Nucala 100 mg Injection 1 ml belongs to the class of 'immunomodulators', primarily used to treat asthma. Asthma is a respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. Nucala 100 mg Injection 1 ml is used as an add-on maintenance treatment in severe asthma patients above six years of age and in patients with chronic rhinosinusitis with nasal polyps. It is also used in the treatment of hypereosinophilic syndrome and eosinophilic granulomatosis.

Nucala 100 mg Injection 1 ml consists of Mepolizumab as an active ingredient, which binds itself to interleukin-5 (IL-5) and stops it from attaching to its receptor on the surface of eosinophil white blood cells, specifically the alpha subunit of the receptor. It works by preventing the body's natural production of certain chemicals that increase asthma symptoms, like coughing, wheezing, chest pain, and breathing difficulties.

Nucala 100 mg Injection 1 ml may cause common side effects such as fever, back pain, itching, headache, sore throat, and breathing difficulty. These side effects resolve over time. Inform your doctor if any of these side effects bother you. Nucala 100 mg Injection 1 ml will be administered by a healthcare professional. Do not self-administer

Avoid taking Nucala 100 mg Injection 1 ml and inform your doctor if you are allergic to any component present in it. Before starting Nucala 100 mg Injection 1 ml, inform your doctor if you have any liver or kidney disease or active parasitic infections and are taking any inhaled corticosteroids. Pregnant and breastfeeding mothers should inform the physician before starting treatment with Nucala 100 mg Injection 1 ml. This medicine is contraindicated in cases of bronchospasm or status asthmaticus.

Nucala 100 mg Injection 1 ml contains Mepolizumab, which is a humanized recombinant IgG1 (Immunoglobulin G1) monoclonal antibody. It works by preventing the body's natural production of certain chemicals that increase asthma symptoms, like coughing, wheezing, chest pain, and breathing difficulties.

• Upper respiratory tract infection
• Fever
• Itching
• Back pain
• Headache
• Sore throat
• Pain at the site of injection
• Injection site reactions

To treat your condition effectually, continue taking Nucala 100 mg Injection 1 ml for the period that your doctor has prescribed. Avoid taking Nucala 100 mg Injection 1 ml if you are allergic to it or any other components present in it. Inform your doctor if you have any liver or kidney diseases, active parasitic infections, and are taking any inhaled corticosteroids before receiving Nucala 100 mg Injection 1 ml. Avoid close contact with people who have infections that can be easily spread. Nucala 100 mg Injection 1 ml is not recommended in children below six years of age as safety and efficacy are not established. Nucala 100 mg Injection 1 ml may cause severe allergic reactions, herpes zoster infections, and parasitic infections and reduce the effect of corticosteroid medicines. Hence, inform your doctor about your complete medication and medical history before taking Nucala 100 mg Injection 1 ml.

Drug-Drug Interactions: Nucala 100 mg Injection 1 ml may interact with anti-cancer drugs (ritlecitinib, deucravacitinib), vitamin supplements, and other medicines.

Drug-Food Interactions: Avoid alcohol consumption and smoking while being treated with Nucala 100 mg Injection 1 ml. 

Drug-Disease Interactions: Nucala 100 mg Injection 1 ml should be used with caution in cases of liver or kidney diseases, weak immune systems, and active parasitic infections.

• DEUCRAVACITINIB

• Maintain proper weight by following a healthy and well-balanced diet.
• Avoid smoking and alcohol consumption.
• Try to avoid stress by practising meditation or yoga.
• Try including selenium-rich food sources like Brazil nuts, yellowfin tuna, rice, beans, whole-wheat bread, dairy products, ham, chicken, turkey, beef, eggs, pork, baked beans, mushrooms, oatmeal, and spinach.
• Include zinc-rich sources like meat, shellfish, legumes, hemp seeds, nuts, eggs, dairy products, whole grains, potatoes, kale, and dark chocolate in your diet.
• Cut down on sugar, salt and processed foods.
• Drink plenty of water.

The doctor may suggest some tests to know the root cause of the respiratory disorder, such as Spirometry (check the narrowing of bronchial tubes) and Peak flow (check how difficult it is to exhale).

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The treatment for asthma includes medication, breathing exercises and self-care.