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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:21 PM IST
Norvelzo 3.5mg Injection is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition

BORTEZOMIB-3.5MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Norvelzo 3.5mg Injection

Norvelzo 3.5mg Injection belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Norvelzo 3.5mg Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Norvelzo 3.5mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). Norvelzo 3.5mg Injection must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of Norvelzo 3.5mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Norvelzo 3.5mg Injection for as long as your doctor has prescribed. Do not stop the Norvelzo 3.5mg Injection midway. Talk to your doctor before taking Norvelzo 3.5mg Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking Norvelzo 3.5mg Injection if you are pregnant or breastfeeding because this Norvelzo 3.5mg Injection can cause harmful effects on the unborn baby. Both women and men using this Norvelzo 3.5mg Injection should use birth control to avoid pregnancy.

Uses of Norvelzo 3.5mg Injection

Treatment of Multiple myeloma and Mantle cell lymphoma.

Medicinal Benefits

Norvelzo 3.5mg Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. Norvelzo 3.5mg Injection is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

Directions for Use

Norvelzo 3.5mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Norvelzo 3.5mg Injection

  • Nausea
  • Diarrhoea
  • Thrombocytopenia (low blood platelet count)
  • Neutropenia (too few neutrophils)
  • Peripheral neuropathy (nerves malfunction)
  • Fatigue (overtired)
  • Neuralgia (pain in the head or face)
  • Muscle pain, bone pain
  • Anaemia (low red blood cell Count)
  • Leukopenia (Low White Blood Cell Count)
  • High blood pressure
  • Constipation
  • Dehydration
  • Vomiting
  • Loss of appetite
  • Lymphopenia (Low lymphocytes Count)
  • Rash
  • Pyrexia (raised body temperature)
  • Anorexia (lack or loss of appetite for food)
  • Infections, including pneumonia, respiratory infections, bronchitis, fungal infections, coughing with phlegm, flu-like illness

Drug Warnings

To treat your condition effectually, continue taking Norvelzo 3.5mg Injection for as long as your doctor has prescribed. Do not stop the Norvelzo 3.5mg Injection midway. Talk to your doctor before taking Norvelzo 3.5mg Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with Norvelzo 3.5mg Injection. Avoid taking Norvelzo 3.5mg Injection if you are pregnant because this Norvelzo 3.5mg Injection can cause harmful effects on the unborn baby. Both women and men using this Norvelzo 3.5mg Injection should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with Norvelzo 3.5mg Injection and four months after your final dose of Norvelzo 3.5mg Injection.

Drug Interactions

Drug-Drug Interactions: Norvelzo 3.5mg Injection interacts with antifungal medication (ketoconazole), HIV medication (ritonavir), antibiotic medication (rifampicin), epilepsy medications (carbamazepine, phenytoin or phenobarbital), depression medication (St. John’s Wort), and oral antidiabetics.

Drug-Food Interactions: No food interaction was found.

Drug-Disease Interactions: Inform your doctor before taking Norvelzo 3.5mg Injection; it requires close monitoring if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), and hepatic disorders.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • RITONAVIR
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Special Advise

  • Norvelzo 3.5mg Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Norvelzo 3.5mg Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Norvelzo 3.5mg Injection may make your skin sensitive to sunlight.

Disease/Condition Glossary

Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs.

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Norvelzo 3.5mg Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Norvelzo 3.5mg Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Norvelzo 3.5mg Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Norvelzo 3.5mg Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Norvelzo 3.5mg Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Norvelzo 3.5mg Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Norvelzo 3.5mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Norvelzo 3.5mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Norvelzo 3.5mg Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

Country of origin

India
Other Info - NO66043

Author Details

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FAQs

Norvelzo 3.5mg Injection is used to treat multiple myeloma (a cancer of plasma cells) and mantle cell lymphoma (blood cancer).
Norvelzo 3.5mg Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.
Norvelzo 3.5mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Norvelzo 3.5mg Injection must not be administered into your spinal fluid (intrathecally).
Yes, Norvelzo 3.5mg Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Avoid taking Norvelzo 3.5mg Injection if you are pregnant because Norvelzo 3.5mg Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Norvelzo 3.5mg Injection.
Before you receive treatment with Norvelzo 3.5mg Injection, tell your doctor about all of your medical conditions. You should not receive Norvelzo 3.5mg Injection if you are allergic to bortezomib or any contents in Norvelzo 3.5mg Injection.
If not given an inappropriate dose, Norvelzo 3.5mg Injection can cause toxic effects, although not everyone gets it. So, Norvelzo 3.5mg Injection is prescribed by a doctor experienced in using medications to treat cancer only.
Norvelzo 3.5mg Injection contains bortezomib as its active substance. It belongs to a group of anti-cancer medicines.
No, Norvelzo 3.5mg Injection does not have any habit-forming potential.
Your doctor decides the dose of Norvelzo 3.5mg Injection based on your medical condition. Taking a double dose can lead to potential side effects.
You should call your doctor right away if you experience side effects like wheezing, chest tightness, swelling of the face or throat, difficulty breathing, seizures, or any unusual skin reactions. Also, seek immediate medical help if you have a sudden change in vision, numbness or tingling, severe stomach issues, unexplained bruising or bleeding, or if your symptoms worsen. Always contact your doctor if you notice any concerning changes in your condition.
You will know if Norvelzo 3.5mg Injection is working by noticing improvements in your condition. Regular scans will show if your tumor is reacting to the treatment. Your doctor will decide when these scans should be done. Always follow the doctor's advice as they will monitor your progress to assess its effectiveness.
To minimize the risk of infection while using Norvelzo 3.5mg Injection, maintain good hygiene, wash your hands frequently, and avoid contact with sick people. Protect any open wounds and be cautious with food handling. Take care not to harm yourself when using sharp objects like razor or nail cutters. Use a toothbrush with soft bristles to stop gum bleeding.
Norvelzo 3.5mg Injection may affect your lungs. However, it might cause allergies with symptoms like trouble breathing or chest tightness. If this happens, stop using Norvelzo 3.5mg Injection and get medical attention immediately
Yes, Norvelzo 3.5mg Injection may cause hair loss. If you experience unexpected hair thinning or loss, consult your doctor to avoid potential causes or talk if you have any concerns.
Avoid putting prolonged pressure on your limbs, maintain proper posture, be cautious when moving around and follow your doctor's recommendations for managing the symptoms. If you experience tingling or numbness in your arms or legs, inform your doctor immediately, as these could indicate nerve-related issues.
It is important to avoid prolonged sun exposure and UV light, as Norvelzo 3.5mg Injection can make your skin more sensitive. Wear protective clothing, sunglasses, and sunscreen to shield your skin. Keep track of your symptoms and consult your doctor to determine if Norvelzo 3.5mg Injection is the cause. Your doctor may adjust your treatment or suggest ways to manage the skin changes. Always follow their advice to ensure the treatment remains safe and effective.
To relieve constipation during treatment, focus on eating more fibre, staying hydrated, and staying active with light exercise. You can also consider using stool softeners after consulting your doctor. Establishing a routine for bowel movements and avoiding strain can also help. Always talk to your healthcare provider before trying new remedies.
You may experience nausea and extreme tiredness due to Norvelzo 3.5mg Injection, as these are among the side effects.These do not require any medical treatment as they will gradually reduce over time. However, please contact a doctor if these persist longer.
If you are experiencing a change in taste while using Norvelzo 3.5mg Injection, try staying hydrated, by using sugar-free gum or mint. Practicing good oral hygiene by brushing your teeth and tongue can also help. If the issue persists, consult your doctor for further advice on managing the side effect.

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