Onerab-IV 20 mg Injection is used to treat gastric/duodenal ulcers, gastro-oesophageal reflux disease (GERD), heartburn, prevention of acid-aspiration, stress-induced mucosal injury, and Zollinger-Ellison syndrome.

Onerab-IV 20 mg Injection contains 'Rabeprazole' that works by blocking the action of the enzyme known as gastric proton pump, which is responsible for the production of acid. This helps in reducing the amount of acid produced, heals the ulcers and prevents the formation of new ulcers.

In some cases, you may experience certain common side effects, such as pain at the site of injection, diarrhoea, dizziness, dry mouth, headache, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

On long-term treatment, Onerab-IV 20 mg Injection may cause low magnesium levels and vitamin B12 levels and increase the risk of bone fractures. Consult your doctor if you are pregnant or breastfeeding. Onerab-IV 20 mg Injection may cause dizziness, so drive only if you are alert. Onerab-IV 20 mg Injection is not recommended for children as safety has not been established. Avoid consuming alcohol along with Onerab-IV 20 mg Injection as it could lead to increased drowsiness and can elevate the production of stomach acid.

Onerab-IV 20 mg Injection belongs to a group of antiulcer medicines called proton pump inhibitors. Onerab-IV 20 mg Injection is used to treat gastric ulcers, duodenal ulcers, gastro-oesophageal reflux disease (GERD), heartburn, prevention of acid-aspiration, stress-induced mucosal injury, and Zollinger-Ellison syndrome. Onerab-IV 20 mg Injection works by blocking the action of the enzyme known as gastric proton pump, which is responsible for the production of acid. This helps in reducing the amount of acid produced, heals the ulcers and prevents the formation of new ulcers.

• Pain at the site of injection
• Diarrhoea
• Dry mouth
• Dizziness
• Headache
• Abdominal pain

Do not take Onerab-IV 20 mg Injection if you are allergic to any of its contents. Inform your doctor if you have a stomach tumour, liver disease, or if you are due to have Chromogranin A blood test. On long-term treatment, Onerab-IV 20 mg Injection may cause low magnesium levels, vitamin B12 levels, and increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor before starting Onerab-IV 20 mg Injection if you are pregnant or breastfeeding. Onerab-IV 20 mg Injection may cause dizziness, so drive only if you are alert. Onerab-IV 20 mg Injection is not recommended for children as safety has not been established. Avoid consuming alcohol along with Onerab-IV 20 mg Injection as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Drug-Drug Interactions: Onerab-IV 20 mg Injection may have interaction with an anti-retroviral agent (atazanavir), anti-fungal (ketoconazole, itraconazole), anti-rheumatic (methotrexate).

Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

Drug-Disease Interactions: Inform your doctor if you have Clostridium difficile-associated diarrhoea, liver disease, bone fractures, and hypomagnesemia (low levels of magnesium).

• ATAZANAVIR
• KETOCONAZOLE
• ITRACONAZOLE
• METHOTREXATE

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating to prevent acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practise relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

• Inform your doctor before taking Onerab-IV 20 mg Injection if you are due to have Chromogranin A blood test.
• Onerab-IV 20 mg Injection may cause abnormal blood and liver enzyme values. Inform the person doing the tests that you are taking Onerab-IV 20 mg Injection.
• Onerab-IV 20 mg Injection may increase the risk of infections. Consult your doctor if you notice any signs or symptoms of infections.

Acidity: The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like acidity, GERD, heartburn, peptic ulcer, and Zollinger-Ellison syndrome.

Gastroesophageal reflux disease (GERD): It is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn.

Gastric/duodenal ulcer: It is a painful condition followed by the development of sores or ulcers in the duodenum or stomach lining.

Zollinger Ellison syndrome: It is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production, leading to peptic ulcers.