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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Oradem 100 Tablet is used to treat depression, anxiety, and agitation. It contains Amoxapine, a second-generation tricyclic dibenzoxazepine antidepressant. It works by increasing the level of certain chemicals (GABA) in the brain that are responsible for mental health and mood changes. This medicine helps improve mood and feelings.

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Composition :

AMOXAPINE-100MG

Manufacturer/Marketer :

Ryon Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Oradem 100 Tablet

Oradem 100 Tablet is a second-generation tricyclic dibenzoxazepine antidepressant. It is used in the treatment of depression along with anxiety and agitation. Depression is a common but serious medical condition with a low/sad mood and lack of interest in daily activities. This condition negatively affects the person's feelings, thinking and how they act. Anxiety is a mental condition characterized by excessive fear or worry affecting an individual's daily activities. This medicine is mostly given when patients become intolerant to other antidepressants.

Oradem 100 Tablet contains Amoxapine, which is a second-generation tricyclic dibenzoxazepine antidepressant. It works by increasing the level of certain chemicals (GABA) in the brain that are responsible for your mental health and mood changes. This medicine helps make your mood good and feel better.

Oradem 100 Tablet may cause certain common side effects such as drowsiness, dry mouth, increased heart rate, constipation, dizziness, difficulty in urination, headache, fatigue, weakness, excessive appetite, restlessness, nervousness, confusion, and sudden blood pressure lowering on standing up (orthostatic hypotension). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Take Oradem 100 Tablet as prescribed by your doctor. Your doctor will decide the dose of the medicine based on the severity of the condition.

Avoid taking Oradem 100 Tablet if you are allergic to it or any of its ingredients. Oradem 100 Tablet is contraindicated in patients suffering from angle closure glaucoma (increased eye pressure), severe liver or kidney problems, asthma, difficulty in urination, bipolar disorder, neuroleptic malignant syndrome, tardive dyskinesia, and if taking monoamine oxidase inhibitors (MAOs). Let your doctor know about your entire medical history beforehand. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding before starting treatment with Oradem 100 Tablet. Do not stop taking Oradem 100 Tablet suddenly, as it can cause withdrawal symptoms like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. This medicine is not recommended for use in children below 16 years of age as the safety and efficacy are not established.

Uses of Oradem 100 Tablet

Treatment of Depression

Directions for Use

Take Oradem 100 Tablet as advised by the doctor. It can be taken with or without food. Swallow it as a whole with a glass of water. Do not crush, chew or break the medicine.

Medicinal Benefits

Oradem 100 Tablet contains Amoxapine which is a second-generation tricyclic dibenzoxazepine antidepressant. It works by increasing the level of certain chemicals (GABA) in the brain that are responsible for your mental health and mood changes. This medicine helps make your mood good and feel better. Oradem 100 Tablet helps treat depression when patients become intolerant to other medicines.

How Oradem 100 Tablet Works

Oradem 100 Tablet contains Amoxapine, which is a second-generation tricyclic dibenzoxazepine antidepressant. It works by increasing the level of certain chemicals (GABA) in the brain that are responsible for your mental health and mood changes. This medicine helps make your mood good and feel better.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Oradem 100 Tablet

  • Drowsiness
  • Dry mouth
  • Increased heart rate
  • Constipation
  • Difficulty in urination
  • Dizziness
  • Headache
  • Fatigue
  • Weakness
  • Excessive appetite
  • Restlessness
  • Nervousness
  • Confusion
  • Orthostatic hypotension (Sudden lowering of blood pressure on standing up)

What if I have taken an overdose of Oradem 100 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Oradem 100 Tablet may include change in consciousness, drowsiness, epileptic seizure (that will not stop), fatigue, high blood pressure, increased thirst, loss of consciousness, swelling of face, fingers, or lower legs, total body jerking, troubled breathing, and weight gain. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Oradem 100 Tablet should be avoided if you are allergic to it or any of its ingredients. Oradem 100 Tablet is contraindicated in patients suffering from angle closure glaucoma (increased eye pressure), severe liver or kidney problems, asthma, difficulty in urination, bipolar disorder, neuroleptic malignant syndrome, tardive dyskinesia, and if taking monoamine oxidase inhibitors (MAOIs). Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before starting treatment with Oradem 100 Tablet. Let your doctor know if you have liver or kidney disease, asthma, seizures, Parkinson’s disease, and high blood pressure before starting treatment with this medicine, as it may cause serious side effects. It is advised not to stop taking Oradem 100 Tablet suddenly as it can cause withdrawal symptoms like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. This medicine is not recommended for use in children below 16 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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AmoxapineTranylcypromine
Critical
AmoxapineMetoclopramide
Critical

Drug-Drug Interactions

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AmoxapineTranylcypromine
Critical
How does the drug interact with Oradem 100 Tablet:
Taking tranylcypromine with Oradem 100 Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Oradem 100 Tablet with Tranylcypromine is not recommended, but can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
AmoxapineMetoclopramide
Critical
How does the drug interact with Oradem 100 Tablet:
Co-administration of Metoclopramide with Oradem 100 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Oradem 100 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmoxapineZiprasidone
Critical
How does the drug interact with Oradem 100 Tablet:
Co-administration of Oradem 100 Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Ziprasidone and Oradem 100 Tablet but can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
AmoxapineSafinamide
Critical
How does the drug interact with Oradem 100 Tablet:
Taking Safinamide with Oradem 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Oradem 100 Tablet is not recommended, as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
AmoxapineSumatriptan
Severe
How does the drug interact with Oradem 100 Tablet:
Although it is a rare adverse effect, Coadministration of Sumatriptan and Oradem 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Sumatriptan and Oradem 100 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
AmoxapineDesvenlafaxine
Severe
How does the drug interact with Oradem 100 Tablet:
The combined use of Oradem 100 Tablet and Desvenlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Oradem 100 Tablet and Desvenlafaxine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, Increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
AmoxapineClonidine
Severe
How does the drug interact with Oradem 100 Tablet:
Co-administration of Clonidine and Oradem 100 Tablet may increase the risk and severity of increased blood pressure.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Oradem 100 Tablet, you can take these medicines together if prescribed by a doctor. However, contact a doctor if you experience sweating, nausea, vomiting, dizziness, flushing, stiff neck, headache, or heart palpitations. Do not discontinue the medication without consulting a doctor.
AmoxapineZonisamide
Severe
How does the drug interact with Oradem 100 Tablet:
Coadministration of Oradem 100 Tablet with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Oradem 100 Tablet with Zonisamide together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
AmoxapineParoxetine
Severe
How does the drug interact with Oradem 100 Tablet:
Coadministration of Oradem 100 Tablet with Paroxetine can cause sedation(excessive sleepiness).

How to manage the interaction:
Although there is an interaction between Paroxetine and Oradem 100 Tablet, it can be taken if prescribed by a doctor. However, if you experience confusion, poor muscle coordination, abdominal cramping, shivering, sweating, and high heart rate contact your doctor immediately. Do not stop using any medications without talking to a doctor.
AmoxapineEphedrine
Severe
How does the drug interact with Oradem 100 Tablet:
Co-administration of Amitriptyline with Ephedrine can enhance the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Ephedrine and Oradem 100 Tablet, you can take these medicines together if prescribed by a doctor. It's important to maintain your blood pressure. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to do regular exercise, which can help lower anxiety and improve your sleep and self-image.
  • Find humour in your daily life. Try to watch a comedy show to help relieve stress.
  • You can try increasing your mindfulness by including yoga, meditation, cognitive therapy, and mindfulness-based stress reduction.
  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve anxiety.
  • Include your diet with whole grains, vegetables, and fruits which is a healthier option than eating many simple carbohydrates in processed foods.
  • Include herbs like turmeric, ginger, and chamomile in the meal. It can reduce inflammation caused due to anxiety disorder.
  • Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Oradem 100 Tablet Substitute

Substitutes safety advice
  • Kamipox 100mg Tablet 10's

    14.63per tablet
  • Amilife 100 mg Tablet 10's

    13.05per tablet
  • Demolox 100mg Tablet

    7.30per tablet
  • Axa 100 Tablet

    14.40per tablet
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Alcohol

Unsafe

Alcohol should be avoided while on treatment with Oradem 100 Tablet as it can affect you much more and may make you feel more depressed.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy inform your doctor before taking Oradem 100 Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are breastfeeding, inform your doctor before receiving Oradem 100 Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Oradem 100 Tablet may cause drowsiness and impair your concentration. Hence, it is advised not to drive or operate machines while on treatment with Oradem 100 Tablet.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before taking Oradem 100 Tablet. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Oradem 100 Tablet. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Oradem 100 Tablet is not recommended for use in children below 16 years of age as the safety and efficacy are not established.

FAQs

Oradem 100 Tablet is used to treat Depression.
Oradem 100 Tablet contains Amoxapine, which belongs to the tricyclic antidepressant class of medicine. It works by increasing the level of certain chemicals (GABA) in the brain that are responsible for your mental health and mood changes.
It is always advised to take Oradem 100 Tablet around the same time every day for better results. Do not take more than the prescribed dose.
No, it is advised not to stop taking Oradem 100 Tablet suddenly as it can cause withdrawal symptoms like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. So, please consult your doctor; the doctor might lower your dose depending on your medical condition.
Oradem 100 Tablet may cause side effects such as drowsiness, dry mouth, constipation, dizziness, difficulty in urination, headache, fatigue, weakness, excessive appetite, restlessness, nervousness, confusion, and orthostatic hypotension (sudden lowering of blood pressure on standing up ). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
It is not known how/if Oradem 100 Tablet affects pregnancy or the newborn baby. Therefore, consult the doctor if you are pregnant, planning pregnancy or breastfeeding. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Oradem 100 Tablet may increase the risk of suicidal behaviour and thinking; hence, patients taking Oradem 100 Tablet should be monitored for clinical worsening, suicidality, or unusual changes in behaviour. Oradem 100 Tablet may cause drowsiness and impair your concentration. Hence, it is advised not to drive or operate machines while on treatment with Oradem 100 Tablet. Alcohol should be avoided while on treatment with Oradem 100 Tablet as it may cause increased drowsiness.

Country of origin

India
Other Info - ORAD134

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