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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:27 PM IST
Neomine 2.5mg Injection is used to treat Myasthenia gravis, paralytic ileus, and post-operative urinary retention. It contains Neostigmine. It increases levels of a neurotransmitter called acetylcholine by stopping the excess cholinesterase activity (an enzyme required to break down acetylcholine) involved in communication between nerve impulses and muscle movements. Neurotransmitters are chemical messengers that transmit the message from one nerve cell to another nerve cell, muscle cell, or gland cell. Thus, it helps in proper muscle functioning and prevents muscle weakness.
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Manufacturer/Marketer

Zydus Cadila

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Neomine 2.5mg Injection

Neomine 2.5mg Injection belongs to a group of medicines called 'anticholinesterase agents/acetylcholinesterase inhibitors,' primarily used to treat myasthenia gravis and to reverse the effects of anaesthesia medicines used during surgery. Neomine 2.5mg Injection is also used to treat paralytic ileus (a rare form of constipation) and postoperative urinary retention.

Neomine 2.5mg Injection contains 'Neostigmine.' It increases levels of a neurotransmitter called acetylcholine by stopping the excess cholinesterase activity (an enzyme required to break down acetylcholine) involved in communication between nerve impulses and muscle movements. Neurotransmitters are chemical messengers that transmit the message from one nerve cell to another nerve cell, muscle cell, or gland cell. Thus Neomine 2.5mg Injection helps in proper muscle functioning and prevents muscle weakness.

Neomine 2.5mg Injection will be administered by a health care professional, do not self-administer. Your dose and duration will be based on the severity of your medical condition. In some cases, you may experience common side effects, such as nausea, vomiting, slow heartbeat, abdominal cramp, diarrhoea, increased saliva production, dizziness, headache, trouble sleeping, and dry mouth. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor before using this medicine if you have a history of liver, heart or kidney diseases, asthma, stomach ulcer, fits, Parkinson's disease, overactive thyroid, or vagotonia/irritability of the vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions. Let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before starting Neomine 2.5mg Injection. Avoid consuming alcohol during the course to prevent unwanted side effects. Neomine 2.5mg Injection can be given to children if prescribed by the doctor; the dose depends on the child's age and weight.

Uses of Neomine 2.5mg Injection

Treatment of Myasthenia gravis, paralytic ileus, and post-operative urinary retention

Medicinal Benefits

Neomine 2.5mg Injection belongs to the group of medicines called 'anticholinesterase agents/cholinesterase inhibitors and is used to treat myasthenia gravis (muscle weakness). Neomine 2.5mg Injection contains 'Neostigmine'. It stops the excessive activity of cholinesterase, helping the muscles work properly. Additionally, Neomine 2.5mg Injection is used to treat paralytic ileus (a rare form of constipation) and postoperative urinary retention. It reverses the effects of neuromuscular blocking agents/anaesthesia medicines used during surgery. Neomine 2.5mg Injection affects the chemicals in the body, which are involved in communication between nerve impulses and muscle movements. Thereby, Neomine 2.5mg Injection treats muscle-associated disorders by improving muscle strength.

Directions for Use

A healthcare professional will administer it; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Neomine 2.5mg Injection

  • Nausea
  • Vomiting
  • Slow heartbeat
  • Abdominal cramp
  • Diarrhoea
  • Increased saliva production
  • Dizziness
  • Headache
  • Trouble sleeping
  • Dry mouth

Drug Warnings

Let your doctor know if you use any other medicines or supplements before using Neomine 2.5mg Injection. Brief your medical history if you have any liver or kidney diseases, heart diseases (coronary artery disease, irregular heartbeat), asthma, stomach ulcer, fits, urination problems, Parkinson's disease, overactive thyroid, and vagotonia before starting Neomine 2.5mg Injection. Please consult your doctor if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol to get the maximum benefits of the medicine and prevent the disease's aggravation. Drive or operate machinery only when you are alert and focused during the course.

Drug Interactions

Drug-Drug Interaction: Neomine 2.5mg Injection may interact with anaesthetics (halothane, cyclopropane), muscle relaxants (succinylcholine, suxamethonium), and antibiotics (neomycin, streptomycin).

Drug-Food Interaction: Avoid alcohol intake while being treated with Neomine 2.5mg Injection.

Drug-Disease Interaction: Let your doctor know if you have asthma, bradycardia (slow heart rate), bronchospasm, fits, overactive thyroid, stomach ulcer, coronary artery disease, urination problems, Parkinson's disease, or irritability of vagus nerve before starting Neomine 2.5mg Injection.

Drug-Drug Interactions Checker List

  • HALOTHANE
  • CYCLOPROPANE
  • SUCCINYLCHOLINE
  • SUXAMETHONIUM
  • NEOMYCIN
  • STREPTOMYCIN

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain proper weight by following a healthy diet.
  • Avoid smoking and alcohol consumption.
  • Try to avoid stress by practising meditation or yoga.
  • Include fruits and vegetables in your diet as they contain antioxidants.
  • Eat warm meals rather than hot meals, as heat aggravates the disease.
  • Try sipping a cold drink while having hot or warm meals.
  • Avoid foods that require a lot of chewing, like tough meats.
  • Exercise regularly to keep your muscles strong
  • Limit foods with high cholesterol and saturated fats.
  • Cut down on sugar, salt and processed foods.
  • Drink plenty of water.

Special Advise

Neomine 2.5mg Injection might interfere with the effects of skeletal muscle relaxants used in the surgery. 

Disease/Condition Glossary

Myasthenia gravis: It is an autoimmune neuromuscular disease that causes skeletal muscle weakness. The immune system mistakenly attacks its healthy tissues, damaging the neuromuscular membrane. This reduces the effect of acetylcholine, a neurotransmitter that plays a major role in the communication between nerve cells and muscles. Myasthenia gravis occurs when the communication between nerve cells and muscles becomes impaired. This prevents muscle contractions, thereby leading to muscle weakness. The most affected muscles are those of the face and eyes. Symptoms of myasthenia gravis include double vision, drooping eyelids, difficulty chewing or swallowing, weakness, problems with lifting objects, and trouble talking and walking.

Paralytic ileus: It is a condition in which there is obstruction of the intestine due to paralysis of intestinal muscles. This prevents the passage of food and leads to its accumulation in the intestine. Paralytic ileus occurs due to malfunctioning nerves and muscles in the intestine, thereby impairing digestive movement. 

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Alcohol

Caution

Avoid consuming alcohol during the course with Neomine 2.5mg Injection to prevent any undesirable side effects.

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Pregnancy

Caution

There is limited information on how Neomine 2.5mg Injection affects pregnancy. If you are pregnant or planning to conceive, inform your doctor before taking Neomine 2.5mg Injection.

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Breast Feeding

Caution

It is not known if Neostigmine is excreted into breast milk. Please inform your doctor before taking Neomine 2.5mg Injection if you are a breastfeeding mother.

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Driving

Caution

Neostigmine may make you feel dizzy and affect your ability to drive. It is advised not to drive or operate machinery while being treated with Neomine 2.5mg Injection if you are not mentally alert and focused.

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Liver

Caution

Please inform your doctor before receiving Neomine 2.5mg Injection if you have liver problems.

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Kidney

Caution

Please inform your doctor before receiving Neomine 2.5mg Injection if you have kidney disease.

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Children

Caution

Neomine 2.5mg Injection is recommended in children below 12 years of age only when prescribed by the doctor. The dosage depends on the child's age, weight and condition.

Country of origin

India
Other Info - NE70936

Author Details

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FAQs

Neomine 2.5mg Injection is used to treat Myasthenia gravis, paralytic ileus, and post-operative urinary retention.
Neomine 2.5mg Injection works by stopping the excessive cholinesterase activity (an enzyme necessary for the breakdown of a neurotransmitter called acetylcholine) involved in communication between nerve impulses and muscle movements. Thereby, Neomine 2.5mg Injection helps in proper muscle functioning and prevents muscle weakness.
Neomine 2.5mg Injection should be used with caution in the medical history of liver or kidney diseases, heart diseases (coronary artery disease, irregular heartbeat), peritonitis (inflammation of the membrane lining the abdominal wall and covering the abdominal organs), stomach ulcer, asthma, fits, urination problems, Parkinson's disease, overactive thyroid (hypothyroidism), and vagotonia. Please let your doctor know if you have any other medical problems before starting Neomine 2.5mg Injection.
Generally, women aged 20 to 40 and men aged 50 to 80 are affected by myasthenia gravis. High-risk factors for developing this disease include autoimmune diseases like rheumatoid arthritis and lupus, infections, surgical procedures, thyroid disease, and medications for malaria, heart arrhythmias and cancer.
Diabetes may trigger a stronger immune response due to an abnormal rise in blood sugar levels. This may further lead to the worsening of the myasthenia gravis.
Yes, Neomine 2.5mg Injection is used to treat myasthenia gravis. It helps in proper muscle functioning and prevents muscle weakness.
Neomine 2.5mg Injection should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Neomine 2.5mg Injection starts working within 10-20 minutes after administration. The duration of action lasts for up to 4 hours.
No, Neomine 2.5mg Injection is not a steroid. Neomine 2.5mg Injection contains Neostigmine, an anticholinesterase agent/acetylcholinesterase inhibitor.
Neomine 2.5mg Injection is not known to cause weight gain. Consult the doctor if you notice any changes in weight during treatment with Neomine 2.5mg Injection.
Yes, Neomine 2.5mg Injection is usually safe and well-tolerated medicine when used in the prescribed dose and duration.
The doctor will determine the dose of Neomine 2.5mg Injection based on your medical condition. Please consult the doctor if you get tired easily, as it could be due to the increased severity of myasthenia gravis.
Neomine 2.5mg Injection is indicated for the treatment of paralytic ileus (a rare form of constipation) only. It should not be used for constipation due to other causes. Consult the doctor if you have any concerns.
Since Neomine 2.5mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away.
No, Neomine 2.5mg Injection does not have any abuse potential. It is not a habit-forming medicine.
Neomine 2.5mg Injection should be used by people who are allergic to any of its components. It is also not recommended if you have an intestinal obstruction or cannot urinate, a condition where your bowel may no longer be functioning, peritonitis (an infection or inflammation of the outer layer of the stomach or intestines) or if you are taking certain muscle relaxants (Suxamethonium).
Neomine 2.5mg Injection may cause side effects such as nausea, vomiting, slow heartbeat, abdominal cramps, diarrhoea, dizziness, headache, trouble sleeping, and dry mouth. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

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