Minirin Nasal Spray belongs to the class of 'antidiuretics', primarily used as replacement therapy in central cranial diabetes insipidus, a condition in which the body fails to control water balance, resulting in excessive urination. Minirin Nasal Spray is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma or surgery in the pituitary gland.

Minirin Nasal Spray contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, Minirin Nasal Spray is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration. 

Minirin Nasal Spray is for intranasal use only. Your doctor will decide the dosage depending on your medical condition. The common side effects of Minirin Nasal Spray include conjunctivitis/red eyes, weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing (sense of warmth) of the face. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting Minirin Nasal Spray , let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart problems/failure, swelling or scarring of the nasal lining, and illnesses that cause fluid/mineral imbalance. While using Minirin Nasal Spray , avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Pregnant and breastfeeding women should consult their doctor before using Minirin Nasal Spray . 

Minirin Nasal Spray is a hormone analogue that contains Desmopressin, a synthetic form of Vasopressin (an antidiuretic hormone that controls fluid balance). Minirin Nasal Spray mimics the natural hormone vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination. Minirin Nasal Spray is not indicated for the treatment of nephrogenic diabetes insipidus.

• Conjunctivitis/red eyes
• Weakness
• Headache
• Nose bleeds
• Nasal congestion/stuffy nose
• Rhinitis/runny nose
• Nausea
• Upset stomach
• Abdominal pain
• Flushing of the face 

Before starting Minirin Nasal Spray , let your doctor know if you have any history of allergic reactions to antidiuretic hormones, severe kidney disease, hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart failure, illnesses that cause fluid/mineral imbalance (cystic fibrosis), and fluid retention. Please consult your doctor before starting Minirin Nasal Spray if you are pregnant, planning to conceive or are a breastfeeding mother. Alcohol consumption may interfere with the working of Minirin Nasal Spray ; hence it is advised to limit or avoid its intake. Minirin Nasal Spray should be used in children only when prescribed by the doctor.

Drug-Drug Interaction: Minirin Nasal Spray may interact with anti-diarrhoeal medicines (loperamide), antidiabetics (chlorpropamide, glibenclamide), high cholesterol-lowering drugs (clofibrate), pain killers (naproxen, ibuprofen), fits medicines (carbamazepine), antipsychotics (chlorpromazine), water pills (furosemide), and antidepressants (lithium, fluoxetine, sertraline).

Drug-Food Interaction: Avoid alcohol since it may interfere with the working of Minirin Nasal Spray and increase urination. 

Drug-Disease Interaction: Tell your doctor before taking Minirin Nasal Spray if you have a medical history of kidney diseases, hyponatremia, excess fluid intake, high blood pressure, heart failure, fluid/mineral imbalance, and fluid retention. 

• LOPERAMIDE
• CHLORPROPAMIDE
• GLIBENCLAMIDE
• CLOFIBRATE
• NAPROXEN
• IBUPROFEN
• CARBAMAZEPINE
• CHLORPROMAZINE
• FUROSEMIDE
• LITHIUM
• FLUOXETINE
• SERTRALINE

• Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
• Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
• Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
• Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
• Optimal water intake is recommended to prevent dehydration due to excessive urination.

• Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
• If you are more frequently urinating than usual, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
• Your doctor may advise kidney functioning tests to monitor for renal impairment.

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. It is caused due to following: 

A) Central diabetes insipidus: It is caused when the pituitary gland cannot produce enough vasopressin (an antidiuretic hormone that maintains fluid balance). It is characterized by excessive thirst (polydipsia) and excessive urination (polyuria).

B) Nephrogenic diabetes insipidus: Though you make enough vasopressin, your kidneys may not respond to vasopressin that regulates fluid balance.