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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nalsign 50mg Tablet is used to treat alcohol and opioid dependence. It contains Naltrexone which works by blocking the effect of opioid receptors and decreasing craving/urge to use alcohol or opioids. In some cases, this medicine may cause side effects such as nausea, vomiting, injection site reactions, muscle cramps, dizziness, drowsiness, and appetite changes. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

NALTREXONE-50MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Nalsign 50mg Tablet

Nalsign 50mg Tablet belongs to the class of medications called 'opioid-antagonist' used to treat alcohol dependence (chronic alcoholism) and opioid dependence. Alcohol dependence is a chronic medical condition that typically includes a current or past history of excessive drinking, a strong craving for alcohol, continued use despite repeated problems with drinking, and an inability to control alcohol consumption. Opioid dependence is a condition when someone becomes physically dependent on a substance; their body relies on it to avoid withdrawal.

Nalsign 50mg Tablet contains 'naltrexone'. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. Still, it is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

Nalsign 50mg Tablet should be taken as prescribed by your doctor. Some cases Nalsign 50mg Tablet may cause certain side effects such as nausea, vomiting, injection site reactions (including induration, pruritus, nodules and swelling), muscle cramps, dizziness or syncope, drowsiness or sedation, anorexia (eating disorder), decreased appetite or other appetite disorders, hepatic enzyme abnormalities, cold, insomnia, and toothache. Everyone need not experience the above side effects. If Nalsign 50mg Tablet causes any serious discomfort, speak with a doctor.

Before taking the Nalsign 50mg Tablet, let your doctor know about all your medical conditions (especially hepatitis or liver failure), allergic reactions, and all medications you are using (especially opioid analgesics). And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Nalsign 50mg Tablet may cause dizziness and sedation; therefore, avoid driving vehicles or operating machinery until you return to normal. Nalsign 50mg Tablet usage is contraindicated in patients with current physiologic opioid dependence, patients in acute opioid withdrawal, or any individual who has failed the naloxone challenge test or has a positive urine screen for opioids. If you notice mood changes while taking Nalsign 50mg Tablet, please consult a doctor immediately.

Uses of Nalsign 50mg Tablet

Treatment of Alcohol dependence and opioid dependence

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Nalsign 50mg Tablet contains naltrexone. It belongs to the class of medications called 'opioid-antagonist' used to treat alcohol dependence (chronic alcoholism) and opioid dependence. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. Still, it is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

How Nalsign 50mg Tablet Works

Nalsign 50mg Tablet contains 'naltrexone'. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. Still, it is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nalsign 50mg Tablet

  • Nausea
  • Vomiting
  • Injection site reactions (induration, pruritus, nodules and swelling)
  • Muscle cramps
  • Dizziness or syncope
  • Somnolence or sedation
  • Anorexia (eating disorder)
  • Decreased appetite or other appetite disorders
  • Hepatic enzyme abnormalities
  • Cold
  • Insomnia (Sleeping disorder)
  • Toothache

What if I have taken an overdose of Nalsign 50mg Tablet

Take Nalsign 50mg Tablet only as prescribed by the doctor. Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Before your doctor prescribes the Nalsign 50mg Tablet, inform them of all your medical conditions (particularly hepatitis or liver failure), allergic reactions (with food and medications), and medications you are taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding. Nalsign 50mg Tablet usage is contraindicated in patients with current physiologic opioid dependence, patients in acute opioid withdrawal, or any individual who has failed the naloxone challenge test or has a positive urine screen for opioids. Nalsign 50mg Tablet may cause dizziness and sedation; therefore, avoid driving vehicles or operating machinery until you return to normal. Do not use other medications without the doctor's notice, especially opioid-containing ones.

Drug-Drug Interactions

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NaltrexoneMethadone
Critical
NaltrexoneOpium
Critical

Drug-Drug Interactions

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NaltrexoneMethadone
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Methadone with Nalsign 50mg Tablet can increase the risk or severity of harmful side effects.

How to manage the interaction:
Taking Methadone with Nalsign 50mg Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneOpium
Critical
How does the drug interact with Nalsign 50mg Tablet:
Combining Nalsign 50mg Tablet with Opium can block the effects of opium, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Nalsign 50mg Tablet with Opium is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NaltrexonePethidine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Pethidine with Nalsign 50mg Tablet can block the effects of Pethidine and make the medication less effective.

How to manage the interaction:
Taking Pethidine with Nalsign 50mg Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneTapentadol
Critical
How does the drug interact with Nalsign 50mg Tablet:
Using Tapentadol together with Nalsign 50mg Tablet can block the effects of tapentadol, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Tapentadol with Nalsign 50mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhoea call a doctor right away. Do not stop using any medications without a doctor’s advice.
NaltrexonePentazocine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Nalsign 50mg Tablet with Pentazocine can reduce the effects of pentazocine and make the medication less effective.

How to manage the interaction:
Taking Pentazocine with Nalsign 50mg Tablet is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience any symptoms like nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
NaltrexoneMorphine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Using Morphine with Nalsign 50mg Tablet can block morphine's effects, which reduces its ability to effectively treat illness.

How to manage the interaction:
Taking Morphine with Nalsign 50mg Tablet together is generally avoided as it can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneDezocine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Coadministration of Nalsign 50mg Tablet with Dezocine can block the effects of Dezocine and make the medication less effective.

How to manage the interaction:
Taking Nalsign 50mg Tablet with Dezocine is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneNaloxegol
Severe
How does the drug interact with Nalsign 50mg Tablet:
Coadministration of Nalsign 50mg Tablet and Naloxegol can increase the effects of Naloxegol. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Nalsign 50mg Tablet and Naloxegol together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
NaltrexoneLeflunomide
Severe
How does the drug interact with Nalsign 50mg Tablet:
Taking Leflunomide and Nalsign 50mg Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Leflunomide and Nalsign 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A patient is advised to have a diet that increases serotonin levels which makes a person feel good & involves eating foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread. Eating such foods in combination with protein in meals will benefit.

  • Deficiencies in B-complex vitamins such as thiamine, folate or folic acid, and B12 are common with alcoholism, and inadequate stores of other B vitamins and vitamin C frequently occur. A patient should consume supplements and vitamins as per their doctor's recommendation.

  • Malnutrition is common during alcohol consumption and is revealed slowly and gradually. The patient becomes very tired and develops a weaker immune system, which means the patient is more susceptible to infections. These problems need to be identified and treated during the recovery process—ideally by a team of healthcare professionals.

  • The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, mixing juice or lemonade with sparkling water etc.

  • Get physical activity and enough rest.

  • Reduce caffeine and stop smoking, if possible.

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Therapeutic Class

OPIOID ANTAGONISTS

Nalsign 50mg Tablet Substitute

Substitutes safety advice
  • Naltima 50 Tablet 10's

    91.44per tablet
  • Nodict Tablet 10's

    93.60per tablet
  • Addtrex 50 mg Tablet 10's

    by AYUR

    72.14per tablet
  • Naltox-50 Tablet 10's

    76.82per tablet
  • Naltrawave Tablet 10's

    by AYUR

    77.40per tablet
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Alcohol

Caution

Consumption of alcohol is not recommended during treatment with this medicine.

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Pregnancy

Consult your doctor

There are no adequate and well-controlled studies of naltrexone in pregnant women. Nalsign 50mg Tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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Breast Feeding

Consult your doctor

Caution should be exercised while using Nalsign 50mg Tablet in nursing mother. Inform your doctor if you are a nursing mother. A decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.

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Driving

Caution

Nalsign 50mg Tablet may cause side effects which could affect your ability to drive or operate machinery.

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Liver

Caution

Nalsign 50mg Tablet should be used with caution in patients with liver disease. So, inform your doctor if you are with liver impairment. Regular monitoring of liver function tests is advisable while you are taking this medicine.

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Kidney

Caution

Caution is recommended in administering Nalsign 50mg Tablet to patients with moderate to severe renal impairment. So, inform your doctor if you are with kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Nalsign 50mg Tablet.

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Children

Caution

Nalsign 50mg Tablet should not be used in children and adolescents under 18 since clinical data in this age group are unavailable.

FAQs

Nalsign 50mg Tablet is used to treat alcohol dependence (chronic alcoholism) and opioid dependence.
Nalsign 50mg Tablet works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids, but it is used along with counselling and social support to help patients who are dependent on alcohol abstain from drinking alcoholic drinks.
No, Nalsign 50mg Tablet should not be used with an opioid analgesic, as it may cause serious adverse effects of the drug. If you have any concerns, please discuss them with your doctor.
Before taking the Nalsign 50mg Tablet, inform your doctor about your medical conditions (particularly hepatitis or liver failure), allergic reactions, and medications you are already taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.
Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.
Using Nalsign 50mg Tablet in any individual who has failed the naloxone challenge test or has a positive urine screen for opioids is contradicted.
Nalsign 50mg Tablet may cause side effects such as nausea, vomiting, drowsiness or sedation, anorexia (eating disorder), decreased appetite, insomnia, and toothache. If the side effects persist or worsen, speak with a doctor.
Nalsign 50mg Tablet should be used with caution in patients with liver disease. So, inform your doctor if have liver impairment. Regular monitoring of liver function is advisable while you are taking this medicine.
Nalsign 50mg Tablet can be taken with pain relievers other than opioid medications if prescribed by the doctor. Please consult the doctor before taking painkillers/any other medications with Nalsign 50mg Tablet.
Nalsign 50mg Tablet cough and cold medicines, thereby, you may not benefit from these medicines. Consult a doctor before taking Nalsign 50mg Tablet with cold, cough or allergy medicines.
You are advised to take Nalsign 50mg Tablet only for the duration prescribed by the doctor. Please consult the doctor if you have any concerns regarding the duration of treatment.
Nalsign 50mg Tablet may not make you high. It might cause sedation, drowsiness, and dizziness. Therefore, avoid driving, operating machinery or doing things that require alertness.
Yes, Nalsign 50mg Tablet decreases cravings and urge to use opioids by blocking the action of opioid receptors.

Country of origin

India
Other Info - NA32806

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