Nex 400mcg/1ml Injection is an opioid antagonist used to treat opioid overdose. This medicine is given as an emergency treatment where the use of high-potency opioids as a chemical weapon is suspected and as temporary prophylaxis of respiratory and/or central nervous system depression in military personnel and chemical incident responders.

Nex 400mcg/1ml Injection contains Naloxone, which belongs to the class of opioid receptor antagonists. It works by blocking the effect of opioid receptors and blocks the effects. Thereby it helps treat opioid overdose.

Nex 400mcg/1ml Injection may cause certain side effects such as nausea, vomiting, injection site reactions, dizziness, and headache.  If Nex 400mcg/1ml Injection causes any serious discomfort, speak with a doctor. Nex 400mcg/1ml Injection will be administered by the physician in an emergency.

Nex 400mcg/1ml Injection is generally given on an emergency basis. The patient's caregiver should inform the doctor about his/her previous medical and medication history beforehand. Also, inform the doctor if the patient is pregnant, planning to become pregnant, or breastfeeding.

Nex 400mcg/1ml Injection contains Naloxone, which belongs to the class of medications called 'opioid-antagonist' used to treat opioid dependence. It works by blocking the effect of opioid receptors and thereby blocks the effects of opioids. It is used along with counselling and social support to help patients dependent on opioid drugs. This medicine is also used after surgery to reverse the effects of opiates given during surgery.

• Injection site reactions (pain, burning or redness)
• Hot flushes
• Syncope (loss of consciousness)
• Dizziness
• Headache

Nex 400mcg/1ml Injection is generally given on an emergency basis. The patient's caregiver should inform the doctor about his/her previous medical and medication history beforehand. Also, let the doctor know if the patient is pregnant, planning to become pregnant, or breastfeeding.  Inform your doctor if you have increased blood pressure, liver/kidney disease, or are taking any medications before receiving Nex 400mcg/1ml Injection. Do not use other medications without the doctor's notice, especially opioid-containing ones. It may cause precipitation of severe opioid withdrawal and risk of recurrent respiratory and central nervous system depression. Hence, the patient should be monitored carefully after administration of Nex 400mcg/1ml Injection.

Drug-Drug interactions: Nex 400mcg/1ml Injection may interact with opioid- medications (e.g. codeine, hydrocodone) and sedative medications (e.g. droperidol).

Drug-Food interactions: Consumption of alcohol should be avoided.

Drug-Disease interactions: Nex 400mcg/1ml Injection may interact with various disease conditions, including kidney disease & liver disease, depression and suicidal tendencies.

• CODEINE
• HYDROCODONE
• DROPERIDOL

• Eat foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread, along with protein in meals.
• A patient should consume supplements and vitamins as per their doctor's recommendation.
• The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, juice or lemonade with sparkling water, etc.
• Get physical activity and enough rest.
• Reduce caffeine and stop smoking, if possible.

• It is recommended to monitor liver function tests regularly.
• Strictly warn patients against the use of opioids while on treatment with Nex 400mcg/1ml Injection.
• Monitor for injection-site reactions.

Opioid overdose: Opioid overdose is a condition when someone takes opioid medicine (fentanyl) more than prescribed. This can further make the individual physically dependent on a substance. In this case, instead of making enough of its own opioids, the body has begun to rely on outside opioids to maintain normal function. Symptoms may include vomiting or making gurgling noises, blue skin due to poor circulation, slow breathing, unresponsiveness, confusion, etc.