Migranil Tablet belongs to the class of medications called 'antimigraine agents' used to prevent migraine symptoms like intense throbbing in one area, headache, nausea and vomiting. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. 
 
Migranil Tablet contains Ergotamine (alkaloid), Caffeine (methylxanthine), Paracetamol (mild analgesic) and Belladonna (alkaloid). Ergotamine works by narrowing the blood vessels in the brain and affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Belladonna works by blocking the chemicals of the nervous system. Paracetamol blocks the release of prostaglandins that cause pain and fever. Together, Migranil Tablet helps treat signs and symptoms of migraine.
 
You are advised to take Migranil Tablet for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as stomach pain, dizziness, dry mouth and diarrhoea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Migranil Tablet contains paracetamol, do not take other medicines containing paracetamol along with Migranil Tablet unless prescribed. Do not take Migranil Tablet if you are pregnant or breastfeeding. Migranil Tablet may cause dizziness, so drive with caution. Migranil Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Migranil Tablet as it could lead to increased dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Migranil Tablet is a combination of four drugs, namely: Ergotamine, caffeine, belladonna and paracetamol. Migranil Tablet is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine which enhances the vasoconstrictive effect (narrowing of blood vessels). Belladonna works by blocking the chemicals of the nervous system. Paracetamol is an analgesic which blocks the release of prostaglandins that cause pain. Together, Migranil Tablet helps in treating migraine.

• Stomach pain
• Dizziness
• Dry mouth
• Diarrhoea
• Constipation
• Tachycardia (increased heart rate)
• Blurred vision

Do not take Migranil Tablet if you are allergic to any of its contents, if you have/had heart problems, blood circulation problems, or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Migranil Tablet contains paracetamol, do not take other medicines containing paracetamol along with Migranil Tablet unless prescribed. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver or kidney problems. Do not take Migranil Tablet if you are pregnant or breastfeeding. Migranil Tablet may cause dizziness, so drive only if you are alert. Migranil Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Migranil Tablet as it could lead to increased dizziness. Do not take any other medicines for pain relief along with Migranil Tablet unless prescribed. 

Drug-Drug Interactions: Migranil Tablet may interact with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole), anti-HIV medicines (indinavir, nelfinavir, ritonavir), a decongestant (oxymetazoline), pain killers (acetaminophen, butalbital, fentanyl), anti-depressant (fluoxetine), anti-anxiety (diazepam), antacid (ranitidine).

Drug-Food Interactions: Avoid the consumption of alcohol and caffeinated products. Do not consume grapefruit while taking Migranil Tablet .

Drug-Disease Interactions: Inform your doctor if you have high blood pressure, heart problems, bipolar disorder, psychotic disorders, seizure disorders, gastroesophageal reflux disease, liver or kidney problems.

• CLARITHROMYCIN
• ERYTHROMYCIN
• TROLEANDOMYCIN
• ITRACONAZOLE
• KETOCONAZOLE
• INDINAVIR
• NELFINAVIR
• RITONAVIR
• OXYMETAZOLINE
• ACETAMINOPHEN
• FENTANYL
• BUTALBITAL
• FLUOXETINE
• DIAZEPAM
• RANITIDINE

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
• Avoid bright lights, loud noise, and extreme temperatures.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Massage your scalp to ease the pain.
• Lie down in a quiet, dark room.
• Place a cold cloth over your forehead or neck.
• Avoid smoking, alcohol, and caffeinated drinks. 
• Learn what triggers your migraine and try avoiding them.
• Stay hydrated. Drink plenty of fluids.
• Learn relaxation skills as they help in reducing stress.

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability and neck stiffness. Symptoms of migraine include throbbing pain in one particular area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, sensitivity to sound and light.