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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Naprosyn ES 500mg DR Tablet is a painkiller medicine used to relieve pain. This combination medicine has anti-inflammatory properties which work by blocking the action of the body's cyclo-oxygenase (COX) enzyme to produce prostaglandins that cause pain and swelling. You may experience common side effects like indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea.
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Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Naprosyn ES 500mg DR Tablet

Naprosyn ES 500mg DR Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers used to reduce and relieve pain. Pain is a highly unpleasant physical sensation caused by illness or injury.

Naprosyn ES 500mg DR Tablet combines Naproxen (painkiller) and esomeprazole (antacid). Naproxen is an anti-inflammatory drug that works by blocking the action of the body's cyclo-oxygenase (COX) enzyme to produce certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site, decreasing joint stiffness. Naproxen has been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. Hence, combined with esomeprazole (proton pump inhibitors), it reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Take Naprosyn ES 500mg DR Tablet as prescribed by your doctor. You are advised to take Naprosyn ES 500mg DR Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea. Most of these side effects of Naprosyn ES 500mg DR Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking this medicine, inform your doctor if you have any known allergy to Naproxen, esomeprazole, other NSAIDs, or other medications. If pregnant or breastfeeding, please inform your doctor before taking the Naprosyn ES 500mg DR Tablet . Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers. Patients with age above 65 years, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases, or bleeding disorders should use Naprosyn ES 500mg DR Tablet only when prescribed by a doctor. Keep your doctor informed about your health condition and all the medicines you take before taking Naprosyn ES 500mg DR Tablet to rule out any side effects.

Uses of Naprosyn ES 500mg DR Tablet

Treatment of Pain

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Naprosyn ES 500mg DR Tablet contains Naproxen and esomeprazole (antacid). Naproxen is an anti-inflammatory (reduces inflammation) and an analgesic (relieves pain) agent that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site, decreasing joint stiffness. It also treats fibrositis (muscle pain and stiffness), tenosynovitis (swelling of tendons), low back pain, strains, and sprains. NSAIDs such as Naproxen have been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. To reduce gastric discomfort and stomach ulceration risk, it is combined with esomeprazole (a proton pump inhibitor that inhibits gastric acid secretion) to reduce stomach acid production during long-term treatment for people with pre-existing stomach ulcers or for people having a history of developing stomach ulcers while using NSAIDs. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

How Naprosyn ES 500mg DR Tablet Works

Naprosyn ES 500mg DR Tablet combines Naproxen (painkiller) and esomeprazole (antacid). Naproxen is an anti-inflammatory drug that works by blocking the action of the body's cyclo-oxygenase (COX) enzyme to produce certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site, decreasing joint stiffness. Naproxen has been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. Hence, combined with esomeprazole (proton pump inhibitors), it reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Naprosyn ES 500mg DR Tablet

  • Confusion
  • Headaches
  • Ringing in the ears
  • Changes in vision
  • Tiredness and feeling sleepy
  • Dizziness
  • Rashes

What if I have taken an overdose of Naprosyn ES 500mg DR Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include drowsiness, severe weakness, vomiting, or stomach pain. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Naprosyn ES 500mg DR Tablet if you are allergic to Naprosyn ES 500mg DR Tablet . Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin), such as naproxen, may increase the risk of heart attack, stroke, and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older, are alcoholics, or have multiple diseases. Elderly patients are at greater risk for gastrointestinal bleeding problems, so the doctor can limit their dose. It should not be used by a patient who has undergone recent heart bypass surgery or going to have it. Naprosyn ES 500mg DR Tablet is not recommended for pregnant women, especially in the third trimester, as it may cause harm to the baby. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking Naprosyn ES 500mg DR Tablet . Naprosyn ES 500mg DR Tablet should not be given to children unless prescribed by a doctor. Do not take any other NSAIDs for pain relief along with Naprosyn ES 500mg DR Tablet unless prescribed. Prolonged proton pump inhibitors like esomeprazole may cause brittle bones, so your doctor may recommend taking Vitamin D and calcium while using Naprosyn ES 500mg DR Tablet . Do not consume alcohol with Naprosyn ES 500mg DR Tablet as it may increase the risk of stomach bleeding or ulcer.

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
NaproxenCidofovir
Critical

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Naprosyn ES 500mg DR Tablet 10's may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Naprosyn ES 500mg DR Tablet 10's with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
NaproxenCidofovir
Critical
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Taking cidofovir with Naprosyn ES 500mg DR Tablet 10's may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Naprosyn ES 500mg DR Tablet 10's with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
NaproxenKetorolac
Critical
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Coadministration of Ketorolac with Naprosyn ES 500mg DR Tablet 10's can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Naprosyn ES 500mg DR Tablet 10's together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
NaproxenMeloxicam
Critical
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Co-administration of Naprosyn ES 500mg DR Tablet 10's with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Naprosyn ES 500mg DR Tablet 10's is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
EsomeprazoleErlotinib
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Coadministration of erlotinib and Naprosyn ES 500mg DR Tablet 10's can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Naprosyn ES 500mg DR Tablet 10's together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
EsomeprazoleAtazanavir
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Naprosyn ES 500mg DR Tablet 10's reduces the absorption of atazanavir, resulting in reduced efficacy of atazanavir.

How to manage the interaction:
Although there is a possible interaction between Naprosyn ES 500mg DR Tablet 10's and atazanavir, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
EsomeprazolePazopanib
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Naprosyn ES 500mg DR Tablet 10's decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Naprosyn ES 500mg DR Tablet 10's and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
EsomeprazoleMethotrexate
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Co-administration of methotrexate and Naprosyn ES 500mg DR Tablet 10's can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Naprosyn ES 500mg DR Tablet 10's with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
EsomeprazoleClopidogrel
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Coadministration of Clopidogrel with Naprosyn ES 500mg DR Tablet 10's may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Naprosyn ES 500mg DR Tablet 10's together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleDasatinib
Severe
How does the drug interact with Naprosyn ES 500mg DR Tablet 10's:
Using Dasatinib together with Naprosyn ES 500mg DR Tablet 10's may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Naprosyn ES 500mg DR Tablet 10's together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Foods containing flavonoids, such as soy, berries, broccoli, grapes and green tea, help reduce inflammation.
  • Include high-fibre-containing foods, berries, cherries, leafy green veggies and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut and kimchi contain probiotics that help prevent excess stomach acid production.
  • Avoid acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

NON-STEROIDAL DRUG

Naprosyn ES 500mg DR Tablet Substitute

Substitutes safety advice
  • Esonap Tablet 10's

    13.50per tablet
  • Mapraxen Tablet 10's

    17.91per tablet
  • Proxzol Tablet 10's

    by AYUR

    22.32per tablet
  • Espra XN 500 Tablet 10's

    9.89per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Naprosyn ES 500mg DR Tablet as it may increase the risk of stomach bleeding and ulcer.

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Pregnancy

Caution

There is limited data on how Naprosyn ES 500mg DR Tablet affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Naprosyn ES 500mg DR Tablet .

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Breast Feeding

Caution

Naprosyn ES 500mg DR Tablet passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Naprosyn ES 500mg DR Tablet . Your doctor will weigh the benefits and any potential risks before prescribing Naprosyn ES 500mg DR Tablet to you.

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Driving

Caution

Naprosyn ES 500mg DR Tablet may cause dizziness, tiredness, drowsiness or vision problems in some people. So, drive only if you are alert after taking Naprosyn ES 500mg DR Tablet .

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Liver

Caution

Naprosyn ES 500mg DR Tablet is to be used with caution in people having liver diseases. Dose adjustments may be necessary. So, you should use it only with your doctor's prescription.

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Kidney

Caution

Naprosyn ES 500mg DR Tablet is not recommended for use in patients with moderate to severe and severe renal impairment. The dose may be adjusted by your doctor as required. So, it should be used only when prescribed by your doctor.

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Children

Caution

Naprosyn ES 500mg DR Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

FAQs

Naprosyn ES 500mg DR Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers used to reduce and relieve pain.
Naprosyn ES 500mg DR Tablet contains Naproxen (NSAID or pain reliever) and esomeprazole (antacid). Naproxen works by blocking the release of certain chemical messengers (prostaglandins) that cause pain and inflammation (redness and swelling). Esomeprazole works by blocking the action of the enzyme known as the gastric proton pump that is responsible for the production of acid. This helps reduce the amount of acid produced, heals the ulcers and prevents the formation of new ulcers.
You are not recommended to take Naprosyn ES 500mg DR Tablet with clopidogrel as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor immediately if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache. If you are supposed to use these medicines together, you are advised to contact your doctor to adjust the dose appropriately to use safely.
Yes, Naprosyn ES 500mg DR Tablet can alter specific medical tests like neuroendocrine tumors (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). So before undergoing such diagnostics test, contact your doctor.
Naproxen in Naprosyn ES 500mg DR Tablet may increase the risk of heart problems such as heart attack and stroke especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Naprosyn ES 500mg DR Tablet . However, it is recommended to take Naprosyn ES 500mg DR Tablet in the dose and for the duration as prescribed by your doctor. It should be not used by the patient who had recent heart bypass surgery (coronary artery bypass graft - CABG).
Naprosyn ES 500mg DR Tablet does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness. Arthritis is a chronic condition of joints with pain and inflammation.
Naprosyn ES 500mg DR Tablet is a pregnancy Category C medicine so, it is advisable to tell your doctor before its intake. It may inhibit ovulation (release of an egg from the ovary) and decrease the levels of progesterone leading to infertility in women. However, this effect is temporary and ovulation returns to normal mostly after one month of stopping Naprosyn ES 500mg DR Tablet . However, if you are planning for pregnancy or have difficulties becoming pregnant, please inform your doctor before taking Naprosyn ES 500mg DR Tablet .

Country of origin

India

Manufacturer/Marketer address

463, 4 Th Floor, Rpg House, Dr. Annie Besant Road, Worli, Mumbai €“ 400 030. Maharashtra, India
Other Info - NAP0092

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