Numrex SP 100mg/325mg/15mg Tablet belongs to the class of medications called ‘analgesics’ used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.

Numrex SP 100mg/325mg/15mg Tablet is a combination medicine that contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide and Paracetamol are pain killers. They can also reduce fever and inflammation. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. On the other hand, Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation and promotes healing.

Numrex SP 100mg/325mg/15mg Tablet is available in the form of a tablet. It would be best if you took this Numrex SP 100mg/325mg/15mg Tablet precisely as prescribed by your doctor. Numrex SP 100mg/325mg/15mg Tablet may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.

Do not take Numrex SP 100mg/325mg/15mg Tablet if you are allergic to any of its contents. Numrex SP 100mg/325mg/15mg Tablet should not be used in patients with liver failure, severe kidney failure, heart failure, gastric ulcers, bleeding disorders, and alcohol or drug abuse. Before taking Numrex SP 100mg/325mg/15mg Tablet, inform your doctor if you are pregnant or breastfeeding. Numrex SP 100mg/325mg/15mg Tablet should not be given to children below 12 years of age. In elderly people, Numrex SP 100mg/325mg/15mg Tablet may be given with caution. Alcohol should not be taken while using Numrex SP 100mg/325mg/15mg Tablet as it further increases the risk of liver damage. Numrex SP 100mg/325mg/15mg Tablet may not affect your ability to drive. However, do not drive or operate heavy machinery if you feel dizzy.

Numrex SP 100mg/325mg/15mg Tablet is a combination medicine that contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). Paracetamol is an analgesic and antipyretic. Both medicines can reduce pain and fever. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. Serratiopeptidase is an enzyme. It causes thinning of the fluids around the damaged tissue, thereby making fluid drainage easier in the swollen tissue. This effect reduces swelling and promotes faster healing. Together, Numrex SP 100mg/325mg/15mg Tablet can effectively reduce pain, swelling, and inflammation.

• Nausea
• Vomiting
• Indigestion
• Stomach pain
• Headache
• Heartburn
• Diarrhoea

Numrex SP 100mg/325mg/15mg Tablet may cause liver damage on higher doses or when used for prolonged periods. So, if you notice signs of liver damage such as loss of appetite, nausea, vomiting, unexplained weight loss, dark urine, and fatigue, or if you have abnormal liver function tests, discontinue the treatment immediately and consult your doctor. Do not use other analgesics while using Numrex SP 100mg/325mg/15mg Tablet. Numrex SP 100mg/325mg/15mg Tablet may have affected fertility, so it is not recommended for women trying to conceive. Numrex SP 100mg/325mg/15mg Tablet may interfere with blood clotting, so it is recommended to stop using this medicine at least 2 weeks before surgery.

Drug-Drug Interactions: Numrex SP 100mg/325mg/15mg Tablet may interact with other nonsteroidal anti-inflammatory drugs or pain killers (ibuprofen, diclofenac, and naproxen, etc.), blood thinners (warfarin and clopidogrel), medicines used to treat nausea and vomiting (metoclopramide and domperidone), an antidepressant (lithium), water pills, anticancer drug (methotrexate), and a medication used to suppress the immune system (cyclosporine), and medicine used to lower cholesterol levels (cholestyramine).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Numrex SP 100mg/325mg/15mg Tablet should not be used in patients with liver failure, severe kidney failure, heart failure, gastric ulcers, bleeding disorders, and alcohol or drug abuse.

• IBUPROFEN
• DICLOFENAC
• NAPROXEN
• WARFARIN
• CLOPIDOGREL
• METOCLOPRAMIDE
• DOMPERIDONE
• LITHIUM
• METHOTREXATE
• CYCLOSPORINE
• CHOLESTYRAMINE

• Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.

• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.

• In the chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids with a minimum level of chemicals called cytokines, which ramp up inflammation.

• Your sitting posture is important, especially when have pain and inflammation condition. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. It can be temporary (acute) or lifelong (chronic). Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. At the same time, chronic pain lasts lifelong and can occur due to severe inflammation or tissue damage, such as in cases of osteoarthritis and rheumatoid arthritis. Extreme tissue pain and inflammation caused due to sprains, strains, trauma, or post-surgery may require a prolonged amount of time to heal.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation, and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.