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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:19 PM IST

Mitobulin Solution for Injection 2 ml is used to treat Breast Cancer and Liposarcoma (cancer that develops in your fatty tissue). It contains Eribulin, which works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. While on therapy with this medicine, both women and men should use birth control to avoid pregnancy. Discontinue nursing while on treatment, considering the importance of the drug to the mother.

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Prescription drug

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Prescription drug
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Synonym

ERIBULIN

Manufacturer/Marketer

Cipla Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Mitobulin Solution for Injection 2 ml

Mitobulin Solution for Injection 2 ml belongs to a group of medicines known as 'anti-cancer' used to treat various cancers, including breast and liposarcoma. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. Breast cancer is cancer that forms in the cells of the breasts. A liposarcoma is a rare cancer that develops in your fatty tissue.

Mitobulin Solution for Injection 2 ml contains Eribulin, which works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer.

Mitobulin Solution for Injection 2 ml should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions that occur while on therapy are neutropenia (lower-than-normal levels of neutrophils), anaemia (lack of blood), asthenia (weakness), fatigue(tiredness), alopecia (hair loss), peripheral neuropathy (Weakness, numbness, and pain from nerve damage), nausea, and constipation. Most of these side effects of Mitobulin Solution for Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Mitobulin Solution for Injection 2 ml for as long as your doctor has prescribed. Do not stop using the Mitobulin Solution for Injection 2 ml midway. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Mitobulin Solution for Injection 2 ml should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Mitobulin Solution for Injection 2 ml in patients with hepatic, renal, heart dysfunction and or Neutropenia (Lower-than-normal levels of neutrophils), so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Mitobulin Solution for Injection 2 ml

Treatment of Breast Cancer and Liposarcoma (cancer that develops in your fatty tissue)

Medicinal Benefits

Mitobulin Solution for Injection 2 ml contains Eribulin, which belongs to a group of medicines known as 'anti-cancer' used to treat various types of cancers, including breast and liposarcoma. It works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer.

Directions for Use

Mitobulin Solution for Injection 2 ml should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mitobulin Solution for Injection 2 ml

  • Feeling sick (nausea)
  • Being sick
  • Feeling tired or weak (fatigue)
  • Loss of appetite
  • Weight loss
  • Headaches
  • Diarrhoea
  • Constipation
  • Pain in different parts of your body
  • Neutropenia (lower-than-normal levels of neutrophils)
  • Anemia (lack of blood)
  • Asthenia (weakness)
  • Alopecia (hair loss)
  • Peripheral neuropathy (weakness, numbness, and pain from nerve damage)

Drug Warnings

Before taking the Mitobulin Solution for Injection 2 ml, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Before taking Mitobulin Solution for Injection 2 ml, inform your doctor about your medical history and other medications you are currently taking in order to rule out any potential negative effects. Mitobulin Solution for Injection 2 ml may cause permanent fertility problems in men if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with Mitobulin Solution for Injection 2 ml. Avoid the consumption of alcoholic beverages and grapefruit juices.

Drug Interactions

Drug-Drug Interactions: Mitobulin Solution for Injection 2 ml interacts with medicines used for irregular heartbeat (e.g. amiodarone), immunomodulatory medication (e.g. baricitinib, fingolimod), vaccinations (e.g. BCG Vaccine, mumps virus vaccine, rotavirus vaccine), antidepression medication (e.g. citalopram), antipsychotic medications (e.g. Clozapine).

Drug-Food Interactions: Do not drink grapefruit juice or alcoholic beverages while you are being treated with Mitobulin Solution for Injection 2 ml. It can affect the way the medicine works.

Drug-Disease Interactions: Mitobulin Solution for Injection 2 ml may potentially interact with various disease conditions, including infections (bacterial/fungal/protozoal/viral), severe hepatic and renal impairment and congenital long QT syndrome.

Drug-Drug Interactions Checker List

  • AMIODARONE
  • BARICITINIB
  • FINGOLIMOD
  • BCG VACCINE
  • MUMPS VIRUS VACCINE
  • ROTAVIRUS VACCINE
  • CITALOPRAM
  • CLOZAPINE

Habit Forming

No

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Mitobulin Solution for Injection 2 ml.
  • Mitobulin Solution for Injection 2 ml should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Mitobulin Solution for Injection 2 ml.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Mitobulin Solution for Injection 2 ml treatment and, when appropriate, until recovery is achieved.
  • Do not donate sperm during treatment with Mitobulin Solution for Injection 2 ml and for three months after your last dose.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Breast cancer: It is a type of cancer that develops in breast cells stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other body parts. Symptoms of breast cancer include a lump in the breast or tissue thickening, which feels different than the normal surrounding tissues, breast pain, redness, swelling, and nipple discharge other than breast milk.

Liposarcoma: Liposarcoma is a rare tumour derived from fat tissue that occurs in the “soft tissues” of the body (soft tissue sarcoma). It is classified as a cancer (malignant) because of its potential to recur locally and spread to other areas of the body. The severity of the disease depends on the subtype of the liposarcoma and the presenting stage of the primary tumour. It can arise in various locations throughout the body, although it is most frequently found in the extremities, particularly in the thigh.

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Mitobulin Solution for Injection 2 ml.

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Pregnancy

Unsafe

Mitobulin Solution for Injection 2 ml should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

Mitobulin Solution for Injection 2 ml may cause side effects such as tiredness and dizziness. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

A lower starting dose is recommended for patients with mild (Child-Pugh A) and moderate (ChildPugh B) liver impairment. There is no information available on patients with severe liver impairment.

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Kidney

Caution

A lower starting dose is recommended for patients with moderate (CrCl 30-50 mL/min) kidney impairment. There is no information available on patients with severe kidney impairment.

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Children

Unsafe

Do not use this medicine for children between 0 to 18 years old.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - MIT0134

Author Details

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FAQs

Mitobulin Solution for Injection 2 ml is used to treat Renal Cell Carcinoma.
Mitobulin Solution for Injection 2 ml contains Eribulin, an anti-cancer medication that is used to treat several types of cancers, such as breast cancer and liposarcoma. It works by preventing the cancer cells from dividing into two new cells. As a result, it prevents cancer from spreading.
It is recommended not to be used in the population who are allergic to Eribulin or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, Mitobulin Solution for Injection 2 ml can cause low neutrophils levels, a type of white blood cells that help fight infections. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
Inform your doctor before receiving the Mitobulin Solution for Injection 2 ml if you suffer from QT Prolongation. Your doctor will monitor for prolonged QT intervals in patients with congestive heart failure, bradyarrhythmias, and electrolyte abnormalities. It is recommended not to be used in patients with congenital long QT syndrome.
Mitobulin Solution for Injection 2 ml may cause permanent fertility problems in men if they take it. Please discuss this with their doctor before starting treatment.
Mitobulin Solution for Injection 2 ml may cause hair loss as a common side effect. It is typically temporary and reversible once treatment is completed. However, the extent and duration of hair regrowth can vary from person to person. It is important to discuss any concerns with the doctor, as they can provide guidance based on your specific situation.
The duration of treatment with Mitobulin Solution for Injection 2 ml can be determined by the doctor based on your medical condition being treated. Always follow the doctor’s instructions regarding the duration of treatment and ensure regular follow-ups to treat the condition effectively.
Mitobulin Solution for Injection 2 ml be administered intravenously (IV) for 2 to 5 minutes by the doctor or nurse. Do not self-administer.
It is recommended to wait at least 3 months after completing treatment with Mitobulin Solution for Injection 2 ml before planning a pregnancy. This is because the medication may affect fertility and it may affect foetal development. Always consult the doctor for personalised advice and to ensure it is safe for you to conceive.
It is important to wear protective gloves to avoid direct contact while handling Mitobulin Solution for Injection 2 ml. The used needles and syringes should be disposed of in a proper medical waste container to prevent needle-stick injuries. You should avoid contact with the eyes or skin, if accidental exposure occurs, rinse it off thoroughly with plenty of water and seek medical attention if necessary. Always consult the doctor for specific handling instructions.
The side effects of Mitobulin Solution for Injection 2 ml include nausea, constipation, alopecia (hair loss), neutropenia (lower-than-normal levels of neutrophils), anaemia (lack of blood), asthenia (weakness), fatigue (tiredness), and peripheral neuropathy (Weakness, numbness, and pain from nerve damage). Consult the doctor if any of these side effects persist or worsen. The serious side effects of Mitobulin Solution for Injection 2 ml include cough, sore throat, fever (temperature greater than 100.5), chills, burning or pain when urinating, or other signs of infection numbness, burning, or tingling in the arms, legs, hands, or feet pale skin shortness of breath irregular heartbeat. Consult the doctor immediately if you experience any of these symptoms.
Mitobulin Solution for Injection 2 ml should be diluted with 0.9% sodium chloride injection or dextrose 5% injection before administration, as recommended by the manufacturer. The dilution helps to ensure the correct concentration and allows for the safe administration of the medication. Always follow the specific instructions provided by the doctor or the manufacturer's guidelines when preparing and administering the injection.

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