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  3. Mirel Injection 1's

Mirel Injection 1's, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mirel Injection is used in the treatment of ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. It contains Reteplase, which works by dissolving the blood clot that is blocking the heart's blood vessels. It may also treat a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart). Common side effects of Mirel Injection are bleeding, bruising at the injection site, nausea or vomiting.

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Synonym :

RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR

Composition :

RETEPLASE-18MG

Manufacturer/Marketer :

Reliance Formulation Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mirel Injection

Mirel Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.

Mirel Injection contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.

In some cases, Mirel Injection may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of Mirel Injection in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Mirel Injection

Treatment of ST-elevation myocardial infarction (STEMI)

Directions for Use

Mirel Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Mirel Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. Mirel Injection contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).

How Mirel Injection Works

Mirel Injection contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mirel Injection
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Regularly exercise and have a balanced diet to maintain a healthy weight.
  • Eat fruits and vegetables to maintain a healthy weight.
  • Include vitamin K-rich foods in your diet for stable anticoagulation control.
  • Limit red and processed meats.
  • Avoid smoking and consumption of alcohol to improve your condition.

What if I have taken an overdose of Mirel Injection

Since Mirel Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Mirel Injection should not be used if you are allergic to any of the components in Mirel Injection, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. Mirel Injection may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of Mirel Injection in children have not been established.

Drug-Drug Interactions

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ReteplaseFondaparinux
Severe
ReteplaseIbrutinib
Severe

Drug-Drug Interactions

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ReteplaseFondaparinux
Severe
How does the drug interact with Mirel Injection:
Taking Mirel Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between fondaparinux and Mirel Injection, you can take these medicines together if prescribed by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
ReteplaseIbrutinib
Severe
How does the drug interact with Mirel Injection:
Co-administration of Ibrutinib with Mirel Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Mirel Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
ReteplasePrasugrel
Severe
How does the drug interact with Mirel Injection:
Taking Prasugrel with Mirel Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Prasugrel with Mirel Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ReteplaseApixaban
Severe
How does the drug interact with Mirel Injection:
Coadministration of Mirel Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Mirel Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ReteplaseEnoxaparin
Severe
How does the drug interact with Mirel Injection:
Combining Mirel Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Although there is a possible interaction between Enoxaparin and Mirel Injection, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like bleeding, bruising, dizziness, or severe headache, it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
ReteplaseCangrelor
Severe
How does the drug interact with Mirel Injection:
Co-administration of Cangrelor with Mirel Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Cangrelor and Mirel Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
ReteplaseDabigatran etexilate
Severe
How does the drug interact with Mirel Injection:
Taking Dabigatran etexilate with Mirel Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Mirel Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include vegetables, fruits and whole grains in your diet.
  • Stop smoking.
  • Be physically active every day.
  • Aim for a healthy weight.
  • Limit the consumption of alcohol.
  • Manage stress with meditation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Mirel Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

Limited information is available. Please consult your doctor.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering Mirel Injection to a nursing mother.

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Driving

Consult your doctor

Limited information is available. Please consult your doctor.

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Liver

Caution

The potential risks with the therapy of Mirel Injection may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Kidney

Caution

The potential risks of Mirel Injection therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Children

Caution

The efficacy and safety of Mirel Injection in children have not been established.

Have a query?

FAQs

Mirel Injection is used to treat ST-elevation myocardial infarction (STEMI).

Mirel Injection works by dissolving the blood clot that is blocking the heart's blood vessels.

Mirel Injection may increase the risk of bleeding. The sites of bleeding could be internal or external. Talk to your doctor if you have any concerns.

Heparin and Mirel Injection are incompatible. Mirel Injection should not be administered through an intravenous line containing heparin. Please consult your doctor if you have any concerns.

Mirel Injection will be administered by a healthcare professional in a clinical setting. Do not attempt to administer it yourself. A trained healthcare professional will ensure safe and proper administration.

Yes, Mirel Injection is safe when used under the doctor’s supervision. It is used in the treatment of ST-elevation myocardial infarction (STEMI). However, it may cause some side effects like bleeding, bruising at the injection site, nausea, or vomiting in some cases. You are advised to talk to your doctor if any of the side effects persist or worsen.

Mirel Injection may interact with anti-coagulants like heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, and vitamin K antagonists. So, it’s best to consult your doctor before taking anti-coagulants or any other medications along with Mirel Injection.

Mirel Injection helps prevent blood clots from forming in your legs, lungs, heart, and brain. You may not feel any immediate effects after taking the medicine, but that doesn't mean it's not working. Continue taking the medicine exactly as prescribed by your doctor, even if you don't notice any difference.

The common side effects of Mirel Injection may include bleeding, bruising at the injection site, nausea, or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Dhirubhai Ambani Life Sciences Centre, R-282, Ttc Area Of Midc, Thane-Belapur Road, Rabale, Navi Mumbai 400 701.
Other Info - MIR0056

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:44 PM IST

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Reference

  1. https://resources.chiesiusa.com/Retavase/RETAVASE_PI.pdf
  2. https://ciplamed-library.com/content/retefast-intravenous-bolus-injection
  3. https://www.nps.org.au/assets/medicines/45e6f404-ef25-4095-b6ed-a53300ff2519.pdf
  4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e7b63b16-d911-478b-a445-b690a1360b48
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