Olsertain-H 40 Tablet belongs to a group of medications called 'anti-hypertensives' primarily used to treat high blood pressure (hypertension). High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Olsertain-H 40 Tablet is a combination of two medicines: Olmesartan medoximil and Hydrochlorothiazide. Olmesartan medoximil is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. On the other hand, Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Olsertain-H 40 Tablet lowers blood pressure and fluid overload.

You can take Olsertain-H 40 Tablet with food or without food with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, dizziness, and decreased blood pressure. Most of these side effects of Olsertain-H 40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless your doctor tells you. In rare cases, Olsertain-H 40 Tablet can cause a condition that results in a skeletal muscle problem, leading to further kidney failure. If you notice unexplained muscle pain, dark colour urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from kidney, liver, or heart disease or are diabetic. If you are pregnant or breastfeeding, do not take Olsertain-H 40 Tablet as it is a category D pregnancy drug and may harm the baby. Do not use Olsertain-H 40 Tablet if you cannot urinate, are dehydrated, have low blood pressure (hypotension), and have or have had cardiogenic shock (sudden stopping of blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine.

Olsertain-H 40 Tablet is primarily used to treat high blood pressure. Olsertain-H 40 Tablet is a combination of two medicines: Olmesartan and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). It is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin and relaxes blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. Hydrochlorothiazide (diuretic or water pill); removes extra water and certain electrolytes from the body. Together, both lower fluid overload, and blood pressure, improve blood flow and reduce the future risk of a heart attack.

• Stuffy nose/sore throat
• Nausea
• Upset stomach
• Headache
• High level of uric acid
• Diarrhoea
• Electrolyte imbalance
• Dehydration
• Dizziness
• Decreased blood pressure

Do not use Olsertain-H 40 Tablet if you are pregnant, planning for pregnancy, or unable to urinate (anuria). If you have diabetes and taking Olsertain-H 40 Tablet with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Olsertain-H 40 Tablet may pass into breast milk, so before starting Olsertain-H 40 Tablet , either you need to stop nursing, or you should not take Olsertain-H 40 Tablet while breastfeeding. Please inform your doctor before surgery if you are taking Olsertain-H 40 Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia. Avoid potassium salt or its substitute intake while using Olsertain-H 40 Tablet to avoid any electrolyte imbalance. 

Drug-Drug Interactions: This medicine may interact with an antidepressant (lithium), heart rhythm-controlling medicines (digoxin), blood thinner (aspirin), antidiabetic medicines (metformin, insulin), medicines used to treat erectile dysfunction (sildenafil), medicines used to lower cholesterol levels (simvastatin), immunosuppressants (cyclosporine), and other anti-hypertensive medicines (atenolol, aliskiren, enalapril, lisinopril, ramipril, metoprolol), pain killers (ibuprofen), medicines for treating stomach ulcers (carbenoxolone).

Drug-Food Interactions: Olsertain-H 40 Tablet may interact with high potassium-containing food and drinks. So, if you are using any of the OTC items, please tell your doctor. Also, alcohol should not be consumed while taking Olsertain-H 40 Tablet .

Drug-Disease Interactions: The efficacy of Olsertain-H 40 Tablet is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, low blood pressure, low potassium level, low electrolytes (sodium, potassium, calcium, etc.), anuria (non-passage of urine), angioedema (an allergic condition with swelling under the skin), lupus (an autoimmune disease), kidney disease, liver disease, asthma, diabetes.

• LITHIUM
• DIGOXIN
• ASPIRIN
• METFORMIN
• INSULIN
• SILDENAFIL
• SIMVASTATIN
• CYCLOSPORINE
• ATENOLOL
• ALISKIREN
• LISINOPRIL
• RAMIPRIL
• METOPROLOL
• IBUPROFEN
• CARBENOXOLONE

• Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.
• Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
• Use healthy cooking oils like soybean, olive, canola, and coconut oil.
• You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
• Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
• Avoid consumption of too much salt or salty food.
• Keep your weight under control with a BMI of 19.5-24.9.
• Regular physical activity or exercise like walking improves your blood flow.
• Avoid chronic stress, as it can raise your blood pressure.
• Spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force our heart uses to pump blood to all body parts. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.