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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Olumiant 4 mg Tablet belongs to the class of immunomodulators used in the treatment of rheumatoid arthritis, atopic dermatitis and coronavirus infection. This medicine works by stopping the viral entry into body cells, limits viral replication, and thereby controls the release of cytokines. Common side effects include throat infection, fatigue and high blood cholesterol.

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Composition :

BARICITINIB-4MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Olumiant 4 mg Tablet

Olumiant 4 mg Tablet belongs to the group of immunomodulators. Olumiant 4 mg Tablet is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis. Rheumatoid arthritis is a chronic inflammatory and autoimmune disorder of the joints. Atopic dermatitis is a skin disease in which the skin becomes red, inflamed and itchy.  Coronavirus disease is an infectious disease caused by SARS-CoV-2. It can range from a mild cold to a serious form of pneumonia

Olumiant 4 mg Tablet contains ‘’Baricitinib.’’ Olumiant 4 mg Tablet works by inhibiting viral entry into body cells, limits viral replication and also controls the release of inflammatory mediators called cytokines.

Take Olumiant 4 mg Tablet as prescribed by the doctor. Olumiant 4 mg Tablet may cause certain common side effects such as throat infection, fatigue and high blood cholesterol. Most of these adverse effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to Olumiant 4 mg Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Olumiant 4 mg Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, painkillers, steroids and/or drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Olumiant 4 mg Tablet use with alcohol.

Uses of Olumiant 4 mg Tablet

Treatment of Rheumatoid Arthritis, Atopic Dermatitis and COVID-19

Directions for Use

Take Olumiant 4 mg Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Olumiant 4 mg Tablet is an immunomodulator used in the treatment of various types of cancers and infections such as Covid-19. Olumiant 4 mg Tablet contains Baricitinib. Baricitinib works by inhibiting the entry of the virus into the body cells. Olumiant 4 mg Tablet targets an enzyme called Janus kinase (JAK-2), which is responsible for the formation of cytokines. Cytokines are inflammatory mediators. Hence, by inhibiting a cytokine-forming enzyme, Baricitinib reduces the level of cytokines in the body, thus relieving signs of inflammation.  In addition, Baricitinib works by reducing viral replication, thus arresting the progress of the disease.

How Olumiant 4 mg Tablet Works

Olumiant 4 mg Tablet contains ‘’Baricitinib.’’ Olumiant 4 mg Tablet works by inhibiting viral entry into body cells, limits viral replication and also controls the release of inflammatory mediators called cytokines.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Olumiant 4 mg Tablet

  • Throat infections

  • High blood cholesterol

  • Cold sores

  • Rash

  • Acne

What if I have taken an overdose of Olumiant 4 mg Tablet

Never take more than the prescribed dose of Olumiant 4 mg Tablet as it may lead to serious side effects. Patients should promptly seek medical attention and be closely monitored for signs and symptoms of adverse reactions in the event of an overdose. Since there is no known counteragent for Baricitinib, patients ought to receive supportive care.

Drug Warnings

It is advisable to inform the doctor if you are allergic to Olumiant 4 mg Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Olumiant 4 mg Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, DMARD’s, painkillers, steroids and/or any drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Olumiant 4 mg Tablet use with alcohol.

Drug-Drug Interactions

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BaricitinibCiclosporin
Critical
BaricitinibAzathioprine
Severe

Drug-Drug Interactions

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BaricitinibCiclosporin
Critical
How does the drug interact with Olumiant 4 mg Tablet:
Co-administration of Olumiant 4 mg Tablet with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Ciclosporin with Olumiant 4 mg Tablet is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibAzathioprine
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Olumiant 4 mg Tablet and azathioprine can raise the risk of developing harmful infections.

How to manage the interaction:
Although there is an interaction, Olumiant 4 mg Tablet can be taken with azathioprine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibLinezolid
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of linezolid and Olumiant 4 mg Tablet may raise the risk of serious infections.

How to manage the interaction:
Although taking linezolid and Olumiant 4 mg Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
BaricitinibTocilizumab
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Tocilizumab with Olumiant 4 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Tocilizumab with Olumiant 4 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
BaricitinibCladribine
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Olumiant 4 mg Tablet and cladribine can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 4 mg Tablet can be taken with cladribine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibPrednisone
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Using Olumiant 4 mg Tablet together with prednisone may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 4 mg Tablet can be taken with prednisone if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, severe stomach pain, nausea, vomiting, consult a doctor. Do not stop using any medications without talking to a doctor.
BaricitinibUstekinumab
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Taking Olumiant 4 mg Tablet with Ustekinumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Olumiant 4 mg Tablet and Ustekinumab, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
BaricitinibEtoposide
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Olumiant 4 mg Tablet and etoposide can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 4 mg Tablet can be taken with etoposide if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibVincristine
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Vincristine with Olumiant 4 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Olumiant 4 mg Tablet and Vincristine together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
BaricitinibEribulin
Severe
How does the drug interact with Olumiant 4 mg Tablet:
Coadministration of Eribulin with Olumiant 4 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Taking Olumiant 4 mg Tablet with Eribulin together can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Coadministration of Olumiant 4 mg Tablet and high-fat meals can decrease the absorption of Olumiant 4 mg Tablet. Avoid fatty food and oily food while being treated with Olumiant 4 mg Tablet.

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is the one of the biggest causes of decreased immunity. See a therapist if you feel the need. 

  • Meditation, music and yoga have also proven very effective in helping with mental health.

  • Keep yourself at a safe distance from people.

  • Always sneeze or cough into your elbow and keep a handkerchief on you.

  • Wash your hands with soap and water and keep yourself clean.

  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.

  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.

  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 

  • Avoid taking Olumiant 4 mg Tablet with alcohol as there may be an interaction.

  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.

  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. Doing weight-bearing exercises can prove very helpful in promoting bone health.

  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.

  • Spend time under the sun (however with proper sunscreen) for quality intake of Vitamin D. Vitamin D is necessary for the absorption of Calcium, which is the most important component of bones and can help with bone and joint pain.

Habit Forming

No

Therapeutic Class

IMMUNOMODULATORS

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Alcohol

Caution

It is not recommended to use alcohol with Olumiant 4 mg Tablet. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Olumiant 4 mg Tablet is absolutely contraindicated during pregnancy.

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Breast Feeding

Caution

Not enough studies exist to ascertain the effect of Olumiant 4 mg Tablet on nursing. Olumiant 4 mg Tablet is not recommended to use without contraception during and for at least 1 week after treatment. Please consult your doctor in case of any concerns.

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Driving

Safe if prescribed

Olumiant 4 mg Tablet does not affect your ability to drive.

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Liver

Caution

Exercise caution before using Olumiant 4 mg Tablet in case of established liver disease as it may cause a derangement of liver enzymes. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Olumiant 4 mg Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Caution

Not enough studies exist to ascertain the effect of Olumiant 4 mg Tablet in children. Please consult your doctor in case of any concerns.

FAQs

Olumiant 4 mg Tablet belongs to the group of immunomodulators. It is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis.

Olumiant 4 mg Tablet works by preventing the virus from attaching to the body’s cell receptors and thereby blocking its entry and spread.

If you suffer from Chronic Kidney Disease, please consult with your doctor before using Olumiant 4 mg Tablet and discuss any concerns with them. Olumiant 4 mg Tablet is to be used with caution in those suffering from kidney and liver problems.

Not enough literature exists to ascertain the effects of Olumiant 4 mg Tablet on fertility. However, Olumiant 4 mg Tablet should be absolutely avoided in pregnancy. Please consult your doctor in case of any concerns.

Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are some risk factors for disease progression.

If you have liver problems, you should consult a healthcare practitioner before using Baricitinib. Baricitinib may impair liver function, so your doctor will need to analyze your specific circumstances to determine whether the benefits exceed risk.

While Olumiant 4 mg Tablet has not been directly related to cancer, you should discuss any potential concerns with your doctor. They can give you with information based on the most recent research and your individual health needs.

Before starting Olumiant 4 mg Tablet, your doctor may recommend certain investigations to assess your overall health and to monitor for any potential side effects. These may include blood tests, liver function tests, and other assessments as needed.

Country of origin

India

Manufacturer/Marketer address

Plot# 92, Sector 32, Institutional Area, Gurgaon-122001, Haryana, India
Other Info - OLU0002

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