Nopline-25 Tablet 10's is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night. Depression is a mental illness or disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.

Nopline-25 Tablet 10's contains Nortriptyline, which works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain. These messengers communicate with brain cells, thereby regulating mood and preventing depression. Besides this, Nopline-25 Tablet 10's also transmits pain signals. Thus, it provides relief from neuropathic pain.

Take Nopline-25 Tablet 10's as prescribed by your doctor. In some cases, you may experience certain common side effects such as increased heart rate, flushing, drowsiness, weight gain, difficulty in urination, orthostatic hypotension (sudden lowering of blood pressure on standing), dryness in the mouth, tingling in the arms or legs, blurred vision (dilated pupils). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Nopline-25 Tablet 10's for as long as your doctor has prescribed. Inform your doctor if you have suicidal ideation or behaviour symptoms, heart disease, seizure disorders, glaucoma, thyroid problems, or kidney and liver problems. Do not take Nopline-25 Tablet 10's if you are pregnant or breastfeeding unless prescribed by the doctor. The safety and effectiveness in children less than 18 years of age have not been established, so Nopline-25 Tablet 10's should not be given to them. Avoid consuming alcohol along with Nopline-25 Tablet 10's as it could lead to increased drowsiness and dizziness. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Rise slowly from sitting or lying position as Nopline-25 Tablet 10's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Keep your doctor informed about your health condition and medicines to rule out any side effects.

Nopline-25 Tablet 10's belongs to a group of medicines called tricyclic antidepressants used to prevent depression. It works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treat depression. Nopline-25 Tablet 10's prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

• Increased heart rate
• Flushing
• Drowsiness
• Weight gain
• Difficulty in urination
• Constipation
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Dryness in the mouth
• Tingling in the arms or legs
• Blurred vision

Do not take Nopline-25 Tablet 10's if you are known to be allergic to Nopline-25 Tablet 10's. Inform your doctor if you have suicidal ideation or behaviour symptoms, have heart rhythm problems or hypotension, heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems. Do not take Nopline-25 Tablet 10's if you are pregnant or breastfeeding unless prescribed by the doctor. Nopline-25 Tablet 10's should not be given to children less than 18 years of age, as its safety and efficacy have not been established. Avoid consuming alcohol along with Nopline-25 Tablet 10's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Nopline-25 Tablet 10's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).

Drug-Drug Interaction: Nopline-25 Tablet 10's may have interaction with monoamine oxidase inhibitors (medicines used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, selegiline)  medicine to treat high blood pressure (diltiazem, verapamil, guanethidine, debrisoquine, bethanidine, clonidine, reserpine, methyldopa ) pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen), antidepressant (bupropion, duloxetine, fluoxetine, sertraline), antihistamine (diphenhydramine, cetirizine), sedatives (zolpidem), muscle relaxant (cyclobenzaprine), medicines to treat fungal infections (fluconazole, terbinafine, ketoconazole, and itraconazole), anti-thyroid (levothyroxine).

Drug-Food Interaction: Avoid St. John´s Wort (a herbal remedy used for depression) and alcohol as it may increase the risk of side effects when taken along with Nopline-25 Tablet 10's.

Drug-Disease Interaction: If you have suicidal ideation or behavior, have disease conditions such as heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems.

• MOCLOBEMIDE
• PHENELZINE
• ISOCARBOXAZID
• TRANYLCYPROMINE
• SELEGILINE
• DILTIAZEM
• VERAMAPIL
• GUANETHIDINE
• CLONIDINE
• METHYLDOPA
• TRAMADOL
• TRAZODONE
• HYDROCODONE
• OXYCODONE
• BUPROPION
• DULOXETINE
• DIPHENHYDRAMINE
• CETIRIZINE
• ZOLPIDEM
• FLUCONAZOLE
• TERBINAFINE
• LEVOTHYROXINE SODIUM

• Maintaining a healthy diet and exercising regularly helps improve overall health and boosts self-esteem.
• Regularly attend therapy sessions.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitters properly.
• Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
• Exercising helps produce the body’s natural antidepressants. It also relieves stress, improves mood, boosts self-esteem, and provides restful sleep.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Nopline-25 Tablet 10's may increase the risk of suicidal thoughts and behaviour for people younger than 24 years. If you have symptoms of suicidal ideation or behaviour, please consult your doctor before taking Nopline-25 Tablet 10's.
• Do not use Nopline-25 Tablet 10's if you have used an MAO inhibitor in the past 14 days, as a dangerous drug interaction could occur.
• Nopline-25 Tablet 10's may increase your risk of seizures. If you have a history of seizures, your doctor will monitor you more closely. 

Depression: It is a mood disorder characterized by the feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use and medical conditions.