Nervihope-Plus Capsule is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to damage to sensory nerves. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events that are usually not painful).

Nervihope-Plus Capsule contains Pregabalin, mecobalamin, alpha-lipoic acid, folic acid and pyridoxine. Pregabalin works by binding to the specific site on voltage-gated calcium channels, this helps relieve nerve pain and lowers the risk of seizures. Mecobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Nervihope-Plus Capsule helps in providing relief from neuropathic pain.

You are advised to take Nervihope-Plus Capsule for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, sleepiness, tiredness, dry mouth and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Nervihope-Plus Capsule without consulting your doctor as it could cause withdrawal symptoms. Consult your doctor if you are pregnant or breastfeeding. Nervihope-Plus Capsule causes drowsiness and dizziness, so drive only if you are alert. Nervihope-Plus Capsule is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Nervihope-Plus Capsule as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Nervihope-Plus Capsule is a combination of five drugs: Pregabalin, mecobalamin, alpha-lipoic acid, folic acid and pyridoxine. Nervihope-Plus Capsule is used to treat neuropathic pain. Pregabalin is an anti-convulsant that affects the chemicals in the brain that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels, this helps relieve nerve pain and lowers the risk of seizures. Mecobalamin is a vitamin that helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Pyridoxine (Vitamin B6) is also very useful in facilitating myelin and neurotransmitter synthesis. Alpha-lipoic acid is an antioxidant that helps in providing a protective effect on the nerve tissues and brain. Folic acid is a vitamin that helps in providing essential nutrients to the nerves. Together, Nervihope-Plus Capsule helps in providing relief from neuropathic pain.  Additionally, Nervihope-Plus Capsule may also be used to treat diabetic neuropathy, fibromyalgia and postherpetic neuralgia.

• Dizziness
• Sleepiness
• Dry mouth
• Oedema
• Tiredness

Do not take Nervihope-Plus Capsule if you are allergic to any of its contents. Inform your doctor before taking Nervihope-Plus Capsule if you have or had heart problems or bipolar syndrome. Please do not stop taking Nervihope-Plus Capsule without consulting your doctor as it could cause withdrawal symptoms. Consult your doctor before starting Nervihope-Plus Capsule if you are pregnant or breastfeeding. Nervihope-Plus Capsule may cause drowsiness and dizziness, so drive only if you are alert. Nervihope-Plus Capsule is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Nervihope-Plus Capsule as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions: Nervihope-Plus Capsule may interact with antidepressants (amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline), pain killer (codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol), anti-convulsant (gabapentin, phenobarbital, phenytoin), anti-anxiety (diazepam, alprazolam), anti-diabetic (metformin), immunosuppressant (methotrexate), anti-rheumatic (sulfasalazine), antibiotic (chloramphenicol), anti-cancer (altretamine) and anti-Parkinson’s (levodopa).

Drug-Food Interactions: Avoid alcohol consumption while taking Nervihope-Plus Capsule as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Nervihope-Plus Capsule may have interactions with disease conditions such as suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, malabsorption and anaemia.

• AMITRIPTYLINE
• MIRTAZAPINE
• FLUOXETINE
• DULOXETINE
• SERTRALINE
• CODEINE
• FENTANYL
• HYDROCODONE
• MORPHINE
• OXYCODONE
• TRAMADOL
• GABAPENTIN
• PHENOBARBITAL
• PHENYTOIN
• METFORMIN
• METHOTREXATE
• ALPRAZOLAM
• SULFASALAZINE
• CHLORAMPHENICOL
• LEVODOPA
• ALTRETAMINE

• Include food rich in vitamin B and D in your diet.
• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
• Exercising regularly helps in improving overall health and combating pain. 
• Rest well, get plenty of sleep.
• Try taking a warm bath as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
• Acupuncture can be helpful by stimulating pressure points.
• Using essential oils for massages can help increase circulation.

• People taking Nervihope-Plus Capsule should be closely monitored for suicidal thoughts or behaviour. Speak with your doctor immediately if you experience suicidal tendencies such as killing or harming yourself.

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).