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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:54 PM IST

Nortrip 25 Tablet 15's is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night. It contains Nortriptyline, which works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain which communicate between brain cells, thereby regulating mood and preventing depression. Besides this, it also prevents the transmission of pain signals, thus providing relief from neuropathic pain. In some cases, you may experience certain common side effects such as increased heart rate, flushing, drowsiness, weight gain, difficulty in urination, orthostatic hypotension (sudden lowering of blood pressure on standing), dryness in the mouth, tingling in the arms or legs, blurred vision (dilated pupils). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Nortrip 25 Tablet 15's

Nortrip 25 Tablet 15's is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night. Depression is a mental illness or disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.

Nortrip 25 Tablet 15's contains Nortriptyline, which works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain. These messengers communicate with brain cells, thereby regulating mood and preventing depression. Besides this, Nortrip 25 Tablet 15's also transmits pain signals. Thus, it provides relief from neuropathic pain.

Take Nortrip 25 Tablet 15's as prescribed by your doctor. In some cases, you may experience certain common side effects such as increased heart rate, flushing, drowsiness, weight gain, difficulty in urination, orthostatic hypotension (sudden lowering of blood pressure on standing), dryness in the mouth, tingling in the arms or legs, blurred vision (dilated pupils). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Nortrip 25 Tablet 15's for as long as your doctor has prescribed. Inform your doctor if you have suicidal ideation or behaviour symptoms, heart disease, seizure disorders, glaucoma, thyroid problems, or kidney and liver problems. Do not take Nortrip 25 Tablet 15's if you are pregnant or breastfeeding unless prescribed by the doctor. The safety and effectiveness in children less than 18 years of age have not been established, so Nortrip 25 Tablet 15's should not be given to them. Avoid consuming alcohol along with Nortrip 25 Tablet 15's as it could lead to increased drowsiness and dizziness. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Rise slowly from sitting or lying position as Nortrip 25 Tablet 15's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Nortrip 25 Tablet 15's

Treatment of Depression

Medicinal Benefits

Nortrip 25 Tablet 15's belongs to a group of medicines called tricyclic antidepressants used to prevent depression. It works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treat depression. Nortrip 25 Tablet 15's prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

Directions for Use

Take Nortrip 25 Tablet 15's with or without food as advised by your doctor, and swallow it as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nortrip 25 Tablet 15's

  • Increased heart rate
  • Flushing
  • Drowsiness
  • Weight gain
  • Difficulty in urination
  • Constipation
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Dryness in the mouth
  • Tingling in the arms or legs
  • Blurred vision

Drug Warnings

Do not take Nortrip 25 Tablet 15's if you are known to be allergic to Nortrip 25 Tablet 15's. Inform your doctor if you have suicidal ideation or behaviour symptoms, have heart rhythm problems or hypotension, heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems. Do not take Nortrip 25 Tablet 15's if you are pregnant or breastfeeding unless prescribed by the doctor. Nortrip 25 Tablet 15's should not be given to children less than 18 years of age, as its safety and efficacy have not been established. Avoid consuming alcohol along with Nortrip 25 Tablet 15's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Nortrip 25 Tablet 15's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).

Drug Interactions

Drug-Drug Interaction: Nortrip 25 Tablet 15's may have interaction with monoamine oxidase inhibitors (medicines used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, selegiline)  medicine to treat high blood pressure (diltiazem, verapamil, guanethidine, debrisoquine, bethanidine, clonidine, reserpine, methyldopa ) pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen), antidepressant (bupropion, duloxetine, fluoxetine, sertraline), antihistamine (diphenhydramine, cetirizine), sedatives (zolpidem), muscle relaxant (cyclobenzaprine), medicines to treat fungal infections (fluconazole, terbinafine, ketoconazole, and itraconazole), anti-thyroid (levothyroxine).

Drug-Food Interaction: Avoid St. John´s Wort (a herbal remedy used for depression) and alcohol as it may increase the risk of side effects when taken along with Nortrip 25 Tablet 15's.

Drug-Disease Interaction: If you have suicidal ideation or behavior, have disease conditions such as heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems.

Drug-Drug Interactions Checker List

  • MOCLOBEMIDE
  • PHENELZINE
  • ISOCARBOXAZID
  • TRANYLCYPROMINE
  • SELEGILINE
  • DILTIAZEM
  • VERAMAPIL
  • GUANETHIDINE
  • CLONIDINE
  • METHYLDOPA
  • TRAMADOL
  • TRAZODONE
  • HYDROCODONE
  • OXYCODONE
  • BUPROPION
  • DULOXETINE
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • ZOLPIDEM
  • FLUCONAZOLE
  • TERBINAFINE
  • LEVOTHYROXINE SODIUM

Habit Forming

No

Diet & Lifestyle Advise

  • Maintaining a healthy diet and exercising regularly helps improve overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitters properly.
  • Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps produce the body’s natural antidepressants. It also relieves stress, improves mood, boosts self-esteem, and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Special Advise

  • Nortrip 25 Tablet 15's may increase the risk of suicidal thoughts and behaviour for people younger than 24 years. If you have symptoms of suicidal ideation or behaviour, please consult your doctor before taking Nortrip 25 Tablet 15's.
  • Do not use Nortrip 25 Tablet 15's if you have used an MAO inhibitor in the past 14 days, as a dangerous drug interaction could occur.
  • Nortrip 25 Tablet 15's may increase your risk of seizures. If you have a history of seizures, your doctor will monitor you more closely. 

Disease/Condition Glossary

Depression: It is a mood disorder characterized by the feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use and medical conditions.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nortrip 25 Tablet 15's as it may cause an increased sedative effect. Please consult a doctor before consuming alcohol with Nortrip 25 Tablet 15's.

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Pregnancy

Unsafe

Avoid taking Nortrip 25 Tablet 15's if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Nortrip 25 Tablet 15's; your doctor will decide whether breastfeeding mothers can take Nortrip 25 Tablet 15's or not.

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Driving

Caution

Nortrip 25 Tablet 15's may affect your ability to drive or operate machinery safely. Therefore, drive only if you are alerted after taking the Nortrip 25 Tablet 15's.

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Liver

Caution

Take Nortrip 25 Tablet 15's with caution, especially if you have a history of liver disease/conditions. Your doctor may adjust the dose as required.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Nortrip 25 Tablet 15's is not recommended for children under 18. Its safety and efficacy have not been established.

Country of origin

India

Manufacturer/Marketer address

Khasra No 62, 1St Floor, Old Gurgaon Road New Dehi
Other Info - NOR0573

Author Details

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FAQs

Nortrip 25 Tablet 15's is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night.
Nortrip 25 Tablet 15's contains Nortryptaline, which works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain that communicate between brain cells. Thus, it helps regulate mood and treats depression.
Do not take Nortrip 25 Tablet 15's if you are allergic to antidepressants (like nortriptyline, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, protriptyline, trimipramine), antiallergic (like carbamazepine, eslicarbazepine, oxcarbazepine and rufinamide), and MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others). Besides this, if you have used an SSRI antidepressant in the last 5 weeks like escitalopram, fluoxetine, citalopram, fluvoxamine, paroxetine, sertraline, trazodone, or vilazodone let your doctor know about this.
No, you should not take Nortrip 25 Tablet 15's if you have had a recent heart attack or stroke. Taking Nortrip 25 Tablet 15's after a heart attack can worsen your present health conditions Unless your doctor thinks the benefits outweigh the risks.
In some cases, Nortrip 25 Tablet 15's could make your skin sensitive and sunburn more easily. So, it is advisable to avoid sunlight or tanning beds. You can also wear protective clothing and use sunscreen (SPF 30 or more) when outside.
The common side effects of Nortrip 25 Tablet 15's include dizziness, blurred vision, headache, trouble with eye focusing, vision problems, constipation, dry mouth, high heartbeat (heart palpitation), tiredness, low blood pressure (especially on standing). Prolonged intake of Nortrip 25 Tablet 15's may increase the risk of eye pressure and heart attack. So, if you experience any of these symptoms immediately contact a doctor.
Nortrip 25 Tablet 15's could increase the pressure in your eyes. If you have a history of glaucoma or increased eye pressure, your doctor will monitor you more closely while you take nortriptyline.
No, If you have bipolar disorder that is not being treated, taking nortriptyline can make your condition worse.
Take the Nortrip 25 Tablet 15's as prescribed by your doctor. You can take it with or without food. Nortrip 25 Tablet 15's can make you feel sleepy. So it’s best to take it in the evening or before you go to bed. Swallow it whole with water. Do not crush, chew, or break it.
No, you should not stop taking Nortrip 25 Tablet 15's even if your pain is relieved, as it can lead to withdrawal symptoms such as nausea, headache, and weakness. It's important to consult your doctor before stopping Nortrip 25 Tablet 15's.
Maintain a healthy weight by focusing on a diet rich in fruits, vegetables, whole grains, and lean proteins, avoiding sugary foods, and by engaging in regular exercise. If you still have any concerns, discuss with your doctor.
The serious side effects of Nortrip 25 Tablet 15's include fast and irregular heartbeat, yellowing of eyes or skin, persistent headaches, confusion, muscle cramps, eye pain, eye swelling, and persistent constipation. If you experience any of these side effects, please consult your doctor immediately.
The onset of action for Nortrip 25 Tablet 15's can vary depending on the condition being treated. For depression, it typically takes 4 to 6 weeks to show full effect and for nerve pain, you may start to notice improvement within 1 to 3 weeks. Do not stop taking Nortrip 25 Tablet 15's after 1 or 2 weeks if you feel it’s not helping your symptoms. Give it at least 6 weeks to work. However consult your doctor if you have any concerns.
Take the Nortrip 25 Tablet 15's as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dose. Do not take a double dose to make up for a missed one.
Taking too much nortriptyline can cause overdose and result in symptoms such as irregular heartbeat, hallucinations, widened pupils, drowsiness, fever, vomiting, confusion, muscle stiffness, or seizures (fits). If these side effects persist or worsen, please consult your doctor immediately.
Avoid drinking alcohol while taking Nortrip 25 Tablet 15's as it may increase sleepiness or affect your alertness or concentration. Some medications should not be taken with Nortrip 25 Tablet 15's, discuss with your doctor before taking Nortrip 25 Tablet 15's and you should also avoid foods high in tyramine. These include aged cheeses, cured meats (like salami and pepperoni), and fermented foods.
While taking Nortrip 25 Tablet 15's, you should follow your doctor's advice regarding follow-up appointments. However consult your doctor immediately, if you experience any side effects.
Yes, Nortrip 25 Tablet 15's can cause sleepiness or drowsiness as a side effect, especially when you first start taking the medication. This side effect may decreases as your body adjusts to the medication, but if it persists or worsens, please consult your doctor.
No, taking Nortrip 25 Tablet 15's more than recommended will not increase its effectiveness. Instead, it can lead to severe side effects and toxicity, such as confusion, seizures, rapid heart rate, and potentially life-threatening conditions. It's important to take Nortrip 25 Tablet 15's in dosage prescribed by your doctor if you feel your current dose is not working effectively, consult your doctor.
Store Nortrip 25 Tablet 15's at room temperature in a dark and dry place. Keep it out of reach of children.

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