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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Parozep 12.5 Tablet is used in the treatment of depression. It contains Clonazepam and Paroxetine, which increases levels of a calming chemical in the brain and also increases the serotonin hormone levels that improve mood, behaviour and prevent symptoms of depression. It may cause common side effects such as nausea, vomiting, diarrhoea, memory impairment, uncoordinated body movements, drowsiness, low sexual desire and delayed ejaculation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Icon Life Sciences

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Parozep 12.5 Tablet

Parozep 12.5 Tablet belongs to a group of medicines called ‘antidepressants’. It is used in the treatment of depression. Depression is a common mood disorder, which negatively affects a person's daily life described as feelings of sadness, loss, or anger. Depression symptoms can vary from mild to severe and can include: feeling sad, thoughts of death or suicide, loss of interest, weight loss or gain unrelated to dieting, trouble sleeping, loss of energy, feeling worthless or guilty and difficulty thinking.

Parozep 12.5 Tablet is a combination of two drugs: clonazepam and paroxetine. Clonazepam increases levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Paroxetine increases the serotonin hormone levels that improve mood, behaviour and prevent symptoms of depression.

You are advised to take Parozep 12.5 Tablet for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, memory impairment, uncoordinated body movements, drowsiness, low sexual desire and delayed ejaculation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking Parozep 12.5 Tablet for as long as your doctor has prescribed. Do not take Parozep 12.5 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Parozep 12.5 Tablet causes drowsiness, sleepiness, do not drive unless you are alert. Parozep 12.5 Tablet should not be given to children and adolescents aged 18 years for treating depression. Avoid consuming alcohol along with Parozep 12.5 Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Parozep 12.5 Tablet

Treatment of Depression

Directions for Use

Take Parozep 12.5 Tablet with or without food. Parozep 12.5 Tablet should be swallowed as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Parozep 12.5 Tablet is a combination of two drugs: clonazepam and paroxetine. Clonazepam is a benzodiazepine, which works by increasing levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Paroxetine is an antidepressant that increases the serotonin hormone levels that improve mood, behaviour, and prevent symptoms of depression.

How Parozep 12.5 Tablet Works

Parozep 12.5 Tablet is a combination of two drugs: clonazepam and paroxetine. Clonazepam increases levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Paroxetine increases the serotonin hormone levels that improve mood, behaviour and prevent symptoms of depression.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Parozep 12.5 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Memory impairment
  • Uncoordinated body movements
  • Drowsiness
  • Low sexual desire and delayed ejaculation

What if I have taken an overdose of Parozep 12.5 Tablet

Do not take more than the prescribed dose of Parozep 12.5 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Parozep 12.5 Tablet if you are allergic to Parozep 12.5 Tablet or any other ingredients in it. Tell your doctor if you are taking antidepressants, antipsychotic medication, antihypertensives, or pain medication. Talk to your doctor if you have a history of seizures, bipolar disorder, suicide attempts, or schizophrenia. Patients with liver diseases, diabetes, heart disease, lung disease and bleeding disorders should use Parozep 12.5 Tablet with caution. Please do not stop the treatment abruptly as it can cause withdrawal reactions. Parozep 12.5 Tablet is not recommended to use in children and adolescents under 18 years of age as it increases suicidal tendencies in this population. Consult your doctor immediately if you experience suicidal thoughts such as killing or harming yourself while on this medication. Do not take Parozep 12.5 Tablet if you are pregnant or breastfeeding unless prescribed. Parozep 12.5 Tablet causes drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with Parozep 12.5 Tablet as it could lead to increased drowsiness and dizziness.

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
ParoxetineLinezolid
Critical

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Taking Parozep 12.5 Tablet 10's with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineLinezolid
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Using Linezolid together with Parozep 12.5 Tablet 10's can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Linezolid is not recommended but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineSelegiline
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
When Parozep 12.5 Tablet 10's is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Selegiline can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
ParoxetineProcarbazine
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Using procarbazine together with Parozep 12.5 Tablet 10's can increase the risk of a serious condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Procarbazine is not recommended, but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, or blurred vision contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineMetoclopramide
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Using Metoclopramide with Parozep 12.5 Tablet 10's can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Metoclopramide with Parozep 12.5 Tablet 10's is not recommended, as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.
ParoxetinePimozide
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Combining Parozep 12.5 Tablet 10's with Pimozide can effect the rhythm of the heart

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Pimozide is not recommended, but should be taken if advised by a doctor. However, if you experience chest tightness, irregular heartbeat, blurred vision and nausea contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineFurazolidone
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Taking Furazolidone with Parozep 12.5 Tablet 10's can increase the risk of side effects

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Furazolidone is not recommended, but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, or blurred vision contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineTranylcypromine
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Using tranylcypromine with Parozep 12.5 Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Taking Parozep 12.5 Tablet 10's with Tranylcypromine is not recommended, but should be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineThioridazine
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Coadministration of Parozep 12.5 Tablet 10's with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Thioridazine with Parozep 12.5 Tablet 10's is not recommended, but should be taken if advised by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ParoxetineEliglustat
Critical
How does the drug interact with Parozep 12.5 Tablet 10's:
Coadministration of Parozep 12.5 Tablet 10's with eliglustat can increase the risk of irregular heart rhythm

How to manage the interaction:
Although there is an interaction between Parozep 12.5 Tablet 10's and Eliglustat, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy and well-balanced diet. 
  • Do not take stress as it may aggravate your condition.
  • Limit alcohol intake and quit smoking.
  • Engage in social activities frequently as it may improve self-esteem and confidence. 
  • Limit caffeine intake.
  • Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters. 
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosts self-esteem, and provides restful sleep.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

Yes

Therapeutic Class

ANTIDEPRESSANT

Parozep 12.5 Tablet Substitute

Substitutes safety advice
  • Zaptra 12.5 Capsule 10's

    28.22per tablet
  • Panazep 12.5 Tablet 10's

    20.34per tablet
  • Panezep 12.5 mg Tablet 10's

    by AYUR

    20.34per tablet
  • Pari CR Plus Tablet 15's

    by AYUR

    18.84per tablet
  • XET CR PLUS 12.5MG CAPSULE

    20.88per tablet
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Alcohol

Caution

Avoid consumption of alcohol while taking Parozep 12.5 Tablet as it may cause an increased sedative effect.

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Pregnancy

Unsafe

Parozep 12.5 Tablet may cause toxic effects to the fetus. So, it is not recommended for use in women who are pregnant or planning to become pregnant.

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Breast Feeding

Caution

Parozep 12.5 Tablet should be used with caution in breastfeeding mothers. Your doctor may advise you to stop breastfeeding while taking this medication.

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Driving

Caution

Do not drive or operate heavy machinery as Parozep 12.5 Tablet may cause drowsiness.

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Liver

Caution

Parozep 12.5 Tablet should be used with caution in patients with severe liver impairment. Dose adjustments may be required in such cases.

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Kidney

Caution

Parozep 12.5 Tablet should be used with caution in patients with kidney problems. Dose adjustments may be required in such cases. If you have any concerns regarding the use of Parozep 12.5 Tablet in patients with kidney problems, please consult a doctor.

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Children

Caution

Parozep 12.5 Tablet should not be used in children unless prescribed by a child specialist.

FAQs

Parozep 12.5 Tablet is used in the treatment of depression.
Parozep 12.5 Tablet causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you experience these symptoms after taking Parozep 12.5 Tablet .
Parozep 12.5 Tablet causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.
Do not discontinue Parozep 12.5 Tablet without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually continue taking Parozep 12.5 Tablet for as long as prescribed. Moreover, stopping this medicine suddenly may result in withdrawal symptoms. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Parozep 12.5 Tablet .
Parozep 12.5 Tablet may cause decreased sex-drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.
Dry mouth could be a side-effect of Parozep 12.5 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Some patients experienced increased suicidal thoughts or actions in the first few months of the treatment with Parozep 12.5 Tablet . Report to your doctor immediately if you notice any changes in your behaviour or mood while on this medication.
Yes, the use of Parozep 12.5 Tablet can cause sleepiness as a side effect. It's important to avoid driving or operating heavy machinery until you know how Parozep 12.5 Tablet affects you.
No, it's not safe to drink alcohol while taking Parozep 12.5 Tablet . Alcohol can increase the sedative effects of Parozep 12.5 Tablet , leading to increased drowsiness and dizziness. It's best to avoid alcohol to prevent these increased side effects.
Parozep 12.5 Tablet typically takes several weeks to show full effects, but it may differ from person to person. However, it’s important to complete the full course of treatment as prescribed by your doctor.
Store the Parozep 12.5 Tablet at room temperature protected from light and moisture. Keep it out of reach of children.
The common side effects of Parozep 12.5 Tablet are nausea, vomiting, diarrhoea, memory impairment, uncoordinated body movements, drowsiness, low sexual desire and delayed ejaculation. If any of these side effects persist or worsen, please consult doctor.

Country of origin

India

Manufacturer/Marketer address

12Th Floor Devika Towernehru Tower Nehru Place New Delhi South Delhi Dl 110019 In
Other Info - PAR0763

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