Nalsign 50mg Tablet belongs to the class of medications called 'opioid-antagonist' used to treat alcohol dependence (chronic alcoholism) and opioid dependence. Alcohol dependence is a chronic medical condition that typically includes a current or past history of excessive drinking, a strong craving for alcohol, continued use despite repeated problems with drinking, and an inability to control alcohol consumption. Opioid dependence is a condition when someone becomes physically dependent on a substance; their body relies on it to avoid withdrawal.

Nalsign 50mg Tablet contains 'naltrexone'. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. Still, it is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

Nalsign 50mg Tablet should be taken as prescribed by your doctor. Some cases Nalsign 50mg Tablet may cause certain side effects such as nausea, vomiting, injection site reactions (including induration, pruritus, nodules and swelling), muscle cramps, dizziness or syncope, drowsiness or sedation, anorexia (eating disorder), decreased appetite or other appetite disorders, hepatic enzyme abnormalities, cold, insomnia, and toothache. Everyone need not experience the above side effects. If Nalsign 50mg Tablet causes any serious discomfort, speak with a doctor.

Before taking the Nalsign 50mg Tablet, let your doctor know about all your medical conditions (especially hepatitis or liver failure), allergic reactions, and all medications you are using (especially opioid analgesics). And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Nalsign 50mg Tablet may cause dizziness and sedation; therefore, avoid driving vehicles or operating machinery until you return to normal. Nalsign 50mg Tablet usage is contraindicated in patients with current physiologic opioid dependence, patients in acute opioid withdrawal, or any individual who has failed the naloxone challenge test or has a positive urine screen for opioids. If you notice mood changes while taking Nalsign 50mg Tablet, please consult a doctor immediately.

Nalsign 50mg Tablet contains naltrexone. It belongs to the class of medications called 'opioid-antagonist' used to treat alcohol dependence (chronic alcoholism) and opioid dependence. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. Still, it is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

• Nausea
• Vomiting
• Injection site reactions (induration, pruritus, nodules and swelling)
• Muscle cramps
• Dizziness or syncope
• Somnolence or sedation
• Anorexia (eating disorder)
• Decreased appetite or other appetite disorders
• Hepatic enzyme abnormalities
• Cold
• Insomnia (Sleeping disorder)
• Toothache

Before your doctor prescribes the Nalsign 50mg Tablet, inform them of all your medical conditions (particularly hepatitis or liver failure), allergic reactions (with food and medications), and medications you are taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding. Nalsign 50mg Tablet usage is contraindicated in patients with current physiologic opioid dependence, patients in acute opioid withdrawal, or any individual who has failed the naloxone challenge test or has a positive urine screen for opioids. Nalsign 50mg Tablet may cause dizziness and sedation; therefore, avoid driving vehicles or operating machinery until you return to normal. Do not use other medications without the doctor's notice, especially opioid-containing ones.

Drug-Drug interactions: Nalsign 50mg Tablet may interact with opioid- medications (e.g. codeine, hydrocodone), anti-rheumatic medications (e.g. leflunomide), and sedative medications (e.g. droperidol).

Drug-Food interactions: Consumption of alcohol should be prohibited.

Drug-Disease interactions: Nalsign 50mg Tablet may interact with various disease conditions, including kidney disease & liver disease, galactose intolerance, depression and suicidal tendencies.

• CODEINE
• HYDROCODONE
• LEFLUNOMIDE
• DROPERIDOL

• A patient is advised to have a diet that increases serotonin levels which makes a person feel good & involves eating foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread. Eating such foods in combination with protein in meals will benefit.

• Deficiencies in B-complex vitamins such as thiamine, folate or folic acid, and B12 are common with alcoholism, and inadequate stores of other B vitamins and vitamin C frequently occur. A patient should consume supplements and vitamins as per their doctor's recommendation.

• Malnutrition is common during alcohol consumption and is revealed slowly and gradually. The patient becomes very tired and develops a weaker immune system, which means the patient is more susceptible to infections. These problems need to be identified and treated during the recovery process—ideally by a team of healthcare professionals.

• The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, mixing juice or lemonade with sparkling water etc.

• Get physical activity and enough rest.

• Reduce caffeine and stop smoking, if possible.

• It is recommended to monitor liver function tests regularly.

• Patients should be opioid-free for at least 7-10 days before initiating the treatment.

• Strictly warn patients against the use of opioids while on Nalsign 50mg Tablet.

• Monitor for injection-site reactions.

Alcohol dependence: Alcohol dependence is a chronic medical condition that typically includes a current or past history of excessive drinking, a strong craving for alcohol, continued use despite repeated problems with drinking, and an inability to control alcohol consumption. Symptoms include blackout, dizziness, shakiness, craving, sweating, aggression, anxiety, nausea or vomiting, loneliness, delirium or fear, problems with coordination, slurred speech, or tremor.

Opioid-dependence: Opioid dependence is a condition when someone becomes physically dependent on a substance; their body relies on it to avoid withdrawal. In this case, instead of making enough of its own opioids, the body has begun to rely on outside opioids to maintain normal function. Symptoms include craving or sweating, euphoria or general discontent, physical substance dependence, chronic constipation, small pupils, nausea, reduced sex drive, sensitivity to pain, shallow breathing, or slurred speech.