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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Palonee 0.25Mg/5Ml Inj is used to prevent nausea and vomiting during chemotherapy. It contains Palonosetron, which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone) located in the brain. Thus, it prevents nausea and vomiting. Common side effects of Palonee 0.25Mg/5Ml Inj are diarrhoea, constipation, dizziness or headache.
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Composition :

PALONOSETRON-0.05MG

Manufacturer/Marketer :

Neetco Biopharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Palonee 0.25Mg/5Ml Inj

Palonee 0.25Mg/5Ml Inj belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Palonee 0.25Mg/5Ml Inj contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Palonee 0.25Mg/5Ml Inj will be administered by a healthcare professional; do not self-administer. In some cases, you may experience diarrhoea, constipation, dizziness or headache. Most of these side effects of Palonee 0.25Mg/5Ml Inj do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Palonee 0.25Mg/5Ml Inj or any other medicines, please tell your doctor. Palonee 0.25Mg/5Ml Inj may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Palonee 0.25Mg/5Ml Inj. Drive only if you are alert as Palonee 0.25Mg/5Ml Inj may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Uses of Palonee 0.25Mg/5Ml Inj

Treatment of Nausea and vomiting

Directions for Use

Palonee 0.25Mg/5Ml Inj will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Palonee 0.25Mg/5Ml Inj contains Palonosetron which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting during chemotherapy.

How Palonee 0.25Mg/5Ml Inj Works

Palonee 0.25Mg/5Ml Inj contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Palonee 0.25Mg/5Ml Inj

  • Diarrhoea
  • Constipation
  • Dizziness
  • Headache

What if I have taken an overdose of Palonee 0.25Mg/5Ml Inj

As Palonee 0.25Mg/5Ml Inj is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Palonee 0.25Mg/5Ml Inj may cause bluish colour of the fingernails, lips, skin, palms, or nail beds, collapse, gasping to breathe, paleness of the skin, and seizures.

Drug Warnings

If you are allergic to Palonee 0.25Mg/5Ml Inj or any other medicines, please tell your doctor. Palonee 0.25Mg/5Ml Inj may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Palonee 0.25Mg/5Ml Inj. Drive only if you are alert as Palonee 0.25Mg/5Ml Inj may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Drug-Drug Interactions

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PalonosetronZiprasidone
Critical
PalonosetronVenlafaxine
Severe

Drug-Drug Interactions

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PalonosetronZiprasidone
Critical
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
Combining Palonee 0.25Mg/5Ml Inj with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Palonee 0.25Mg/5Ml Inj is not recommended, please consult your doctor before taking it.
PalonosetronVenlafaxine
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
When venlafaxine is taken with Palonee 0.25Mg/5Ml Inj, it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Palonee 0.25Mg/5Ml Inj, you can take these medicines together if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
PalonosetronBuspirone
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
Using Buspirone together with Fenfluramine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Co- administration of buspirone along with Palonee 0.25Mg/5Ml Inj can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
PalonosetronDoxepin
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
The combined use of Palonee 0.25Mg/5Ml Inj and doxepin can increase the risk of serotonin syndrome(A condition in which a chemical called serotonin builds up in your body) and increase the risk of irregular heart rhythms.

How to manage the interaction:
Co-administration of Palonee 0.25Mg/5Ml Inj and Doxepin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, diarrhoea, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PalonosetronAmitriptyline
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
Combining Palonee 0.25Mg/5Ml Inj with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Palonee 0.25Mg/5Ml Inj and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
PalonosetronAmiodarone
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
Coadministration of Amiodarone with Palonee 0.25Mg/5Ml Inj can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Palonee 0.25Mg/5Ml Inj together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PalonosetronVilazodone
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
When Vilazodone is taken with Palonee 0.25Mg/5Ml Inj, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Palonee 0.25Mg/5Ml Inj, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
PalonosetronHydroxychloroquine
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
The combined use of Palonee 0.25Mg/5Ml Inj and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of palponosetron and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PalonosetronPentazocine
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
Taking Palonee 0.25Mg/5Ml Inj with Pentazocine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Palonee 0.25Mg/5Ml Inj, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
PalonosetronClomipramine
Severe
How does the drug interact with Palonee 0.25Mg/5Ml Inj:
The combined use of Palonee 0.25Mg/5Ml Inj with clomipramine can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhea) to severe (muscle rigidity, fever, and seizures)).

How to manage the interaction:
Although taking clomipramine and Palonee 0.25Mg/5Ml Inj together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS
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Alcohol

Caution

The interaction of alcohol with Palonee 0.25Mg/5Ml Inj is unknown. Please consult a doctor before consuming alcohol with Palonee 0.25Mg/5Ml Inj.

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Pregnancy

Consult your doctor

Palonee 0.25Mg/5Ml Inj is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please inform your doctor if you are pregnant.

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Breast Feeding

Consult your doctor

Please inform your doctor before taking Palonee 0.25Mg/5Ml Inj if you are breastfeeding. Palonee 0.25Mg/5Ml Inj is given to breastfeeding women only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Palonee 0.25Mg/5Ml Inj may cause tiredness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking Palonee 0.25Mg/5Ml Inj.

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Liver

Safe if prescribed

Palonee 0.25Mg/5Ml Inj may be safe to use in patients with liver problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Kidney

Safe if prescribed

Palonee 0.25Mg/5Ml Inj may be safe to use in patients with kidney problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Children

Caution

Palonee 0.25Mg/5Ml Inj may be given to children above 1 month in doses as advised by a doctor based on the child's body weight.

FAQs

Palonee 0.25Mg/5Ml Inj is used to treat nausea and vomiting.
Palonee 0.25Mg/5Ml Inj contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
You are not recommended to take erythromycin with Palonee 0.25Mg/5Ml Inj as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Palonee 0.25Mg/5Ml Inj.
Palonee 0.25Mg/5Ml Inj may cause constipation as a side effect. It is not necessary for everyone taking Palonee 0.25Mg/5Ml Inj to experience this side effect. However, if the condition persists or worsens, please consult a doctor.
Palonee 0.25Mg/5Ml Inj should be used with caution in patients suffering from heart problems as it may worsen the condition. Therefore, inform your doctor if you have any heart problems before taking have Palonee 0.25Mg/5Ml Inj so that the dose may be adjusted appropriately.

Country of origin

India

Manufacturer/Marketer address

College, Ground Floor F-7, Bhadale Complex, Gate No. 1152, Raisoni College Rd, Wagholi, Pune, Maharashtra 412207
Other Info - PAL0199

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