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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:18 PM IST
Ocifril 75mg Tablet XR is used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). It contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain involved in regulating mood, behaviour and emotions. Thereby, relieves depression, lighten the mood and relieve anxiety symptoms such as fear and panic. It may cause side effects such as dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination.Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Consume Type

ORAL

Return Policy

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About Ocifril 75mg Tablet XR

Ocifril 75mg Tablet XR belongs to a class of drugs called 'antidepressants' used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). Depression is a mood disorder associated with symptoms such as sadness and the inability to sleep properly or enjoy life as you used to do. Panic or anxiety disorder is linked to anxiety with sudden feelings of unnecessary fear or worries even when there is no danger in reality.

Ocifril 75mg Tablet XR contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Ocifril 75mg Tablet XR helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Take Ocifril 75mg Tablet XR with food as prescribed by your doctor and swallow whole with a glass of water. Do not break, crush or chew it. Your doctor will advise you how often you take Ocifril 75mg Tablet XR based on your medical condition. Some people may experience dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination. Most of these side effects of Ocifril 75mg Tablet XR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Ocifril 75mg Tablet XR or any other medicines, please tell your doctor. Ocifril 75mg Tablet XR is not recommended for children below 17 years of age. Avoid taking Ocifril 75mg Tablet XR if you are pregnant, as it may cause harm to the foetus. Avoid breastfeeding while taking Ocifril 75mg Tablet XR as it may be excreted in human milk and cause adverse effects in the baby. If you have any self-harming or suicidal thoughts before taking Ocifril 75mg Tablet XR, inform your doctor as they may worsen in the initial days of taking Ocifril 75mg Tablet XR.

Uses of Ocifril 75mg Tablet XR

Treatment of Obsessive-compulsive disorder (OCD), Depression, Panic disorder, Anxiety disorder.

Medicinal Benefits

Ocifril 75mg Tablet XR contains Clomipramine, an antidepressant used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. Ocifril 75mg Tablet XR increases the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Ocifril 75mg Tablet XR helps in relieving depression, lightening the mood and relieving anxiety symptoms such as fear and panic. Ocifril 75mg Tablet XR, in combination with other medicines, may be used to treat cataplexy (a disorder that causes muscle weakness), which usually affects people suffering from narcolepsy (uncontrollable sleepiness during daytime).

Directions for Use

Take Ocifril 75mg Tablet XR with food or as advised by a doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ocifril 75mg Tablet XR

  • Dizziness
  • Headache
  • Drowsiness
  • Dry mouth
  • Nausea
  • Weight gain
  • Increased sweating
  • Constipation
  • Shaking
  • Blurred vision
  • Erectile dysfunction
  • Difficulty in urination

Drug Warnings

If you are allergic to Ocifril 75mg Tablet XR or any other medicines, please tell your doctor. Ocifril 75mg Tablet XR is not recommended for children below 17 years of age. Avoid taking Ocifril 75mg Tablet XR if you are pregnant as it may cause harm to the fetus. Avoid breastfeeding while taking Ocifril 75mg Tablet XR as Ocifril 75mg Tablet XR may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are pregnant, planning for pregnancy, or breastfeeding. Ocifril 75mg Tablet XR should be used with caution in elderly patients as there is an increased risk of low sodium levels in the blood.  If you have any self-harming or suicidal thoughts before taking Ocifril 75mg Tablet XR, inform your doctor as they may worsen in the initial days of taking Ocifril 75mg Tablet XR. Do not take Ocifril 75mg Tablet XR with monoamine oxidase inhibitors (MAOIs) such as moclobemide, tranylcypromine and phenelzine used to treat depression as it may cause severe adverse effects. Also, avoid taking Ocifril 75mg Tablet XR with buprenorphine as it may cause a serious life-threatening condition. If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumor of the adrenal gland), low potassium levels in blood, kidney, liver, or heart problems, inform your doctor before taking Ocifril 75mg Tablet XR.

Drug Interactions

Drug-Drug Interaction: Ocifril 75mg Tablet XR may have interaction with antiparkinson drugs (selegiline, levodopa), antibiotics (pentamidine, rifampicin), antipsychotic drugs (pimozide), opioid pain killers (buprenorphine, morphine, codeine), blood thinners (warfarin), monoamine oxidase inhibitors used to treat depression (moclobemide, phenelzine, tranylcypromine), antidepressants (fluoxetine, fluvoxamine, amitriptyline, sertraline, venlafaxine, dothiepin, maprotiline), antimanic drug (lithium), anticonvulsants  (phenytoin, carbamazepine, phenobarbital, valproate), painkillers (aspirin), antacids (cimetidine), water tablets (furosemide), anti-allergic drug (terfenadine), medicines used to treat high blood pressure (betanidine, reserpine, guanethidine, clonidine), heart-related medicines (isoprenaline, amiodarone, quinidine, disopyramide, procainamide, epinephrine, diltiazem, verapamil), HIV drugs (ritonavir, indinavir).

Drug-Food Interaction: Avoid grapefruit, grapefruit juice, and cranberry juice as they may interact with Ocifril 75mg Tablet XR and increase the levels of Ocifril 75mg Tablet XR in the body, leading to more adverse effects. Also, avoid intake of alcohol while taking Ocifril 75mg Tablet XR as it may increase side effects such as drowsiness, blurred vision, or confusion.

Drug-Disease Interaction: If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumour of the adrenal gland), low potassium levels in the blood, kidney, liver or heart problems, inform your doctor before taking Ocifril 75mg Tablet XR.

Drug-Drug Interactions Checker List

  • SELEGILINE
  • LEVODOPA
  • PENTAMIDINE
  • RIFAMPICIN
  • PIMOZIDE
  • BUPRENORPHINE
  • MORPHINE
  • CODEINE
  • WARFARIN
  • MOCLOBEMIDE
  • PHENELZINE
  • TRANYLCYPROMINE
  • FLUVOXAMINE
  • FLUOXETINE
  • AMITRIPTYLINE
  • SERTRALINE
  • VENLAFAXINE
  • DOTHIEPIN
  • LITHIUM
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • VALPROATE
  • ASPIRIN
  • CIMETIDINE
  • FUROSEMIDE
  • TERFENADINE
  • RESERPINE
  • GUANETHIDINE
  • CLONIDINE
  • ISOPRENALINE
  • AMIODARONE
  • QUINIDINE
  • DISOPYRAMIDE
  • PROCAINAMIDE
  • EPINEPHRINE
  • DILTIAZEM
  • VERAPAMIL
  • RITONAVIR
  • INDINAVIR
  • MAPROTILINE
  • BETANIDINE

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety. Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Regularly attend therapy sessions.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Avoid smoking and alcohol consumption.

Special Advise

  • Regular blood tests are recommended while taking Ocifril 75mg Tablet XR to monitor liver and heart functioning.

  • Regular dental check-ups are also advised while taking Ocifril 75mg Tablet XR as it may cause dry mouth, which may increase the risk of tooth decay.

Disease/Condition Glossary

Obsessive-compulsive disorder (OCD): It is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions) leading to repetitive behaviours (compulsions).

Depression: It is a mood disorder associated with symptoms such as sadness, inability to sleep properly, or enjoy life as you used to do. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

Panic disorder: It is linked to anxiety with sudden feelings of fear when there is no danger in reality.

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Alcohol

Unsafe

Avoid consumption of alcohol with Ocifril 75mg Tablet XR as it may increase the risk of adverse effects such as drowsiness, blurred vision, or confusion.

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Pregnancy

Unsafe

Ocifril 75mg Tablet XR is a Category C pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby. Therefore, please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Ocifril 75mg Tablet XR as Ocifril 75mg Tablet XR may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are a breastfeeding mother.

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Driving

Unsafe

Ocifril 75mg Tablet XR may cause dizziness, tiredness, confusion, difficulty in concentrating or blurred vision. Therefore, avoid driving if you experience any of these symptoms after taking Ocifril 75mg Tablet XR.

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Liver

Caution

Take Ocifril 75mg Tablet XR with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

If you have any concerns regarding the use of Ocifril 75mg Tablet XR in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Ocifril 75mg Tablet XR is not recommended for children below 17 years of age, as the safety and effectiveness were not established. Please consult a doctor before using Ocifril 75mg Tablet XR.

Country of origin

India
Other Info - OC17242

Author Details

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FAQs

Ocifril 75mg Tablet XR is used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder.
Ocifril 75mg Tablet XR contains Clomipramine that works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain that are involved in regulating mood, behavior, and emotions. Thereby, Ocifril 75mg Tablet XR helps in relieving depression, lighten the mood and relieve anxiety symptoms such as fear and panic.
Yes, Ocifril 75mg Tablet XR may be used to treat panic disorder by reducing fear. However, please consult a doctor before using Ocifril 75mg Tablet XR.
You are not recommended to take Ocifril 75mg Tablet XR with buprenorphine as co-administration of these medicines may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, fits, diarrhea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking Ocifril 75mg Tablet XR with other medicines.
Yes, Ocifril 75mg Tablet XR may cause self-harming or suicidal thoughts especially in patients aged less than 25 years or who have a history of self-harming thoughts. Therefore, please consult a doctor immediately if you experience any such thoughts while taking Ocifril 75mg Tablet XR.
Ocifril 75mg Tablet XR may cause impotence (inability to maintain an erection) in males and may decrease sexual desire (libido) in both men and women. However, if you experience any such problems while taking Ocifril 75mg Tablet XR, please consult a doctor immediately.
It takes about 2 weeks or longer usually for Ocifril 75mg Tablet XR to work. However, it is recommended to use Ocifril 75mg Tablet XR for as long as your doctor has prescribed it for you.
Yes, Ocifril 75mg Tablet XR may cause weight gain due to an increase in the appetite. Regular exercise and a healthy diet are recommended while taking Ocifril 75mg Tablet XR to maintain proper body weight. However, if you notice any major changes in weight, please consult a doctor.
Yes, Ocifril 75mg Tablet XR is safe if used as prescribed by your doctor. Do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects persist or worsen.
Ocifril 75mg Tablet XR may cause side effects such as drowsiness, dizziness, constipation, erectile dysfunction, difficulty in urination, and dry mouth. If these side effects persist or worsen, please consult your doctor.
If you take an overdose of Ocifril 75mg Tablet XR, you may experience symptoms such as irregular heartbeats, low blood pressure, fits, drowsiness, muscle stiffness, restlessness, sweating, shortness of breath, dilated pupil or a decrease or absence of urine production. Severe overdose may lead to coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
No, do not stop taking Ocifril 75mg Tablet XR without consulting your doctor as discontinuing suddenly may worsen your condition and also cause withdrawal symptoms such as vomiting, nausea, dizziness, headache, weakness, fever, sleep problems, and irritability. Therefore, take Ocifril 75mg Tablet XR for duration advised by your doctor for best results. If you any of these side effects are bothering you, contact your doctor.

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