PANGRAF CAPSULE 5MG is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

PANGRAF CAPSULE 5MG contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take PANGRAF CAPSULE 5MG as prescribed. You are advised to use PANGRAF CAPSULE 5MG for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of PANGRAF CAPSULE 5MG do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using PANGRAF CAPSULE 5MG. Avoid alcohol consumption with PANGRAF CAPSULE 5MG. Drive only if you are alert, as PANGRAF CAPSULE 5MG may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking PANGRAF CAPSULE 5MG. PANGRAF CAPSULE 5MG may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

PANGRAF CAPSULE 5MG contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. PANGRAF CAPSULE 5MG suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

• Nausea
• Diarrhoea
• Headache
• Kidney problems
• Infection
• Constipation
• Fever
• High blood pressure

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using PANGRAF CAPSULE 5MG. Avoid alcohol consumption with PANGRAF CAPSULE 5MG. Drive only if you are alert, as PANGRAF CAPSULE 5MG may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking PANGRAF CAPSULE 5MG. PANGRAF CAPSULE 5MG may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking PANGRAF CAPSULE 5MG, you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interaction: Inform your doctor if you are taking immunosuppressant (cyclosporine, sirolimus), anti-HIV drugs (nelfinavir), anticonvulsants (phenytoin), antifungals (itraconazole, ketoconazole, voriconazole), antibiotics (erythromycin, clarithromycin), diuretics (triamterene, amiloride) and other medicines. 

Drug-Food Interaction: PANGRAF CAPSULE 5MG may interact with St. John’s Wort (a herbal supplement to treat depression). Avoid taking grapefruit and grapefruit juice with PANGRAF CAPSULE 5MG as it may cause serious side effects. Also, avoid consumption of alcohol with PANGRAF CAPSULE 5MG.

Drug-Disease Interaction: If you have liver, kidney or heart problems, inform your doctor before taking PANGRAF CAPSULE 5MG.

• CYCLOSPORINE
• SIROLIMUS
• NELFINAVIR
• PHENYTOIN
• ITRACONAZOLE
• KETOCONAZOLE
• VORICONAZOLE
• ERYTHROMYCIN
• CLARITHROMYCIN
• TRIAMTERENE
• AMILORIDE

• Include fruits and vegetables in your daily routine.
• Follow a vitamin-C-rich diet.
• Reduce salt intake.
• Eat a handful of walnuts and almonds every day.
• Reduce intake of unhealthy cholesterol and fats.
• Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

• Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
• Maintain a low-fat and low-salt diet.
• Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
• Stay hydrated by drinking sufficient water and other fluids.
• Avoid alcohol consumption.
• Avoid grapefruit and grapefruit juice. 

Regular blood tests and certain other tests are recommended while taking PANGRAF CAPSULE 5MG to check blood sugar levels, kidney functioning and potassium levels in the blood.

Organ rejection: It occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it. Organ rejection may be hyperacute (occurs in minutes to hours), acute (occurs within the first few months), or chronic (occurs after a year or time beyond). The symptoms of organ rejection may vary based on the type of organ transplant you have had. However, if you experience pain, fever, or other signs of illness, contact your doctor immediately.