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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:31 PM IST
Palborest 100 Tablet is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains palbociclid which works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include weakness, loss of appetite, infections and dry skin.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Msn Laboratories Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Palborest 100 Tablet

Palborest 100 Tablet belongs to the group of anti-cancer drugs used to treat certain types of breast cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body. Breast cancer is cancer that forms in the cells of the breast. It can form in the lobules, ducts or tubules of the breast or in the breast tissue itself.

Palborest 100 Tablet contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Palborest 100 Tablet is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer. 

Take Palborest 100 Tablet as prescribed. In some cases, Palborest 100 Tablet may cause certain common side effects such as weakness, loss of appetite, infections and dry skin. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen. 

It is advisable to inform the doctor if you are allergic to any of its components. Do not take Palborest 100 Tablet if you are pregnant or breastfeeding. Palborest 100 Tablet may cause tiredness, so drive only if you are alert. Palborest 100 Tablet is not recommended for use in children below 18years. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Palborest 100 Tablet

Treatment of Breast Cancer

Medicinal Benefits

Palborest 100 Tablet is an anti-cancer drug used in the treatment of a particular type of breast cancer that is hormone receptor-positive and human epidermal growth factor receptor-2-negative. Palborest 100 Tablet works by blocking the production of proteins called cyclin-dependent kinase 4 and 6 that are responsible for cell growth and division. By blocking them, Palborest 100 Tablet nips cell growth in the bud and prevents cancer cells from spreading further. Thus, Palborest 100 Tablet helps treat breast cancer.

Directions for Use

Take Palborest 100 Tablet preferably with a meal. Swallow it as a whole with water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Palborest 100 Tablet

  • Loss of appetite
  • Dry skin
  • Weakness
  • Infection
  • Hair loss
  • Fever
  • Inflammation of the mouth and lips

Drug Warnings

Do not take St. John's wort or grapefruit/grapefruit juice with Palborest 100 Tablet. It is advisable to inform the doctor if you are allergic to any of its components. Do not take Palborest 100 Tablet if you are pregnant or breastfeeding. Palborest 100 Tablet may cause tiredness, so drive only if you are alert. Palborest 100 Tablet is not recommended for use in children below 18years. If you experience any signs or symptoms of infections, inform your doctor. Keep your doctor informed about your health condition and medications to rule out any interactions. Consult your doctor immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing or shortness of breath as it could be an indication of lung inflammation

Drug Interactions

Drug-DrugInteractions: Palborest 100 Tablet may interact antiviral/anti-HIV drug (lopinavir, ritonavir, nelfinavir, telaprevir, saquinavir), antidepressant (St John’s wort and nefazodone), antifungals (voriconazole, itraconazole, ketoconazole, posaconazole), antibiotics (clarithromycin, telithromycin) anti-rheumatoid drug (abatacept), heart medicine (quinidine), anti-gout medicine (colchicine), anaesthetics (alfentanyl and fentanyl), immunosuppressants (tacrolimus, cyclosporine), antipsychotics (pimozide) and anti-migraine drugs (dihydroergotamine, ergotamine).

Drug-Food Interactions: Palborest 100 Tablet may interact with grapefruit and grapefruit juice.

Drug-Disease Interactions: Palborest 100 Tablet should be used with caution in patients with a known hypersensitivity disorder, HIV, epilepsy, lactose intolerance, kidney disease, liver disease, lung or breathing disorders, hypertension, diabetes, heart disease, gout or a disease of the veins.

Drug-Drug Interactions Checker List

  • RITONAVIR
  • NELFINAVIR
  • SAQUINAVIR
  • LOPINAVIR
  • TELAPREVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • POSACONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ABATACEPT
  • QUINIDINE
  • COLCHICINE
  • ALFENTANIL
  • FENTANYL
  • TACROLIMUS
  • CYCLOSPORINE
  • PIMOZIDE
  • ERGOTAMINE

Habit Forming

No

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Special Advise

  • Discuss contraception with your doctor while taking Palborest 100 Tablet.
  • People on treatment with Palborest 100 Tablet should use additional contraception (barrier method such as condoms). Contraception should be continued 3 weeks post-treatment for women and 14 weeks post-treatment for men.
  • You may want to consider sperm storage before starting Palborest 100 Tablet. Seek counsel on the same from a qualified healthcare individual and/or sperm bank. 
  • Regular complete blood count monitoring is advised.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer that develops in breast cells. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm. 

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Alcohol

Caution

It is not recommended to use alcohol with Palborest 100 Tablet. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Palborest 100 Tablet is not recommended for use in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Palborest 100 Tablet is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Palborest 100 Tablet may cause tiredness and lethargy, which may affect your ability to drive. Do not drive if you experience any side effects after using Palborest 100 Tablet.

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Liver

Caution

Exercise caution before using Palborest 100 Tablet in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Palborest 100 Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Palborest 100 Tablet is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

Country of origin

India

Manufacturer/Marketer address

Msn Laboratories Pvt.Ltd., Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - PAL0237

Author Details

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FAQs

Palborest 100 Tablet belongs to the group of anti-cancer drugs used to treat certain types of breast cancer.
Palborest 100 Tablet works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.
Do not stop taking Palborest 100 Tablet on your own. You are advised to take Palborest 100 Tablet for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Palborest 100 Tablet.
A fibroadenoma is a benign state. Palborest 100 Tablet is indicated only in case of cancers. Please consult your doctor in case of any concerns.
Palborest 100 Tablet can reduce fertility in men. Therefore, consider sperm preservation before starting Palborest 100 Tablet if you wish to father a child in the future. Effects on female fertility have not been established. Please consult your doctor before using Palborest 100 Tablet.
Palborest 100 Tablet may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.
Palborest 100 Tablet is a type of targeted cancer drug. It is a treatment for breast cancer that is oestrogen receptor-positive (ER+) and human epidermal growth factor receptor-negative (HER2 -).
The duration of taking Palborest 100 Tablet varies from person to person. You take it in cycles (21 days on, 7 days off.), and as long as it's working and manageable, you continue the treatment. Your healthcare team will monitor your progress and adjust the treatment plan as needed.
Most side effects associated with Palborest 100 Tablet are temporary and can be effectively managed. However, certain side effects may persist or have a lasting impact in some cases. Common reversible side effects include fatigue, nausea, and hair loss, which typically resolve once treatment is stopped. In rare instances, more serious and potentially irreversible side effects may occur, such as permanent hair loss, increased infection risk, or heart problems. Regular monitoring and open communication with your healthcare team are essential to mitigate these risks and address any concerns that may arise during treatment.
Yes, Palborest 100 Tablet treatment requires blood count monitoring. If neutropenia is mild in the first six cycles, monitor blood counts every 3 months afterwards. This monitoring schedule helps healthcare providers track potential changes in blood counts and adjust treatment accordingly.
Take Palborest 100 Tablet exactly as your healthcare provider tells you. Swallow the capsule whole with water on an empty stomach at the same time each day. Follow the treatment schedule.
While using Palborest 100 Tablet, birth control is necessary to prevent pregnancy. Female patients must take a pregnancy test before starting treatment and use birth control during treatment and for at least 3 weeks after the final dose. Male patients, along with their partners, should also use birth control during treatment and for 3 months after the final dose. It's crucial to inform your doctor if you're pregnant, plan to become pregnant, or plan to father a child so they can guide you on the appropriate measures to take.
While women's fertility may not be affected, Palborest 100 Tablet can decrease fertility in men. Men taking palbociclib may want to talk to their treatment team about sperm preservation before starting treatment.
In some cases, side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment: fever, chills, or signs of infection; difficulty breathing or shortness of breath; cough with or without mucus; chest pain; dizziness; fast, irregular, or pounding heartbeat; weakness; unusual bleeding or bruising; nosebleeds; or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, as well as skin blistering, peeling, or redness.

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