with antidepressants (moclobemide, paroxetine, fluoxetine, venlafaxine, clomipramine, and amitriptyline), antibiotic (linezolid), opioid analgesic (tramadol).

Drug-Food Interactions: Avoid alcohol consumption and smoking while using Pbren-D 75/30 Capsule .

Drug-Disease Interactions: Pbren-D 75/30 Capsule should be used with caution in patients with liver diseases, kidney diseases, heart problems, glaucoma (increased pressure in the eye), alcoholism, drug abuse, and suicidal tendencies.

• TRAMADOL
• FLUOXETINE
• MOCLOBEMIDE
• VENLAFAXINE
• AMITRIPTYLINE

• Exercise regularly, which helps in reducing pain.
• Rest well, and get enough sleep.
• Always take a warm bath, as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.

• Do not stop taking Pbren-D 75/30 Capsule suddenly, as it may cause withdrawal symptoms.
• Do frequent blood tests to check your fasting blood glucose, HbA1c, and total cholesterol (TC) levels to reduce any serious side effects.

Diabetic Neuropathy: Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. It mainly occurs in patients suffering from Type II Diabetes.

Fibromyalgia: It is a chronic condition with moderate pain and tenderness of the muscle all over the body. It mainly occurs due to physical or psychological stress. Symptoms may include fatigue, tiredness, trouble sleeping, anxiety, headache and depression.