Oropyrin Plus 500mg/250mg Tablet belongs to the class of drugs known as analgesics and muscle relaxants. It is primarily indicated for the relief of severe skeletal muscle spasms associated with painful conditions such as low back pain, sprain, strain, myalgia (muscle pain), headache, traumatic muscle injuries, cervical root and disc syndrome, torticollis (neck muscle contractions), and fibrositis (pain and inflammation of muscles). Muscle spasms are involuntary contractions of muscle, which can be painful.

Oropyrin Plus 500mg/250mg Tablet is a combination of two drugs: Paracetamol (Analgesic) and Chlorzoxazone (Muscle relaxant). Paracetamol works by inhibiting the synthesis of prostaglandins, which are responsible for pain and inflammation. Chlorzoxazone acts on the brain and spinal cord centres, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms. Together, Oropyrin Plus 500mg/250mg Tablet helps in relieving musculoskeletal pain.

You are advised to take Oropyrin Plus 500mg/250mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as gastrointestinal disturbances, nausea, dizziness, drowsiness, weakness, and light-headedness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Oropyrin Plus 500mg/250mg Tablet contains paracetamol; do not take any other medicines containing paracetamol along with Oropyrin Plus 500mg/250mg Tablet unless prescribed. Consult your doctor if you are pregnant or breastfeeding. Oropyrin Plus 500mg/250mg Tablet is not recommended for children as safety has not been established. Avoid consuming alcohol along with Oropyrin Plus 500mg/250mg Tablet as it could increase the risk of stomach bleeding. Oropyrin Plus 500mg/250mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Oropyrin Plus 500mg/250mg Tablet is a combination of two drugs: Paracetamol and Chlorzoxazone. Oropyrin Plus 500mg/250mg Tablet is used to relieve pain and stiffness caused by muscle strains and sprains. Oropyrin Plus 500mg/250mg Tablet is indicated for the relief of severe skeletal muscle spasms associated with painful conditions such as low back pain, sprains, strains, myalgia (muscle pain), headache, traumatic muscle injuries, cervical root and disc syndrome, torticollis (neck muscle contractions), and fibrositis (pain and inflammation of muscles). Paracetamol is an analgesic that inhibits prostaglandin synthesis and is responsible for pain and inflammation. Chlorzoxazone is a muscle relaxant that acts on the brain and spinal cord centres, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms. Together, Oropyrin Plus 500mg/250mg Tablet helps in relieving pain due to muscle spasms.

• Gastrointestinal disturbances
• Nausea
• Dizziness
• Drowsiness
• Weakness
• Light-headedness 

Do not take Oropyrin Plus 500mg/250mg Tablet if you are allergic to any of its contents. Oropyrin Plus 500mg/250mg Tablet contains paracetamol, do not take any other products containing paracetamol along with Oropyrin Plus 500mg/250mg Tablet. Inform your doctor before taking Oropyrin Plus 500mg/250mg Tablet if you have heart, kidney or liver impairment. Consult your doctor if you are pregnant or breastfeeding. Oropyrin Plus 500mg/250mg Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Oropyrin Plus 500mg/250mg Tablet as it may cause increased dizziness and can also increase the risk of stomach bleeding. Oropyrin Plus 500mg/250mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Stop taking Oropyrin Plus 500mg/250mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Oropyrin Plus 500mg/250mg Tablet unless prescribed. 

Drug-Drug Interactions: Oropyrin Plus 500mg/250mg Tablet may interact with antacids (ranitidine), hypnotics (zolpidem), anti-depressant (duloxetine, escitalopram), antihistamines (diphenhydramine, cetirizine), anti-convulsant (pregabalin, topiramate), anti-hypertensive (metoprolol), pain killers (hydrocodone), anti-anxiety (alprazolam), opioid pain or cough relievers  (codeine, hydrocodone),  other muscle relaxants (carisoprodol, cyclobenzaprine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have heart, kidney or liver dysfunction.

• RANITIDINE
• ZOLPIDEM
• DULOXETINE
• ESCITALOPRAM
• DIPHENHYDRAMINE
• CETIRIZINE
• PREGABALIN
• TOPIRAMATE
• METOPROLOL
• HYDROCODONE
• ALPRAZOLAM

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

• Performing yoga may also help in improving joint flexibility and pain management.

• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

• Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

• Acupuncture, massage and physical therapy may also be helpful.

• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

• Avoid smoking and alcohol consumption.

• Oropyrin Plus 500mg/250mg Tablet may rarely cause your urine to turn orange or reddish-purple. This effect is harmless and will disappear when the medication is stopped.
• Regular monitoring of liver function in patients with liver impairment is advised.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute or chronic and can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, soreness, and cracking or popping sounds at the joints.