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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Niftran 100 Capsule is used to prevent and treat bacterial infections like urinary tract infections (UTIs), including Bladder Infection (cystitis). It is also used to treat kidney infections. It contains Nitrofurantoin, which kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections. It may cause common side effects like nausea, vomiting, diarrhoea, loss of appetite and headaches. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Niftran 100 Capsule

Niftran 100 Capsule is used to prevent and treat bacterial infections like urinary tract infections (UTIs) and cystitis. Besides this, it is also used to treat kidney infections. A urine infection is often called a urinary tract infection (or simply, UTI). Most urine infections are caused by germs (bacteria).

Niftran 100 Capsule contains nitrofurantoin, which kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections.

During the treatment, you may observe some common side effects like feeling sick (nausea), vomiting, diarrhoea, loss of appetite and headaches. However, if these side effects persist, STOP TAKING your medicine and go to a doctor immediately.

You should take Niftran 100 Capsule only if your doctor has prescribed it to you. Most bacterial infections get treated within one week, while some conditions might take longer. If you stop taking it too early, the infection may return or worsen. So, it would be best if you tried to complete the prescribed dosage.

Do not take Niftran 100 Capsule if you are allergic to amoxicillin, penicillin antibiotics, have liver/kidney problems, and had any vaccinations. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Niftran 100 Capsule . Niftran 100 Capsule should not be used during labour or delivery because there is a possibility that its use at this stage may affect the baby. If you want to breastfeed, please consult your doctor first.

Uses of Niftran 100 Capsule

Niftran 100 Capsule is used in the treatment of bacterial infections like urinary tract infections (UTIs), including bladder infections, cystitis, and kidney infections. The detailed uses of Niftran 100 Capsule are as follows:

  • Urinary tract infections (UTIs): Niftran 100 Capsule treats urinary tract infections caused by bacteria like E. coli, by stopping the growth of bacteria, helping to relieve symptoms and clear the infection.
  • Bladder Infection: Niftran 100 Capsule treats bladder infections by killing the bacteria that cause the infection, helping to relieve symptoms like burning during urination and frequent urination.
  • Cystitis: Niftran 100 Capsule is commonly used to treat cystitis, which is inflammation of the bladder often caused by bacterial infections. It helps to alleviate symptoms and clear the infection.
  • Kidney infections: Niftran 100 Capsule may also provide relief from symptoms associated with kidney infections, which are often caused by bacteria.

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Directions for Use

  • Niftran 100 Capsule can be taken with or without food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Niftran 100 Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Niftran 100 Capsule contains antibiotic Nitrofurantoin, which helps in treating and preventing a wide range of bacterial infections like urinary tract infections, cystitis and kidney infections.
  • This medicine is mainly effective for conditions caused by most susceptible bacteria (susceptible strains of Escherichia coli, enterococci, staphylococci, Citrobacter, Klebsiella and Enterobacter).
  • It is bactericidal in nature and works by killing bacteria that cause infections by preventing the formation of the cell wall required for living.
  • Niftran 100 Capsule also inhibits the repair of bacterial cells. Altogether, it kills the bacteria.

How Niftran 100 Capsule Works

Niftran 100 Capsule contains Nitrofurantoin. When you take Niftran 100 Capsule , your body immediately filters it out of your blood and into your urine. If you have a urinary tract infection, this indicates that the treatment is concentrated at the site of illness. On the other hand, nitrofurantoin kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Niftran 100 Capsule

Do not take more than the prescribed dose of Niftran 100 Capsule as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Niftran 100 Capsule if you are allergic to it or any of its components.
  • Also, avoid taking Niftran 100 Capsule if you have/had a severe reaction to Niftran 100 Capsule or any other medicines in the past, or inherited conditions such as porphyria (a blood disorder), glucose-6-phosphate dehydrogenase (G6PD) deficiency,  severe kidney disease, diabetes, or any illness-causing severe weakness, anaemia or vitamin B deficiency.
  • Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, a joint or tendon disorder such as rheumatoid arthritis, seizures (fits), epilepsy or if you participate in regular physical activity.
  • Taking Niftran 100 Capsule may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death.
  • Grapefruit, a calcium-rich food, should be avoided along with Niftran 100 Capsule .
  • Additionally, exposure to sunlight should be avoided while taking Niftran 100 Capsule , as it may increase phototoxicity or photosensitivity.
  • Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Niftran 100 Capsule .

Drug-Drug Interactions

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NitrofurantoinEtidocaine
Severe
NitrofurantoinMepivacaine
Severe

Drug-Drug Interactions

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NitrofurantoinEtidocaine
Severe
How does the drug interact with Niftran 100 Capsule:
Coadministration of Niftran 100 Capsule with Etidocaine may cause methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Co-administration of Niftran 100 Capsule with Etidocaine can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include a condition called methemoglobinemia, problems with your heart or lungs, your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
NitrofurantoinMepivacaine
Severe
How does the drug interact with Niftran 100 Capsule:
Combining Niftran 100 Capsule with Mepivacaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Niftran 100 Capsule and Mepivacaine together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away: gray skin color, feeling sick, headache, feeling dizzy or lightheaded, tiredness, trouble breathing, fast or shallow breathing, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
NitrofurantoinTetracaine
Severe
How does the drug interact with Niftran 100 Capsule:
Combining Niftran 100 Capsule with Tetracaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Niftran 100 Capsule and Tetracaine together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away if you experience your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Niftran 100 Capsule:
Combining Niftran 100 Capsule with Procaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule (the red blood pigment) is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking Niftran 100 Capsule with Procaine together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, and feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Niftran 100 Capsule:
Taking Lidocaine with Niftran 100 Capsule may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Niftran 100 Capsule with Lidocaine together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NitrofurantoinBCG vaccine
Severe
How does the drug interact with Niftran 100 Capsule:
When BCG vaccine is used with Niftran 100 Capsule, its effectiveness may be reduced.

How to manage the interaction:
Taking Niftran 100 Capsule with BCG vaccine together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice. Do not stop using any medications without consulting a doctor.
How does the drug interact with Niftran 100 Capsule:
Taking Bupivacaine and Niftran 100 Capsule may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking bupivacaine and Niftran 100 Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
NitrofurantoinSodium nitrite
Severe
How does the drug interact with Niftran 100 Capsule:
Combining Niftran 100 Capsule with Sodium nitrite can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking Niftran 100 Capsule with Sodium nitrite together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away if you experience gray skin color, nausea, a headache, feeling dizzy or lightheaded, being tired, having trouble breathing, having a fast or irregular heartbeat, and feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Niftran 100 Capsule:
Coadministration of Niftran 100 Capsule with leflunomide can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Niftran 100 Capsule and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NitrofurantoinLomitapide
Severe
How does the drug interact with Niftran 100 Capsule:
Coadministration of Lomitapide with Niftran 100 Capsule may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Niftran 100 Capsule and Lomitapide, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, joint pain, swelling, bleeding, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or liver damage. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Niftran 100 Capsule to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
  • Avoid taking calcium-enriched foods and drinks, as it might affect the working of Niftran 100 Capsule .
  • Avoid intake of alcoholic beverages with Niftran 100 Capsule as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Niftran 100 Capsule in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

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Alcohol

Consult your doctor

No reported interaction with Niftran 100 Capsule . But, It is best to consult the physician before taking medication.

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Pregnancy

Caution

Niftran 100 Capsule can be safely taken by pregnant women if prescribed by the doctor. But do not take nitrofurantoin during labour and childbirth, as there's a chance that it can affect the baby's blood.

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Breast Feeding

Consult your doctor

Niftran 100 Capsule is excreted in breast milk. Caution should be exercised, and it is advisable to consult a doctor before using it.

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Driving

Unsafe

Niftran 100 Capsule may cause dizziness and drowsiness, and the patient should not drive or operate machinery.

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Liver

Consult your doctor

If you have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

Niftran 100 Capsule is contraindicated in patients with renal dysfunction and patients with an eGFR of less than 45 ml/minute. It is advisable to consult a doctor before using it.

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Children

Safe if prescribed

Niftran 100 Capsule can be given to children but under child specialist medical supervision. Niftran 100 Capsule is prescribed to the children to treat complicated urinary tract infections.

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Heart

Niftran 100 Capsule is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Niftran 100 Capsule should be used under caution in geriatric patients as it can lead to adverse effects. Please consult your physician.

FAQs

Niftran 100 Capsule is used to treat bacterial infections like urinary tract infections (UTIs), including bladder infections, cystitis and kidney infections.

Niftran 100 Capsule kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections.

Niftran 100 Capsule belongs to the class of penicillin antibiotic. Niftran 100 Capsule is a broad-spectrum antibiotic effective against a wide range of bacteria. On the other hand, penicillin is a narrow-spectrum antibiotic effective against less number of bacteria.

No. You should complete the full course of Niftran 100 Capsule as prescribed by your doctor. After completing the full course of Niftran 100 Capsule will work. It is important that you take Niftran 100 Capsule at the right dose, right times and for the right numbers of days.

Niftran 100 Capsule does not work against viral infection. So, treating common cold and cough should not be taken.

Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - NIF0007

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