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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Paliris LA 75 mg PFS Injection 0.75 ml is used for the treatment of schizophrenia and schizoaffective disorder in adults. It contains Paliperidone, which works by blocking the effects of chemical messengers in the brain (i.e., dopamine and serotonin), thereby helping improve mood, behaviour and thoughts. Thus, it elevates the symptoms of the disease and prevents them from recurring. Common side effects of Paliris LA 75 mg PFS Injection 0.75 ml are injection site reactions, sleepiness or drowsiness, feeling restlessness or needing to be constantly moving, dizziness, abnormal muscle movements including tremors (shaking), uncontrolled involuntary movements, shuffling and abnormal movements of your eyes.
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Whats That

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Synonym :

PALIPERIDONE PALMITATE

Composition :

PALIPERIDONE-75MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Paliris LA 75 mg PFS Injection 0.75 ml

Paliris LA 75 mg PFS Injection 0.75 ml belongs to a group of medicines called 'antipsychotics' used for the treatment of schizophrenia and schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants. Schizophrenia is a mental condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Paliris LA 75 mg PFS Injection 0.75 ml contains 'Paliperidone' that works by blocking the effects of chemical messengers in the brain (i.e., dopamine and serotonin), thereby helping improve mood, behaviour and thoughts. Paliris LA 75 mg PFS Injection 0.75 ml elevates the symptoms of the disease and prevents them from recurring.

Paliris LA 75 mg PFS Injection 0.75 ml is for intramuscular injection only. It should be given by experienced healthcare professionals. In some cases, you may experience common side effects such as injection site reactions, sleepiness or drowsiness, feeling restlessness or needing to be constantly moving, dizziness, abnormal muscle movements including tremor (shaking), uncontrolled involuntary movements, shuffling and abnormal movements of your eyes. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Paliris LA 75 mg PFS Injection 0.75 ml is restricted to use in people who are sensitive to paliperidone, risperidone, or any excipients in the formulation. Keep your doctor informed about your health condition and medicines to rule out any side effects. Before using Paliris LA 75 mg PFS Injection 0.75 ml, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Paliris LA 75 mg PFS Injection 0.75 ml is recommended not to use in children. Avoid consuming alcohol with Paliris LA 75 mg PFS Injection 0.75 ml as it could lead to increased drowsiness and dizziness. Paliris LA 75 mg PFS Injection 0.75 ml may impair your ability to make judgements, think clearly, or respond fast. Do not drive, operate heavy machinery, or engage in any other risky activity.

Uses of Paliris LA 75 mg PFS Injection 0.75 ml

Treatment of Schizophrenia

Directions for Use

For intramuscular injection only. It must be administered only by a healthcare professional.

Medicinal Benefits

Paliris LA 75 mg PFS Injection 0.75 ml belongs to a group of medicines called antipsychotics used to treat schizophrenia in adults. Paliris LA 75 mg PFS Injection 0.75 ml improves mood and behaviour in people with an imbalance of chemicals known as neurotransmitters in their brains. Thus, Paliris LA 75 mg PFS Injection 0.75 ml relieves psychotic symptoms like delusions, hallucinations, confusion, disturbing thoughts and lack of self-awareness.

How Paliris LA 75 mg PFS Injection 0.75 ml Works

Paliris LA 75 mg PFS Injection 0.75 ml contains 'Paliperidone' that works by blocking the effects of chemical messengers in the brain (i.e., dopamine and serotonin), thereby helping improve mood, behaviour and thoughts. Paliris LA 75 mg PFS Injection 0.75 ml elevates the symptoms of the disease and prevents them from recurring.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Paliris LA 75 mg PFS Injection 0.75 ml

  • Dementia-related psychosis
  • Stroke
  • Dementia-Related psychosis
  • Neuroleptic malignant syndrome
  • QT prolongation
  • Tardive dyskinesia (involuntary movements)
  • Metabolic changes orthostatic hypotension and syncope
  • Falls
  • Leukopenia or Neutropenia (low levels of white blood cells)
  • Agranulocytosis
  • Hyperprolactinemia
  • Potential for cognitive and motor impairment
  • Seizures
  • Dysphagia (swallowing difficulties)
  • Priapism (prolonged erection of the penis)
  • Disruption of body temperature regulation
  • Dry mouth
  • Abdominal pain/Discomfort
  • Nausea
  • Diarrhoea
  • High fever
  • Severe muscle stiffness
  • Confusion
  • Loss of consciousness
  • Changes in your breathing, heartbeat and blood pressure

What if I have taken an overdose of Paliris LA 75 mg PFS Injection 0.75 ml

As Paliris LA 75 mg PFS Injection 0.75 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Paliris LA 75 mg PFS Injection 0.75 ml may cause obtundation, seizures, and dystonic reactions of the head and neck following an overdose, which may create a risk of aspiration with induced emesis.

Drug Warnings

Let your doctor know before prescribing Paliris LA 75 mg PFS Injection 0.75 ml if you are sensitive to paliperidone, risperidone, or any excipients in the formulation. Keep your doctor informed about your health condition and medicines to rule out any side effects. Before using the Paliris LA 75 mg PFS Injection 0.75 ml, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Paliris LA 75 mg PFS Injection 0.75 ml is recommended not to use in children. Avoid consuming alcohol with Paliris LA 75 mg PFS Injection 0.75 ml as it could lead to increased drowsiness and dizziness. Paliris LA 75 mg PFS Injection 0.75 ml has the potential to impair your capacity to make judgements, think clearly, or respond swiftly. Avoid being dehydrated or overheated.

Drug-Drug Interactions

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PaliperidoneZiprasidone
Critical
PaliperidoneChloroquine
Severe

Drug-Drug Interactions

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PaliperidoneZiprasidone
Critical
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Using Paliris LA 75 mg PFS Injection 0.75 ml with Ziprasidone can increase the risk of irregular heart rhythm,.

How to manage the interaction:
Taking Ziprasidone with Paliris LA 75 mg PFS Injection 0.75 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PaliperidoneChloroquine
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Taking chloroquine and Paliris LA 75 mg PFS Injection 0.75 ml together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Paliris LA 75 mg PFS Injection 0.75 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PaliperidoneBupropion
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Bupropion is capable of causing seizures (fits), and combining it with Paliris LA 75 mg PFS Injection 0.75 ml, may enhance the risk.

How to manage the interaction:
Co-administration of bupropion along with Paliris LA 75 mg PFS Injection 0.75 ml can lead to an interaction, it can be taken if advised by a doctor. While taking these medications, you should avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
PaliperidoneNilotinib
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Combining Paliris LA 75 mg PFS Injection 0.75 ml and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Paliris LA 75 mg PFS Injection 0.75 ml and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PaliperidoneHydroxychloroquine
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
The combined use of Paliris LA 75 mg PFS Injection 0.75 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Paliris LA 75 mg PFS Injection 0.75 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PaliperidoneMoxifloxacin
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Using Moxifloxacin together with Paliris LA 75 mg PFS Injection 0.75 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Paliris LA 75 mg PFS Injection 0.75 ml together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeats, dizziness, trouble breathing call a doctor right away. Do not stop using any medications without a doctor's advice.
PaliperidonePhenytoin
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Coadministration of Phenytoin and Paliris LA 75 mg PFS Injection 0.75 ml may reduce the blood levels of Paliris LA 75 mg PFS Injection 0.75 ml.

How to manage the interaction:
Co-administration of Phenytoin with Paliris LA 75 mg PFS Injection 0.75 ml can result in an interaction, but it can be taken if your doctor has advised it. When taken together, the doctor can recommend other options that won't cause any problems. Do not stop using any medications without a doctor's advice.
PaliperidoneAmiodarone
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
Coadministration of Amiodarone with Paliris LA 75 mg PFS Injection 0.75 ml can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Paliris LA 75 mg PFS Injection 0.75 ml together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PaliperidoneDisopyramide
Severe
How does the drug interact with Paliris LA 75 mg PFS Injection 0.75 ml:
The combined use of Paliris LA 75 mg PFS Injection 0.75 ml and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Paliris LA 75 mg PFS Injection 0.75 ml and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain proper weight by following a healthy diet.
  • Exercise regularly as it helps in less cognitive decline and brain volume loss.
  • Avoid smoking and alcohol consumption.
  • Try to avoid stress by practising meditation or yoga.
  • Include fruits and vegetables in your diet as they contain antioxidants.
  • Eat nutritious food as it helps in cognitive stimulation.
  • Limit foods with high cholesterol and saturated fats.
  • Cut down on sugar, salt and processed foods.
  • Drink plenty of water.
  • Follow a healthy lifestyle as it helps in improving overall health and possibly protects the brain.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Paliris LA 75 mg PFS Injection 0.75 ml Substitute

Substitutes safety advice
  • Invega Sustenna 75mg Injection 1's

    5438.40per tablet
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Alcohol

Caution

Avoid consumption of alcohol while taking Paliris LA 75 mg PFS Injection 0.75 ml as it may cause increased drowsiness and lower your blood pressure.

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Pregnancy

Caution

Paliris LA 75 mg PFS Injection 0.75 ml is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Paliris LA 75 mg PFS Injection 0.75 ml.

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Breast Feeding

Caution

Caution should be exercised. Paliris LA 75 mg PFS Injection 0.75 ml is not recommended for use in breastfeeding unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Paliris LA 75 mg PFS Injection 0.75 ml.

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Driving

Unsafe

Paliris LA 75 mg PFS Injection 0.75 ml may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities.

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Liver

Caution

Inform your doctor if you have a liver impairment. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

The safety and efficacy of Paliris LA 75 mg PFS Injection 0.75 ml are not established in children under the age of 18 years.

FAQs

Paliris LA 75 mg PFS Injection 0.75 ml is used to treat Schizophrenia.
Paliris LA 75 mg PFS Injection 0.75 ml works by balancing the chemical messengers called neurotransmitters and blocking the effect of dopamine and serotonin located in the brain, thereby helping in improving mood, behaviour and thoughts.
Paliris LA 75 mg PFS Injection 0.75 ml may cause metabolic changes: So it is recommended to monitor for hyperglycemia/diabetes mellitus, dyslipidemia and weight gain. If you experience any major changes inform the doctor immediately.
Paliris LA 75 mg PFS Injection 0.75 ml may cause an increase in blood glucose (sugar) levels. So, regular monitoring of blood sugar levels is advised while taking Paliris LA 75 mg PFS Injection 0.75 ml. Diabetes patients should discuss with a doctor before taking Paliris LA 75 mg PFS Injection 0.75 ml.
Yes, orthostatic hypotension could be a side-effect of Paliris LA 75 mg PFS Injection 0.75 ml. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Paliris LA 75 mg PFS Injection 0.75 ml are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
Paliris LA 75 mg PFS Injection 0.75 ml may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly.
Dry mouth could be a side-effect of Paliris LA 75 mg PFS Injection 0.75 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Paliris LA 75 mg PFS Injection 0.75 ml is known to cause increased mortality in people who are elderly with dementia. So, please inform your doctor if you have dementia; before starting Paliris LA 75 mg PFS Injection 0.75 ml.
The side effects of Paliris LA 75 mg PFS Injection 0.75 ml include injection site reactions, dizziness, sleepiness or drowsiness, uncontrolled involuntary movements, abnormal muscle movements including tremor, restlessness and abnormal movements of eyes. If these side effects persist or worsen, please consult your doctor.
No, Paliris LA 75 mg PFS Injection 0.75 ml is not a narcotic.
Yes, Paliris LA 75 mg PFS Injection 0.75 ml is an atypical antipsychotic.
Yes, Paliris LA 75 mg PFS Injection 0.75 ml may cause weight gain. Therefore, follow a healthy diet to maintain proper weight during treatment with Paliris LA 75 mg PFS Injection 0.75 ml. If you have any concerns regarding this, discuss with your doctor.
Paliris LA 75 mg PFS Injection 0.75 ml may cause priapism (prolonged and/or painful erection), which may lead to erectile dysfunction. Therefore, you are advised to follow your doctor’s instructions regarding its use.
Paliris LA 75 mg PFS Injection 0.75 ml may stay in our system/body for around 4 to 8 months.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - PAL0261

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