Numistel-C 40/10 Tablet belongs to the class of anti-hypertensives primarily taken for the treatment of hypertension (high blood pressure) and heart-related chest pain (angina). It comprises of Cilnidipine (calcium channel blocker) and Telmisartan (angiotensin receptor blocker). Hypertension is a lifelong or chronic condition in which the force exerted by the blood against the artery walls becomes so high that it leads to heart diseases. Angina is chest pain caused by reduced blood flow to the heart. 

Numistel-C 40/10 Tablet is composed of Cilnidipine and Telmisartan, prescribed to treat hypertension. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. As a result, the blood vessels widen, and supply to the heart increases, lowering the elevated blood pressure and the workload placed on the heart. Telmisartan works by blocking the action of certain substances that are responsible for tightening the blood vessels. It allows the blood to flow more smoothly and makes the heart more efficient at pumping blood throughout the body. Thus, it reduces the chance of having any heart attack or stroke in the future.

You can take Numistel-C 40/10 Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you how often you take your tablets based on your medical condition. Common side effects of Numistel-C 40/10 Tablet include sore back, diarrhoea, congested feeling, spinning sensation, soreness in the sinus. Most of these side effects of Numistel-C 40/10 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Don't stop taking Numistel-C 40/10 Tablet without your doctor advice. Sudden Stopping Numistel-C 40/10 Tablet may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms.  It is advised to drink plenty of fluids while taking this medicine to overcome dry mouth and extreme thirst. Patients suffering from kidney problems may be required to undergo regular blood creatinine, and potassium levels test as Numistel-C 40/10 Tablet affects electrolytes level in our body can be monitored.

Numistel-C 40/10 Tablet is composed of Cilnidipine and Telmisartan, prescribed to treat hypertension. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. As a result, the blood vessels widen, and supply to the heart increases, lowering the elevated blood pressure and the workload placed on the heart. Due to its calcium channel-blocking nature, it may also be prescribed to relieve the heart’s workload caused by a heart attack or stroke. Telmisartan works by blocking the action of certain substances that are responsible for tightening the blood vessels. It allows the blood to flow more smoothly and makes the heart more efficient at pumping blood throughout the body. Thus, it reduces the chance of having any heart attack or stroke in the future. Additionally, it has a protective effect on the kidney, and in the condition of diabetes.

• Sore back
• Diarrhoea
• Congested feeling
• Spinning sensation
• Soreness in the sinus

Numistel-C 40/10 Tablet should be taken with caution in patients with congestive heart failure, liver disease, peripheral oedema (swelling of hands/legs), cardiogenic shock (when heart suddenly can not pump sufficient blood), recent MI (myocardial infarction) or acute unstable angina (chest pain), severe aortic stenosis (when heart valves become diseased). You should monitor your blood pressure regularly to make sure the Numistel-C 40/10 Tablet is working efficiently. Besides this, prolonged intake of Numistel-C 40/10 Tablet can lead to lowering of blood pressure (hypotension). So, daily monitoring of blood pressure is advisable.

Drug-Drug interaction: Numistel-C 40/10 Tablet is known to interact with an anticancer drug (quinidine), antiepileptic medicine (phenytoin), anti TB drug (rifampicin), antibiotics (erythromycin), other blood pressure-lowering pills and anti-psychotic drugs, potassium-sparing diuretics or potassium supplements, lithium.

Drug-Food Interaction: Generally, no food interaction is found with this medicine. However, one should limit or avoid intake of alcoholic beverages.

Drug-Disease Interaction: Numistel-C 40/10 Tablet is contraindicated in patients with severe aortic stenosis (narrowed heart valve), cardiogenic shock (when suddenly the heart does not get enough blood supply), the recent history of unstable angina (chest pain), heart failure and hypotension (low blood pressure).

• QUINIDINE
• PHENYTOIN
• RIFAMPICIN+ISONIAZID
• ERYTHROMYCIN
• LITHIUM

• Keep your weight under control with a BMI of 19.5-24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products. 
• Limit intake of sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• If you are taking alcohol, then only one serving for women and two serving for men is advisable. 
• Quitting smoking is the best strategy to lower the risk of heart disease. 
• Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques. 
• Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor. 
• Try to include heart-healthy omega 3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to help lower your elevated blood pressure.

Sudden withdrawal may worsen angina (chest pain). However, if ou experience chest pain, consult your doctor immediately.

High blood pressure: It is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.