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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Okagesic MR Tablet is used to reduce musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). It works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Also, it helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles. It may cause side effects such as drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Okagesic MR Tablet

Okagesic MR Tablet is used in the reduction of musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Pain can be temporary (acute) or long-term (chronic) in nature. Musculoskeletal pain can be caused due to soft tissue (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

Okagesic MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Okagesic MR Tablet can be taken with or after the meal. To avoid stomach upset Okagesic MR Tablet can be taken with food or milk. It should be swallowed whole with a glass of water. Do not take Okagesic MR Tablet if your pain lasts for more than ten days or if the fever lasts for more than three days. Do not take a double dose if you missed one dose. Like all medicines, Okagesic MR Tablet may cause side effects, although not everybody gets them. Most of the side effects of Okagesic MR Tablet are drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. In case of any discomfort, speak with your doctor. 

Do not take Okagesic MR Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Okagesic MR Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause even more side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation and fever do not disappear even after ten days.

Uses of Okagesic MR Tablet

Treatment of Musculoskeletal pain.

Directions for Use

Take Okagesic MR Tablet as advised by your doctor. Preferably take it with a light meal. Swallow it as a whole; do not chew or crush it.

Medicinal Benefits

Okagesic MR Tablet is composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

How Okagesic MR Tablet Works

Okagesic MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Okagesic MR Tablet

  • Drowsiness
  • Constipation
  • Diarrhoea
  • Stomach upset
  • Slight discolouration of urine
  • Ringing or buzzing sounds in the ears

What if I have taken an overdose of Okagesic MR Tablet

Do not take more than the prescribed dose of Okagesic MR Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Intake of Okagesic MR Tablet should be avoided in liver disease (like jaundice) and cardiovascular disease (like coronary heart disease). Contact your doctor if you have signs of liver disease like feeling exhausted, dark urine, not feeling hungry, stomach pain or upset, light coloured stools or yellow skin/eyes. After taking if you have possible allergic symptoms like difficulty in breathing, difficulty in swallowing, lips/face/throat swelling, chest tightness, or skin rash, contact the doctor immediately. Ensure your doctor is aware if you are pregnant or planning to get pregnant, breastfeeding, allergic to Okagesic MR Tablet or any other painkillers like aspirin, the problem of stomach ulcer or gastric bleeding, or taking any other OTC multivitamins, multi-minerals supplements.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
ParacetamolOxazepam
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Okagesic MR Tablet:
Co-administration of Okagesic MR Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Okagesic MR Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
ParacetamolOxazepam
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Okagesic MR Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Okagesic MR Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Okagesic MR Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Okagesic MR Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Mipomersen with Okagesic MR Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Okagesic MR Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Teriflunomide with Okagesic MR Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Okagesic MR Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Lomitapide and Okagesic MR Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Okagesic MR Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetamine
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of ketamine and Okagesic MR Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Okagesic MR Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Okagesic MR Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Okagesic MR Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration of Okagesic MR Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Okagesic MR Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
DiclofenacDalteparin
Severe
How does the drug interact with Okagesic MR Tablet:
Co-administration use of Okagesic MR Tablet with Dalteparin may increase the risk of bleeding complications.

How to manage the interaction:
Although taking Dalteparin with Okagesic MR Tablet may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Okagesic MR Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
  • Avoid driving while consuming Okagesic MR Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
  • Avoid concomitant consumption of drugs containing the same chemicals as Okagesic MR Tablet as it can lead to overdosage and unwanted side effects.
  • Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Okagesic MR Tablet.
  • Avoid consuming alcohol while you are on Okagesic MR Tablet.

Habit Forming

No

Therapeutic Class

ANALGESICS

Okagesic MR Tablet Substitute

Substitutes safety advice
  • VINZOX MR TABLET

    9.90per tablet
  • Dolentia-Relax Tablet 10's

    5.31per tablet
  • Inodox CV Dry Syrup

    3.63per tablet
  • Leporam MR 500mg/50mg/500mg Tablet

    7.83per tablet
  • Combinac-MR 500mg/50mg/500mg Tablet

    4.95per tablet
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Alcohol

Caution

Alcohol should not be consumed with Okagesic MR Tablet as it leads to excessive drowsiness

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Pregnancy

Caution

Only consume Okagesic MR Tablet, if you are prescribed by a doctor

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Breast Feeding

Caution

Okagesic MR Tablet does not pass on to the child significantly via breast milk, consult your doctor before using Okagesic MR Tablet.

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Driving

Caution

Okagesic MR Tablet may affect driving ability as it causes dizziness.

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Liver

Caution

Okagesic MR Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Okagesic MR Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Okagesic MR Tablet is not recommended for children below 12 years of age without doctor's consent. For children above 12 years, dose to be adjusted and recommended by a child specialist only.

FAQs

Okagesic MR Tablet is used to treat musculoskeletal pain due to tissue injury, post-surgery inflammation and oedema (swollen tissue with fluid).
No, Okagesic MR Tablet should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Okagesic MR Tablet, take it in doses and duration mentioned by your doctor.
No, it is not advisable to take Okagesic MR Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Okagesic MR Tablet.
Yes, Okagesic MR Tablet is a short term medication and if you feel better you can stop taking Okagesic MR Tablet, but only after consulting your doctor.
Okagesic MR Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.
No, Okagesic MR Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer or gastric bleeding. Do not take Okagesic MR Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.
It depends on whether your cough and cold pills contains diclofenac, paracetamol and Chlorzoxazone or not. If it contains these three medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.
No, do not take Okagesic MR Tablet until prescribed by your doctor. For example, your shoulder pain may be due to lungs, spleen or gallbladder problem. Your back pain may be due to kidney stone, pancreas swelling, or in women, pelvic disorders. Your arm pain (especially left arm) may be due to heart attack (myocardial infarction).
Okagesic MR Tablet is a combination of a muscle relaxant (Chlorzoxazone) and two pain relieving medicines (Diclofenac and Paracetamol).
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.
Okagesic MR Tablet is not intended to treat toothache. It is used to reduce musculoskeletal pain.
Avoid simultaneous consumption of other painkillers or cough and cold medicines with this Okagesic MR Tablet, as it may lead to an overdose.
No, it is not indicated to treat gastritis. It may worsen your condition.
It may help ease pain associated with period pain. However, it should only be used if recommended by the doctor.
It may help ease headaches. However, it should be used only if recommended by the doctor.
Okagesic MR Tablet usually takes effect within 30 minutes to an hour of intake.
No, it does not contain steroids. It combines one muscle relaxant medication and two pain relieving medicines.
Yes, in some cases, Okagesic MR Tablet may cause acidity.
Yes, Okagesic MR Tablet may cause drowsiness, although not everybody gets it. If you experience any discomfort, speak with your doctor.
No, Okagesic MR Tablet is not intended to treat loose motion. It is meant to treat musculoskeletal pain.
Yes, it can be used to treat tissue or ligament injury. However, it should be used only if recommended by a doctor.
Okagesic MR Tablet may cause constipation, although not everybody gets it. If you experience any discomfort, speak with your doctor.
Okagesic MR Tablet is safe if used as advised by the doctor. Follow your doctor's instructions.
It may cause common side effects like nausea and vomiting in some patients, although not everybody gets them. If you experience any discomfort, speak with your doctor.
Yes, it may lead to dizziness, although not everybody gets it. If you experience any discomfort, consult your doctor.
Yes, long-term usage of Okagesic MR Tablet may be harmful to the kidney.
Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children.
Yes, it should be taken with food or after food.
Okagesic MR Tablet should not be used during pregnancy and by nursing mothers unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Okagesic MR Tablet.
Okagesic MR Tablet is not recommended for children below 12 years of age without a doctor's consent. For children above 12 years, the dose is to be adjusted and recommended by a child specialist only.
Alcohol should not be consumed with Okagesic MR Tablet as it leads to excessive drowsiness.
Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Country of origin

India

Manufacturer/Marketer address

128/5, Swiss House, Vishwas Nagar, Delhi 110032 Delhi, India
Other Info - OK21228

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