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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nevir-ER Tablet is used to treat Human Immunodeficiency Virus (HIV) Infection. It contains Neviparine, which belongs to the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. It works by inhibiting the HIV reverse transcriptase enzymes necessary for the virus's DNA reproduction. This inhibits DNA replication and thereby prevents the further spread of infection.

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Whats That

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Composition :

NEVIRAPINE-400MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Nevir-ER Tablet

Nevir-ER Tablet is an antiretroviral medicine used in the treatment of HIV. Human Immunodeficiency Virus (HIV) is a retroviral infection that attacks and damages the cells of the immune system. This weakens the ability to fight against infections and diseases. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Syndrome (AIDS). Nevir-ER Tablet is combined with other antiretroviral medicines to treat HIV infection.

Nevir-ER Tablet contains Neviparine, which belongs to the class of non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by inhibiting the HIV reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of DNA replication and thereby prevents further spread of infection.

Nevir-ER Tablet may cause side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, fatigue, diarrhoea, myalgia (muscle pain), skin rash and other allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Nevir-ER Tablet should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on your health condition. Do not take more than the recommended dose.

Nevir-ER Tablet should be avoided if you are allergic to it. This medicine is contraindicated in patients with moderate to severe hepatic impairment or used as an occupational or non-occupational post-exposure prophylaxis. Nevir-ER Tablet is known you cause fatal or non-fatal hepatotoxicity and skin disorders. Hence, careful monitoring should be done during the first 18 weeks of the treatment initiation. Before taking this medicine, inform your doctor if you have liver/kidney disease, hypersensitivity reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, cirrhosis, or hepatic fibrosis. If you are pregnant and breastfeeding, let your doctor know before taking Nevir-ER Tablet . Nevir-ER Tablet should be used in children only if recommended by the doctor. 

Uses of Nevir-ER Tablet

Treatment of Human Immunodeficiency Virus (HIV) Infection

Directions for Use

Take this medicine as advised by your doctor. It should be taken with or without food. Swallow as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Nevir-ER Tablet contains Neviparine, which belongs to the class of non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by inhibiting the HIV reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of DNA replication and thereby prevents further spread of infection. Nevir-ER Tablet is used in combination with other antiretroviral medicines to help reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV. 

How Nevir-ER Tablet Works

Nevir-ER Tablet contains Neviparine, which belongs to the class of non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by inhibiting the HIV reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of DNA replication and thereby prevents further spread of infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nevir-ER Tablet

  • Nausea
  • Abdominal pain
  • Vomiting
  • Joint ache
  • Fatigue
  • Loss of appetite
  • Myalgia
  • Skin rash
  • Diarrhoea
  • Headache

What if I have taken an overdose of Nevir-ER Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Nevir-ER Tablet may include dizziness, difficulty falling asleep or staying asleep, excessive tiredness, fever, headache, nausea, painful red bumps on the skin, rash, swelling of the hands, feet, ankles, or lower legs, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Nevir-ER Tablet should be avoided if you are allergic to it. This medicine is contraindicated in patients with moderate to severe hepatic impairment or used as an occupational or non-occupational post-exposure prophylaxis. This medicine should only be prescribed in patients with CD4+ greater than 250 cells/mm3 (females) and 400 cells/mm3 (males). Inform your doctor about your medical history and the medicines you take to prevent possible interactions. Nevir-ER Tablet is known you cause fatal or non-fatal hepatotoxicity and skin disorders. Hence, careful monitoring should be done during the first 18 weeks of the treatment initiation. If the patient develops any signs or symptoms of hepatitis, increased transaminase, rash, or hypersensitivity reactions, Nevir-ER Tablet should be discontinued immediately. This medicine may cause dizziness; hence, avoid driving or operating machines while taking Nevir-ER Tablet . Before taking this medicine, inform your doctor if you have liver/kidney diseases, hypersensitivity reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, cirrhosis, or hepatic fibrosis. If pregnant and breastfeeding, inform your doctor before taking Nevir-ER Tablet . Nevir-ER Tablet should be used in children only if recommended by the doctor. If prescribed, the child should be carefully monitored for any changes. Nevir-ER Tablet treats the infection but does not cure or prevent it.

Drug-Drug Interactions

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NevirapineAtazanavir
Critical
NevirapineRanolazine
Critical

Drug-Drug Interactions

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NevirapineAtazanavir
Critical
How does the drug interact with Nevir-ER Tablet 30's:
When Atazanavir is taken with Nevir-ER Tablet 30's, it can reduce the levels and side effects of atazanavir & increase the blood levels and effects of Nevir-ER Tablet 30's.

How to manage the interaction:
Taking Nevir-ER Tablet 30's with Atazanavir is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineRanolazine
Critical
How does the drug interact with Nevir-ER Tablet 30's:
Co-administration of Nevir-ER Tablet 30's with Ranolazine may significantly reduce the blood levels of Ranolazine. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Nevir-ER Tablet 30's with Ranolazine is generally avoided as it can lead to an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
NevirapineHydrocodone
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Co-administration of Nevir-ER Tablet 30's with Hydrocodone may reduce the blood levels of Hydrocodone. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Nevir-ER Tablet 30's with Hydrocodone can result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like pain, watery eyes, runny nose, sneezing, yawning, sweating, fever, chills, restlessness, irritability, anxiety, depression, big pupils, shaking, fast heartbeat, twitching, loss of appetite, feeling sick, throwing up, diarrhoea, losing weight or taking too much medicine, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
NevirapineOlaparib
Severe
How does the drug interact with Nevir-ER Tablet 30's:
When Olaparib is taken with Nevir-ER Tablet 30's may reduce the blood levels of Olaparib. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Nevir-ER Tablet 30's and Olaparib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting a doctor.
NevirapineDolutegravir
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Taking dolutegravir with Nevir-ER Tablet 30's can reduce the effectiveness of dolutegravir.

How to manage the interaction:
Although taking Dolutegravir and Nevir-ER Tablet 30's together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.
NevirapineUlipristal
Severe
How does the drug interact with Nevir-ER Tablet 30's:
When Ulipristal is taken with Nevir-ER Tablet 30's may reduce the blood levels of Ulipristal. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Nevir-ER Tablet 30's and Ulipristal together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without consulting a doctor.
NevirapineRifampicin
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Taking Nevir-ER Tablet 30's with rifampicin can decrease the blood levels of Nevir-ER Tablet 30's, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Nevir-ER Tablet 30's and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
NevirapineLeflunomide
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Coadministration of Nevir-ER Tablet 30's and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Nevir-ER Tablet 30's, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineMipomersen
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Coadministration of Nevir-ER Tablet 30's and Mipomersen can increase the risk and severity of liver problems.

How to manage the interaction:
Although taking Nevir-ER Tablet 30's and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding make sure to contact your doctor immediately. Do not stop using any medications without a doctor's advice.
NevirapineVoclosporin
Severe
How does the drug interact with Nevir-ER Tablet 30's:
Coadministration of Nevir-ER Tablet 30's with Voclosporin may lower voclosporin blood levels, which might lessen how well it works to treat your disease.

How to manage the interaction:
Co-administration of Nevir-ER Tablet 30's with Voclosporin can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruit as it helps to boost your immune system. Try to take lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Get tested for other sexually transmitted infections, such as gonorrhoea or syphilis.
  • Try to reduce emotional and physical stress by spending time with your family or doing whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration.  
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injection or drug equipment.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Nevir-ER Tablet . Alcohol intake might increase the risk of stomach or intestine bleeding.

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Pregnancy

Consult your doctor

If you are pregnant or suspect you may be pregnant, inform your doctor before taking Nevir-ER Tablet . Your doctor will prescribe a suitable dose of this medicine to prevent maternal-fetal HIV transmission.

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Breast Feeding

Unsafe

Nevir-ER Tablet is excreted in milk. If you have HIV or are taking Nevir-ER Tablet , you should not breastfeed your baby.

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Driving

Unsafe

Avoid driving vehicles after taking Nevir-ER Tablet as it may cause fatigue.

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Liver

Caution

Nevir-ER Tablet can result in serious, sometimes fatal, liver damage. Inform your doctor if you have or have had a liver illness, particularly hepatitis B or C. Your doctor will most likely advise you not to take Nevir-ER Tablet .

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Kidney

Caution

Before using Nevir-ER Tablet , inform your doctor if you have or have ever had kidney disease, particularly if you are on dialysis treatment.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

FAQs

Nevir-ER Tablet is used to treat HIV infection.
Nevir-ER Tablet contains Neviparine, which works by inhibiting the HIV reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of viral replication and thereby prevents further spread of infection.
No, completing the entire treatment course prescribed by the doctor is always recommended. Sudden discontinuation of the medicine can lead to serious side effects. Your doctor will decide whether to stop the medication or not.
Nevir-ER Tablet does not cure HIV infection. However, it helps to control the disease and prevent opportunistic infections. Nevir-ER Tablet is used in combination with other anti-retroviral medicines.
Nevir-ER Tablet is an antiretroviral medicine. It contains Neviparine, which belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTI) used to treat HIV infection.
Yes, Nevir-ER Tablet is safe if taken in the dose and duration prescribed by the doctor.
Nevir-ER Tablet can be taken with or without food. Swallow it as a whole with a glass of water. Do not chew, crush, or break the medicine.
Yes, Nevir-ER Tablet is an effective antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) infection.
If you miss a dose of Nevir-ER Tablet , take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Nevir-ER Tablet may cause side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, fatigue, diarrhoea, myalgia (muscle pain), skin rash and other allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - NEV0080

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