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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mirakem S 50 Tab is used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination). It works by reducing the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. Additionally, it relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination.
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Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Mirakem S 50 Tab

Mirakem S 50 Tab is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination). Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control.
 
Mirakem S 50 Tab contains Solifenacin (anti-cholinergic) and Mirabegron (beta-3 adrenergic agonist). Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Mirakem S 50 Tab helps in treating overactive bladder.
 
You are advised to take Mirakem S 50 Tab for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side-effects such as dry mouth, constipation, headache, high blood pressure, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Mirakem S 50 Tab is not recommended for children as safety and efficacy have not been established. Mirakem S 50 Tab may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption along with Mirakem S 50 Tab as it could lead to increased dizziness. Inform your doctor about your health condition and medications before taking Mirakem S 50 Tab to rule out any side effects/interactions.

Uses of Mirakem S 50 Tab

Treatment of Overactive bladder syndrome

Directions for Use

Swallow Mirakem S 50 Tab as a whole with water; do not chew or break it.

Medicinal Benefits

Mirakem S 50 Tab is a combination of two drugs, namely: Solifenacin and Mirabegron. Mirakem S 50 Tab is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, dysuria (painful or difficult urination). Solifenacin is an anti-cholinergic that reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron is a beta-3 adrenergic agonist which relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Mirakem S 50 Tab helps in treating an overactive bladder.

How Mirakem S 50 Tab Works

Mirakem S 50 Tab contains Solifenacin (anti-cholinergic) and Mirabegron (beta-3 adrenergic agonist). Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Mirakem S 50 Tab helps in treating overactive bladder.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mirakem S 50 Tab

  • Constipation
  • Headache 
  • Dry mouth
  • Blurred vision
  • Vomiting
  • High blood pressure
  • Urinary tract infection

What if I have taken an overdose of Mirakem S 50 Tab

Take Mirakem S 50 Tab only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Mirakem S 50 Tab if you are allergic to any of its contents. Inform your doctor if you have glaucoma, myasthenia gravis, ulcerative colitis, urinary retention, high blood pressure, angioedema, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Mirakem S 50 Tab is not recommended for children. Mirakem S 50 Tab may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption with Mirakem S 50 Tab as it could lead to increased dizziness. 

Drug-Drug Interactions

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MirabegronEliglustat
Critical
SolifenacinPotassium chloride
Critical

Drug-Drug Interactions

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MirabegronEliglustat
Critical
How does the drug interact with Mirakem S 50 Tablet 10's:
Coadministration of Eliglustat and Mirakem S 50 Tablet 10's can significantly increase the blood levels of eliglustat. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Mirakem S 50 Tablet 10's with Eliglustat is not recommended, it should be taken only when advised by a doctor. You should seek immediate medical help if you develop symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, irregular heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without a doctor's advice.
SolifenacinPotassium chloride
Critical
How does the drug interact with Mirakem S 50 Tablet 10's:
Taking Mirakem S 50 Tablet 10's and Potassium chloride together can increase the risk of stomach ulcers, bleeding, and stomach injury.

How to manage the interaction:
Taking Mirakem S 50 Tablet 10's with Potassium chloride is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
SolifenacinItraconazole
Critical
How does the drug interact with Mirakem S 50 Tablet 10's:
The blood levels and effects of Mirakem S 50 Tablet 10's may be greatly increased when combined with itraconazole.

How to manage the interaction:
Mirakem S 50 Tablet 10's and Itraconazole may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
SolifenacinMesoridazine
Critical
How does the drug interact with Mirakem S 50 Tablet 10's:
Using Mesoridazine together with Mirakem S 50 Tablet 10's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Mirakem S 50 Tablet 10's is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor.
MirabegronTamoxifen
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
Coadministration of Mirakem S 50 Tablet 10's and Tamoxifen may reduce the effects of tamoxifen.

How to manage the interaction:
Taking Mirakem S 50 Tablet 10's and Tamoxifen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience painful urination, constipation, dry mouth, headache, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronBrexpiprazole
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
A combined use of Mirakem S 50 Tablet 10's and Brexpiprazole may increase the level of Brexpiprazole in blood. This can increase the risk or severity of side effects.

How to manage the interaction:
There could be a possible interaction between Mirakem S 50 Tablet 10's and Brexpipraole, it can be taken together if your doctor has advised them. However, if you experience drowsiness, fatigue, seizure, chest pain or tightness, irregular heart rates, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramp, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronAripiprazole
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
Combining Aripiprazole with Mirakem S 50 Tablet 10's can increase the levels of Aripiprazole in the body. This can lead to increased risk or severity of side effects.

How to manage the interaction:
Although taking Mirakem S 50 Tablet 10's and Aripiprazole together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs like feeling sleepy, having seizures, unusual muscle movements, low blood pressure, feeling confused, muscle spasms, twitching in your jaw, shaking or jerking in your arms and legs, feeling nervous or restless, dizziness, lightheaded, or fainting contact the doctor right away. Do not stop using any medications without a doctor's advice.
MirabegronVenetoclax
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
Coadministration of Mirakem S 50 Tablet 10's and Venetoclax may significantly increase the blood levels and effects of Venetoclax. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possible interaction between Mirakem S 50 Tablet 10's and Venetoclax, but they can be taken together if your doctor has prescribed them. However, if you experience nausea, vomiting, diarrhea, fatigue, fever, chills, bleeding problems, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronThioridazine
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
Combine use of Mirakem S 50 Tablet 10's and thioridazine may raise the blood levels of thioridazine. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Mirakem S 50 Tablet 10's and thioridazine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience stomach pain, diarrhea, dehydration, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronPimozide
Severe
How does the drug interact with Mirakem S 50 Tablet 10's:
Combined use of Mirakem S 50 Tablet 10's and Pimozide may increase the level of pimozide in the blood. This can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Mirakem S 50 Tablet 10's and Pimozide may lead to an interaction but they can be taken together if your doctor has prescribed them. However, if you experience drowsiness, blurred vision, dry mouth, constipation, low blood pressure, tremors, trembling of hands, arms, legs, jaw and face, balance and Speech difficulty, or abnormal muscle movements consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pelvic floor exercises would be helpful in treating bladder spasms.

  • Avoid foods like sugars, carbonated beverages, tea, citrus fruits, tomatoes, spicy foods, chocolate and tea. 

  • Avoid drinking excess alcohol or caffeinated drinks, as they can worsen the symptoms.

  • Maintain a healthy weight, and exercise regularly.

  • Quit smoking.

  • Take 6-8glasses of liquids every day.

  • Avoid processed foods. Instead, choose whole, unprocessed foods.

  • Include fruits, vegetables, and fibre-rich food in your diet.

Habit Forming

No

Therapeutic Class

ANTICHOLINERGICS

Mirakem S 50 Tab Substitute

Substitutes safety advice
  • Mirago-S 50 Tablet 10's

    54.09per tablet
  • Mirbeg-S 50 Tablet 10's

    54.54per tablet
  • Megatas-S 50 Tablet 10's

    56.66per tablet
  • Lupin Mira-S 50 Tablet 10's

    59.85per tablet
  • Bladmir-S 50 Tablet 10's

    53.96per tablet
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Alcohol

Caution

You are recommended to avoid or limit alcohol consumption while taking Mirakem S 50 Tab as it may cause increased dizziness.

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Pregnancy

Caution

Limited information is available regarding the usage of Mirakem S 50 Tab during pregnancy. Consult your doctor before taking Mirakem S 50 Tab if you are pregnant.

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Breast Feeding

Caution

Limited information is available regarding the usage of Mirakem S 50 Tab during breastfeeding. Consult your doctor before taking Mirakem S 50 Tab if you are breastfeeding.

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Driving

Caution

Mirakem S 50 Tab may cause blurred vision and tiredness. Drive or operate machinery only if you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Mirakem S 50 Tab is not recommended for children as safety and effectiveness have not been established.

FAQs

Mirakem S 50 Tab is used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination).
Mirakem S 50 Tab contains Solifenacin and Mirabegron. Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Mirakem S 50 Tab helps in treating an overactive bladder.
There is some overlap between the symptoms of both OAB and BPH. OAB occurs due to uncontrolled urinary bladder muscle contractions. The main symptom of OAB is a sudden urge to urinate that's hard to control, which is stressful. On the other hand, BPH occurs due to an enlarged prostate gland, which puts pressure on the urinary bladder, thereby causing pain during urination.
Dry mouth could be a side effect of Mirakem S 50 Tab . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol; drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Mirakem S 50 Tab might cause hypertension. Therefore, consult your doctor before taking Mirakem S 50 Tab if you have high blood pressure.
Constipation could be a side-effect of Mirakem S 50 Tab . Eat fibre-rich food and drink plenty of fluids if you experience constipation. Talk to your doctor if you have severe constipation.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - MIR0229

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