NOBEL MR 2MG TABLET is a combination medicine used to relieve pain due to muscle spasms such as arthritis, muscle pain, tooth pain, bone and joint pain, headache, and period pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
 
NOBEL MR 2MG TABLET contains Nimesulide (analgesic), Paracetamol (mild analgesic and fever reducer), and Tizanidine (muscle relaxant). Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, NOBEL MR 2MG TABLET helps in reducing pain due to muscle spasms.
 
You are advised to take NOBEL MR 2MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as nausea, vomiting, dizziness, dry mouth, and diarrhoea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. NOBEL MR 2MG TABLET may cause dizziness, so drive with caution. NOBEL MR 2MG TABLET should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with NOBEL MR 2MG TABLET as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects. 

NOBEL MR 2MG TABLET is a combination of three drugs, namely: Tizanidine, Nimesulide, and Paracetamol. NOBEL MR 2MG TABLET is a combination medicine used to relieve pain and inflammation associated with osteoarthritis,  muscle pain, tooth pain, bone and joint pain, headache, and period pain. Tizanidine is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Nimesulide and Paracetamol are analgesics that work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Together, NOBEL MR 2MG TABLET helps in relieving pain due to muscle spasms. 

• Nausea
• Vomiting
• Dizziness
• Diarrhoea
• Dry mouth
• Loss of appetite
• Indigestion

Do not take NOBEL MR 2MG TABLET if you are allergic to any of its contents, if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine, or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. NOBEL MR 2MG TABLET may cause dizziness, so drive only if you are alert. NOBEL MR 2MG TABLET is not recommended for children as safety and effectiveness have not been established. Stop taking NOBEL MR 2MG TABLET and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other analgesic for pain relief along with NOBEL MR 2MG TABLET unless prescribed.  

Drug-Drug Interactions: NOBEL MR 2MG TABLET may interact with pain killers (hydrocodone), anti-depressants (escitalopram, duloxetine, sertraline), anti-psychotic (lithium), anti-rheumatoid (methotrexate), immunosuppressants (cyclosporin), hypnotic (zolpidem), anti-convulsant (pregabalin), antihistamine (diphenhydramine, cetirizine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anaemia, heart, kidney, or liver problems.

• HYDROCODONE
• ESCITALOPRAM
• DULOXETINE
• SERTRALINE
• LITHIUM
• METHOTREXATE
• CYCLOSPORINE
• ZOLPIDEM
• PREGABALIN
• DIPHENHYDRAMINE
• CETIRIZINE

• Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Avoid freezing and hot temperatures.
• Avoid wearing tight-fitting clothes, instead, wear loose garments.
• Rest well, and get plenty of sleep.
• To avoid developing pressure sores, change your position every two hours.
• Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
• Stay hydrated, drink plenty of water.

• Do not use NOBEL MR 2MG TABLET when you need muscle tone for safe balance and body movement during various activities. In some cases, it may be dangerous for you to have reduced muscle tone.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute or chronic, can be localized or wide-spread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure, or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, and soreness

Arthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation, and tenderness.