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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:20 PM IST

Omen Trio 40/12.5 Tablet is used to treat hypertension (high blood pressure). It works by relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. It reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Also, it removes extra water and certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. In some cases, it may cause side effects such as headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer

Medley Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Omen Trio 40/12.5 Tablet

Omen Trio 40/12.5 Tablet belongs to the class of medicines called hypertensives primarily used to treat hypertension (high blood pressure). Hypertension or high blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it leads to heart diseases, irregular heartbeat, and other complications.

Omen Trio 40/12.5 Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water, certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Take Omen Trio 40/12.5 Tablet with food or as advised by the doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on the dose and duration based on your medical condition. You may experience headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Omen Trio 40/12.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase the risk of getting stroke and heart diseases. Omen Trio 40/12.5 Tablet should be taken with caution in patients with chest pain (angina), kidney disease, heart failure, low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart). If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Omen Trio 40/12.5 Tablet can be prescribed accordingly. Do not use Omen Trio 40/12.5 Tablet if you cannot urinate,  are dehydrated, and increase fluid intake. Please inform your doctor if you are taking any other medicines or are allergic to this medicine. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Omen Trio 40/12.5 Tablet

Treatment of Hypertension (high blood pressure)

Medicinal Benefits

Omen Trio 40/12.5 Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Clindipine, and Chlorthalidone, which together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. Chlorthalidone is a diuretic that removes extra water, certain electrolytes from the body and efficiently reduces blood pressure.

Directions for Use

Omen Trio 40/12.5 Tablet should be taken daily with food to allow its slow absorption and reduce the risk of sudden lowering of blood pressure. Swallow the whole tablet with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Omen Trio 40/12.5 Tablet

  • Dizziness
  • Headache
  • Peripheral oedema (swelling of legs/hands)
  • Flushing (skin reddening)
  • Rash
  • Taste change
  • Upset stomach

Drug Warnings

Omen Trio 40/12.5 Tablet should not be given to the people allergic to Omen Trio 40/12.5 Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Omen Trio 40/12.5 Tablet can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking Omen Trio 40/12.5 Tablet and breastfeeding. Grapefruit juice and St. John's wort plant should not be consumed when taking Omen Trio 40/12.5 Tablet as it is contraindicated. Omen Trio 40/12.5 Tablet contain hydrochlorothiazide which can cause hypokalaemia (low potassium), hyponatremia (low sodium) and hypomagnesemia (low magnesium). So regular monitoring of electrolytes is required while taking treatment with Omen Trio 40/12.5 Tablet. Do not take Omen Trio 40/12.5 Tablet if you have low or no urine output, are allergic to other sulfonamide antibiotics, or are taking Aliskiren and have diabetes. Drinking alcohol while using Omen Trio 40/12.5 Tablet can cause you to have low blood pressure, so avoid intake of alcoholic beverages.

Drug Interactions

Drug-Drug Interaction: Omen Trio 40/12.5 Tablet may interact with other high blood pressure-lowering pills (benazepril, metoprolol, ramipril, hydrochlorothiazide, simvastatin, diltiazem, aliskiren, verapamil, azilsartan, benazepril, lisinopril, amiloride), and can lower your blood pressure leading to severe condition. Besides this, medicine to treat erectile dysfunction (sildenafil), antibiotics (clarithromycin, erythromycin), anti TB drug (rifampicin), antifungal (itraconazole, ketoconazole), anti-HIV drugs (ritonavir), anti-epilepsy medicines (carbamazepine, phenytoin, phenobarbital, primidone), antibiotics (erythromycin), immune-suppressing drugs (cyclosporine, tacrolimus), and pain killers (ibuprofen, aspirin) should not be taken with Omen Trio 40/12.5 Tablet.

Drug-Food Interaction: Omen Trio 40/12.5 Tablet severely interacts with grapefruit, grapefruit juices, and St. John’s wort (a plant used to treat depression). Hence it should not be taken with Omen Trio 40/12.5 Tablet.

Drug-Disease Interaction: Omen Trio 40/12.5 Tablet should not be given to the people with electrolytes problem (low potassium, low magnesium or low sodium), chest pain (angina), cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problem (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, kidney problem, or heart failure.

Drug-Drug Interactions Checker List

  • SILDENAFIL
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • RIFAMPICIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • PRIMIDONE
  • TACROLIMUS
  • IBUPROFEN
  • ASPIRIN
  • ALISKIREN
  • SIMVASTATIN
  • HYDROCHLOROTHIAZIDE
  • METOPROLOL
  • RAMIPRIL

Habit Forming

No

Diet & Lifestyle Advise

  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week, can help lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products. 
  • Limit your intake of sodium chloride (table salt) to 2300 mg per day, or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, then only one serving for women and two servings is advisable. 
  • Quitting smoking is the best strategy to lower the risk of heart disease. 
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques. 
  • Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Special Advise

Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor. 

Disease/Condition Glossary

High blood pressure: It is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.

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Alcohol

Unsafe

Omen Trio 40/12.5 Tablet can lower your blood pressure, causing dizziness and drowsiness. It can also cause orthostatic hypotension (a sudden fall in blood pressure while standing). So try to avoid taking Omen Trio 40/12.5 Tablet with alcoholic beverages.

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Pregnancy

Unsafe

Omen Trio 40/12.5 Tablet is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Omen Trio 40/12.5 Tablet as soon as possible and consult the doctor.

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Breast Feeding

Caution

Omen Trio 40/12.5 Tablet passes into the breast milk, but its effect on the baby is not clear. Therefore, it is advisable to contact the doctor before intake of Omen Trio 40/12.5 Tablet.

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Driving

Unsafe

Omen Trio 40/12.5 Tablet may cause side effects, which could affect your ability to drive. Taking Omen Trio 40/12.5 Tablet may lower your blood pressure.

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Liver

Caution

Omen Trio 40/12.5 Tablet to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Not recommended in patients with chronic kidney disease (severe renal impairment). Safety and effectiveness in patients with severe renal impairment have not been established.

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Children

Unsafe

Omen Trio 40/12.5 Tablet is not recommended in children. The safety and efficacy of Omen Trio 40/12.5 Tablet in children have not yet been established.

Country of origin

India
Other Info - OM46314

Author Details

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FAQs

Omen Trio 40/12.5 Tablet is used to treat high blood pressure. It works by relaxing blood vessels, reducing the heart's workload and making the heart more efficient at pumping blood throughout the body. It also removes extra water and certain electrolytes from the body and efficiently reduces blood pressure.
It is advised to continue your medicine even after your blood pressure is under control or becomes normal as blood pressure can shoot up at any time. If you have a persistent headache, please consult your doctor immediately.
Yes, Omen Trio 40/12.5 Tablet is contraindicated in people with known allergy to any of this medicine's components. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.
Yes, Omen Trio 40/12.5 Tablet can cause dry mouth. Therefore, it is always advised to increase fluid intake while taking Omen Trio 40/12.5 Tablet. If you still feel excessively thirsty, please consult your doctor and advise for the best results of Omen Trio 40/12.5 Tablet.
It is unlikely that Omen Trio 40/12.5 Tablet affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There is not enough evidence to say for certain. For the best advice, consult your doctor.
Yes, Omen Trio 40/12.5 Tablet is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists, consult your doctor and do what is advised.
Yes, Omen Trio 40/12.5 Tablet can cause an upset stomach. So, it is preferred to take Omen Trio 40/12.5 Tablet with food to avoid it.
High blood pressure during pregnancy may cause eclampsia, which can be harmful to both baby and mother. Therefore, during pregnancy, you should have regular blood pressure monitoring.
Omen Trio 40/12.5 Tablet, if stopped abruptly, can lead to withdrawal symptoms. So, before stopping Omen Trio 40/12.5 Tablet, consult your doctor; your dose will be lowered gradually to avoid unpleasant side effects of Omen Trio 40/12.5 Tablet.
Omen Trio 40/12.5 Tablet and Cilacar 10 are medications used to treat high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Omen Trio 40/12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Cilacar 10 contains Cilnidipine.
Omen Trio 40/12.5 Tablet and Benlong 4 mg are medications used to treat high blood pressure (hypertension). Still, they differ in their active ingredients and mechanism of action. Omen Trio 40/12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Benlong 4 mg contains Benidipine.
Omen Trio 40/12.5 Tablet and Telma 40 are medications for treating high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Omen Trio 40/12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Telma 40 contains Telmisartan.
Omen Trio 40/12.5 Tablet and Ciplar tablet differ in their composition and mechanism of action. Omen Trio 40/12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone, while the Ciplar tablet contains Propranolol.
Omen Trio 40/12.5 Tablet is a combination of three medicines, namely Olmesartan medoxomil, Cilnidipine, and Chlorthalidone, which help lower raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the heart's blood vessels. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water and certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.
Common side effects of Omen Trio 40/12.5 Tablet may include headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Omen Trio 40/12.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Omen Trio 40/12.5 Tablet can start showing its effect within one hour of its oral intake. However, it may take a few days to show its full effect, and this may vary from person to person.
Yes, Omen Trio 40/12.5 Tablet can generally be taken on an empty stomach. However, it's always best to follow your doctor's instructions or as mentioned on the medication label.
No, you should not take Omen Trio 40/12.5 Tablet or any other prescription medication on your own. Omen Trio 40/12.5 Tablet is a prescription medication used to treat high blood pressure. Consult with a healthcare professional before starting any new medication, including Omen Trio 40/12.5 Tablet, is essential. They can diagnose your condition accurately and prescribe the correct dosage.
No, you should not drink alcohol while taking this medication. Alcohol can increase the risk of side effects, such as dizziness and lightheadedness.
No, you should not drink grapefruit juice while taking this medication. Grapefruit juice can interact with this medication and increase the risk of side effects.
Omen Trio 40/12.5 Tablet may interact with certain medications. So, you should talk to your doctor before taking any over-the-counter medications, such as pain relievers or cold medications, while taking this medication.
Your doctor will monitor your blood pressure to evaluate if this medicine is effective. You may also experience less symptoms, such as headaches or dizziness.
The long-term effects of taking this medicine remain unclear. However, the majority of people who use this drug do not encounter any serious long-term negative effects.
Omen Trio 40/12.5 Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.
Omen Trio 40/12.5 Tablet is not recommended in children. The safety and efficacy of Omen Trio 40/12.5 Tablet in children have not yet been established.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Omen Trio 40/12.5 Tablet is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Omen Trio 40/12.5 Tablet as soon as possible and consult the doctor.

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