Nusam 400 New Tablet is used to treat various medical conditions, including depression, reduce pain and swelling in the joints, and conditions such as osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.

Nusam 400 New Tablet contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. Nusam 400 New Tablet ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.

Take Nusam 400 New Tablet as recommended by your doctor. In some cases, you may experience common side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not discontinue Nusam 400 New Tablet without consulting your doctor. Consult the doctor if you are pregnant or breastfeeding. Nusam 400 New Tablet can be given to children with extreme caution if recommended by the doctor. Avoid consuming alcohol with Nusam 400 New Tablet as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side effects.

The Nusam 400 New Tablet contains Ademetionine, a naturally occurring substance in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. In liver disease, Nusam 400 New Tablet ensures sufficient glutathione levels in the liver to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. In depression, it affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. In osteoarthritis, It stimulates the production of cartilage parts, reduces the inflammatory mediator, and has painkilling properties. Nusam 400 New Tablet is also effective in treating liver disease during pregnancy, improving symptoms in fibromyalgia, treating nerve problems in people with AIDS, or sexual dysfunction in men with depression.

• Headache
• Dizziness
• Feeling anxious
• Vomiting
• Stomach upset
• Diarrhoea
• Constipation
• Insomnia (sleep problem)
• Increased sweating

Do not take Nusam 400 New Tablet if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, if the inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer. Inform your doctor if you have heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, or kidney and liver problems. Do not take Nusam 400 New Tablet if you are pregnant or breastfeeding unless advised by your doctor. Nusam 400 New Tablet can be given to children with caution if recommended by the doctor. Avoid consuming alcohol along with Nusam 400 New Tablet as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions: Nusam 400 New Tablet may have interaction with monoamine oxidase inhibitors (medicines used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, selegiline), an antidepressant (bupropion, duloxetine, fluoxetine, sertraline), antiparkinsons (levodopa), pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Nusam 400 New Tablet may interact with bipolar depression, Parkinson's disease, biliary obstruction and liver impairment, variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), and liver encephalopathy.

• MOCLOBEMIDE
• PHENELZINE
• IPRONIAZID
• ISOCARBOXAZID
• NIALAMIDE
• TRANYLCYPROMINE
• SELEGILINE
• BUPROPION
• DULOXETINE
• FLUOXETINE
• SERTRALINE
• LEVODOPA
• TRAMADOL
• TRAZODONE
• HYDROCODONE
• OXYCODONE
• ACETAMINOPHEN

Liver disease:

• Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
• Foods rich in vitamins B and C and calcium are good for the gallbladder.
• Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
• Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
• Avoid tobacco and alcohol consumption.

Depression:

• Maintaining a healthy diet and regular exercise helps improve overall health and boost self-esteem.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
• Avoid smoking and alcohol consumption.

Osteoarthritis:

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.

• Your doctor may advise a regular liver function test to monitor the liver's function and the treatment progress.
• Do not use Nusam 400 New Tablet if you have used an MAO inhibitor (antidepressant) in the past 14 days, as a dangerous drug interaction could occur.

Primary biliary cholangitis: Primary biliary cholangitis, formerly known as primary biliary cirrhosis, is an autoimmune disease caused by bile duct damage in the liver. Bile ducts are the small channels that carry the bile (digestive fluid) from the liver to the small intestine, where it breaks down fats and aids in its absorption. Biliary cirrhosis causes a build-up of bile in the liver, which leads to liver damage.

Depression: Depression is a mood disorder characterized by sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

Osteoarthritis: Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age. The older you are, the more likely you are to get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints, and ligament injuries.