Panef LS 75mg/20mg Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD), acidity, indigestion, heartburn, and peptic ulcers. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity and heartburn. Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.

Panef LS 75mg/20mg Capsule is a combination of two drugs, namely: Pantoprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Pantoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Panef LS 75mg/20mg Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

You are advised to take Panef LS 75mg/20mg Capsule as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as headache, nausea, vomiting, gas, dry mouth, dizziness and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking Panef LS 75mg/20mg Capsule if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Panef LS 75mg/20mg Capsule may cause osteoporosis and hypomagnesemia (low magnesium levels). Consult your doctor if you are pregnant or breastfeeding. Panef LS 75mg/20mg Capsule may cause drowsiness and dizziness, so drive only if you are alert. Panef LS 75mg/20mg Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Panef LS 75mg/20mg Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Panef LS 75mg/20mg Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease, acidity, indigestion heartburn, and peptic ulcers. Panef LS 75mg/20mg Capsule is a combination of two drugs, namely: Pantoprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Pantoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Panef LS 75mg/20mg Capsule helps in preventing acid reflux, thereby provides relief from acidity and heartburn.

• Headache
• Nausea
• Vomiting
• Gas
• Dry mouth
• Dizziness
• Diarrhoea

Do not take Panef LS 75mg/20mg Capsule if you are allergic to any of its contents. Inform your doctor if you have a history of pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or severe kidney and liver impairment. Panef LS 75mg/20mg Capsule may cause osteoporosis (weak and brittle bones) and hypomagnesemia (low magnesium levels) on long-term treatment. Consult your doctor if you are pregnant or breastfeeding. Panef LS 75mg/20mg Capsule may cause dizziness and drowsiness, so drive only if you are alert. Panef LS 75mg/20mg Capsule should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Panef LS 75mg/20mg Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Drug-Drug Interactions: Panef LS 75mg/20mg Capsule may interact with medicines such as anti-fungal (ketoconazole, itraconazole, posaconazole) anti-cancer (erlotinib), blood thinner (warfarin, phenprocoumon), anti-HIV (atazanavir), a drug used to treat rheumatoid arthritis, psoriasis, and cancer (methotrexate), anti-depressant (fluvoxamine), antibiotic (rifampicin), and herbal supplement (St John’s wort).

Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, intestinal obstruction, pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, hypomagnesemia (low levels of magnesium).

• KETOCONAZOLE
• ITRACONAZOLE
• POSACONAZOLE
• WARFARIN
• ATAZANAVIR
• METHOTREXATE
• FLUVOXAMINE
• RIFAMPICIN

• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

• Eat smaller meals more often.

• Maintain a healthy weight by regular exercising.

• Avoid lying down after eating.

• Avoid tight-fitting clothes.

• Maintain a healthy weight by regular exercising.

• Practise relaxation techniques and avoid stress by doing yoga or meditation.

• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.

• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn, and peptic ulcers.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. 

Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. 

Indigestion: Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea and vomiting.