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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Oxabenz-50 Injection is used to treat Colon and rectal cancer. It contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer. Sometimes, Oxabenz-50 Injection may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Whats That

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Composition :

OXALIPLATIN-2MG/ML

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Oxabenz-50 Injection

Oxabenz-50 Injection belongs to the group of medicines called platinum-containing antineoplastic agents used alone or in combination with other anti-cancer medicines to treat cancer of the large bowel/intestine (advanced colon or colorectal cancer).

Oxabenz-50 Injection contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

In some cases, Oxabenz-50 Injection may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Oxabenz-50 Injection if you are breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Oxabenz-50 Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Oxabenz-50 Injection

Treatment of Colon and rectal cancer

Directions for Use

Oxabenz-50 Injection will be administered by a qualified physician; do not self-administer.

Medicinal Benefits

Oxabenz-50 Injection contains Oxaliplatin, which belongs to the group of medicines called platinum-containing antineoplastic agents used to treat stage III colon cancer after complete removal of the primary tumour and metastatic cancer of the colon and rectum. It is used in combination with other anti-cancer medicines, such as 5-fluorouracil and folinic acid. Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer. Oxabenz-50 Injection may also be used with other medicines to prevent colon cancer from spreading in patients who have had surgery to remove the tumour.

How Oxabenz-50 Injection Works

Oxabenz-50 Injection contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Oxabenz-50 Injection

  • Mild nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Peripheral neuropathy
  • Fatigue
  • Back pain
  • Stomach pain

What if I have taken an overdose of Oxabenz-50 Injection

As Oxabenz-50 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Oxabenz-50 Injection may cause chest pain, diarrhea, numbness or tingling in the fingers or toes, slowed breathing, slowed heartbeat, shortness of breath, tightening of the throat, vomiting, and wheezing.

Drug Warnings

Do not use Oxabenz-50 Injection if you are allergic to any of its components, if you are breastfeeding, have a low blood cell count, have severe kidney problems, tingling and numbness in the fingers/toes, and have difficulty performing fragile tasks, such as buttoning clothes. Inform the doctor if you ever suffered an allergic reaction to platinum-containing medicines, have mild/moderate kidney problems, liver problems or abnormal liver function tests during therapy, or heart disorders like prolongation of the QT interval (abnormal electrical signal), an irregular heartbeat, or a family history of heart problems. Seek immediate medical attention if you experience symptoms of an allergic reaction (rash, itching, hives, reddening of the skin, hoarseness, difficulty breathing or swallowing, feeling as if your throat is closing, dizziness, swelling of the lips and tongue, lightheadedness, or fainting), unpleasant sensation in the throat, rhabdomyolysis (muscle pain and swelling), nerve problems (sensitivity to cold temperature or cold objects, pain, tingling or burning sensation), Posterior Reversible Encephalopathy Syndrome (headache, confusion, seizures, vision problems), myelosuppression (chills or shivering, burning or pain on urination, pain on swallowing, sore throat, cough with mucus, persistent diarrhoea), lung problems (shortness of breath, wheezing, cough), or bleeding problems (vomit that looks like coffee grounds or bloody vomit, pink or brown urine, weakness, dizziness, changes in speech, confusion, unexplained bleeding or dark-coloured/tarry stools).

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
OxaliplatinIvabradine
Severe

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Oxabenz-50 Injection 25 ml with Ziprasidone can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Ziprasidone is not recommended, please consult your doctor before taking it.
OxaliplatinIvabradine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using ivabradine together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Ivabradine, you can take these medicines together if prescribed by your doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
OxaliplatinInfliximab
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Infliximab with Oxabenz-50 Injection 25 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Oxabenz-50 Injection 25 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinEfavirenz
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Oxabenz-50 Injection 25 ml with Efavirenz can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinChloroquine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using chloroquine together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Oxabenz-50 Injection 25 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
OxaliplatinHaloperidol
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Co-administration of Oxabenz-50 Injection 25 ml and Haloperidol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Oxabenz-50 Injection 25 ml and Haloperidol can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
OxaliplatinDisopyramide
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
The combined use of Oxabenz-50 Injection 25 ml and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Oxabenz-50 Injection 25 ml and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
OxaliplatinEtanercept
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
When Etanercept is used with Oxabenz-50 Injection 25 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
OxaliplatinCladribine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Cladribine with Oxabenz-50 Injection 25 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
OxaliplatinMoxifloxacin
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using Moxifloxacin together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Moxifloxacin, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience dizziness, shortness of breath, or heart palpitations (irregular heartbeat). Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Oxabenz-50 Injection Substitute

Substitutes safety advice
  • Oxabenz-100 Injection 50 ml

    95.81per tablet
  • Caitplatin 50 mg Injection 25 ml

    88.00per tablet
  • Caitplatin 100 mg Injection 50 ml

    115.80per tablet
  • Oxakem 50 Injection 25 ml

    129.20per tablet
  • Oxalee 50 Injection 25 ml

    142.00per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Oxabenz-50 Injection. Please consult your doctor.

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Pregnancy

Unsafe

Oxabenz-50 Injection may cause foetal harm. Therefore, avoid becoming pregnant during treatment with Oxabenz-50 Injection.

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Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment with Oxabenz-50 Injection and for three months after the last dose.

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Driving

Caution

Oxabenz-50 Injection may cause dizziness or vision problems. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Oxabenz-50 Injection.

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Kidney

Caution

Oxabenz-50 Injection should not be used if you have severe kidney disease. If you have mild or moderate kidney disease, inform your doctor before receiving Oxabenz-50 Injection.

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Children

Unsafe

Oxabenz-50 Injection is not recommended for children as safety and effectiveness have not been established.

FAQs

Oxabenz-50 Injection is used to treat Colon and rectal cancer.
Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer.
Oxabenz-50 Injection may have an anti-fertility effect, which could be irreversible. Therefore, male patients should seek medical advice on the conservation of sperm prior to treatment with Oxabenz-50 Injection.
Avoid drinking or eating anything colder than room temperature. Do not touch any cold objects, wash your hands in cold water, go near air conditioners or freezers, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of Oxabenz-50 Injection. Wear a hat, gloves, and a scarf, and cover your mouth and nose if you must go outside in cold weather.
Oxabenz-50 Injection may decrease the ability to fight infections due to reduced white blood cells. Stay away from sick people during treatment with Oxabenz-50 Injection.
Oxabenz-50 Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a clinical setting.
The common side effects of Oxabenz-50 Injection are mild nausea, vomiting, diarrhoea, headache, peripheral neuropathy, fatigue, back pain, and stomach pain. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

India

Manufacturer/Marketer address

Plot No 107, Epip Phase 1, Jharmajri, Baddi
Other Info - OXA0128

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